DOI: 10.1083/jcb.120.2.313. Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis.

Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis.

10.1083/jcb.120.2.313

Crossref journal-article

Rockefeller University Press

The Journal of cell biology (291)

Abstract

Ran/TC4, first identified as a well-conserved gene distantly related to H-RAS, encodes a protein which has recently been shown in yeast and mammalian systems to interact with RCC1, a protein whose function is required for the normal coupling of the completion of DNA synthesis and the initiation of mitosis. Here, we present data indicating that the nuclear localization of Ran/TC4 requires the presence of RCC1. Transient expression of a Ran/TC4 protein with mutations expected to perturb GTP hydrolysis disrupts host cell DNA synthesis. These results suggest that Ran/TC4 and RCC1 are components of a GTPase switch that monitors the progress of DNA synthesis and couples the completion of DNA synthesis to the onset of mitosis.

Bibliography

Ren, M., Drivas, G., DâEustachio, P., & Rush, M. G. (1993). Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis. The Journal of Cell Biology, 120(2), 313â323.

Authors 4

M Ren (first)
G Drivas (additional)
P D'Eustachio (additional)
M G Rush (additional)

References 0 Referenced 145

None

Dates

Type	When
Created	21 years, 3 months ago (May 14, 2004, 8:22 p.m.)
Deposited	2 years, 1 month ago (July 22, 2023, 12:17 a.m.)
Indexed	1 month, 1 week ago (July 28, 2025, 2:31 a.m.)
Issued	32 years, 7 months ago (Jan. 15, 1993)
Published	32 years, 7 months ago (Jan. 15, 1993)
Published Online	32 years, 7 months ago (Jan. 15, 1993)
Published Print	32 years, 7 months ago (Jan. 15, 1993)

Funders 0

None

BibTeX

@article{Ren_1993, title={Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis.}, volume={120}, ISSN={1540-8140}, url={http://dx.doi.org/10.1083/jcb.120.2.313}, DOI={10.1083/jcb.120.2.313}, number={2}, journal={The Journal of cell biology}, publisher={Rockefeller University Press}, author={Ren, M and Drivas, G and D’Eustachio, P and Rush, M G}, year={1993}, month=jan, pages={313–323} }

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