DOI: 10.1083/jcb.111.6.2931. Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate.

Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate.

10.1083/jcb.111.6.2931

Crossref journal-article

Rockefeller University Press

The Journal of cell biology (291)

Abstract

The folate receptor is a glycosyl-phosphatidylinositol (GPI)-anchored membrane protein that mediates the delivery of 5-methyltetrahydrofolate to the cytoplasm of MA104 cells. Ordinarily the receptor is sequestered into numerous discrete clusters that are associated with an uncoated pit membrane specialization called a caveola. By using two different methodological approaches, we found that the maintenance of both receptor clusters and caveolae depends upon the presence of cholesterol in the membrane. These results suggest that cholesterol plays a critical role in maintaining the caveola membrane domain and modulates the interaction of GPI-anchored membrane proteins via their phospholipid anchors.

Bibliography

Rothberg, K. G., Ying, Y. S., Kamen, B. A., & Anderson, R. G. (1990). Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate. The Journal of Cell Biology, 111(6), 2931â2938.

Authors 4

K G Rothberg (first)
Y S Ying (additional)
B A Kamen (additional)
R G Anderson (additional)

References 0 Referenced 403

None

Dates

Type	When
Created	21 years, 3 months ago (May 14, 2004, 8:18 p.m.)
Deposited	2 years, 1 month ago (July 21, 2023, 9:16 p.m.)
Indexed	3 days, 5 hours ago (Aug. 20, 2025, 8:43 a.m.)
Issued	34 years, 8 months ago (Dec. 1, 1990)
Published	34 years, 8 months ago (Dec. 1, 1990)
Published Online	34 years, 8 months ago (Dec. 1, 1990)
Published Print	34 years, 8 months ago (Dec. 1, 1990)

Funders 0

None

BibTeX

@article{Rothberg_1990, title={Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate.}, volume={111}, ISSN={1540-8140}, url={http://dx.doi.org/10.1083/jcb.111.6.2931}, DOI={10.1083/jcb.111.6.2931}, number={6}, journal={The Journal of cell biology}, publisher={Rockefeller University Press}, author={Rothberg, K G and Ying, Y S and Kamen, B A and Anderson, R G}, year={1990}, month=dec, pages={2931–2938} }

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