DOI: 10.1083/jcb.111.4.1701. Regional and cellular codistribution of interleukin 1 beta and nerve growth factor mRNA in the adult rat brain: possible relationship to the regulation of nerve growth factor synthesis.

Regional and cellular codistribution of interleukin 1 beta and nerve growth factor mRNA in the adult rat brain: possible relationship to the regulation of nerve growth factor synthesis.

10.1083/jcb.111.4.1701

Crossref journal-article

Rockefeller University Press

The Journal of cell biology (291)

Abstract

We have found a regional distribution of IL 1 beta mRNA and IL 1 activity in the normal adult rat brain, which reveals at least partially a colocalization with nerve growth factor (NGF). The predominantly neuronal signal patterns were found over the granule cells of the dentate gyrus, the pyramidal cells of the hippocampus, the granule cells of the cerebellum, the granule and periglomerular cells of the olfactory bulb, and over dispersed cells of the ventromedial hypothalamus and of the frontal cortex. In these areas also the highest levels of IL 1 activity were observed. In the striatum and septum much lower levels of IL 1 beta mRNA and IL 1 activity (shown for the striatum), most likely synthesized by glial cells, could be determined. IL 1 beta-expressing cells were mainly found in brain regions that also synthesize NGF mRNA as shown by in situ hybridization. NGF mRNA could be demonstrated over pyramidal cells of the hippocampus, granule cells of the dentate gyrus, periglomerular cells of the olfactory bulb and over prefrontal cortex neurons. These data indicate that IL 1 beta, among other factors, might also play a regulatory role in the synthesis of NGF in the CNS, as has been demonstrated in the peripheral nervous system (Lindholm, D., R. Heumann, M. Meyer, and H. Thoenen. 1987. Nature (Lond.). 330:658-659).

Authors 6

C E Bandtlow (first)
M Meyer (additional)
D Lindholm (additional)
M Spranger (additional)
R Heumann (additional)
H Thoenen (additional)

References 0 Referenced 184

None

Dates

Type	When
Created	21 years, 3 months ago (May 14, 2004, 8:18 p.m.)
Deposited	2 years, 1 month ago (July 21, 2023, 9:12 p.m.)
Indexed	1 week, 3 days ago (Aug. 23, 2025, 1 a.m.)
Issued	34 years, 11 months ago (Oct. 1, 1990)
Published	34 years, 11 months ago (Oct. 1, 1990)
Published Online	34 years, 11 months ago (Oct. 1, 1990)
Published Print	34 years, 11 months ago (Oct. 1, 1990)

Funders 0

None

BibTeX

@article{Bandtlow_1990, title={Regional and cellular codistribution of interleukin 1 beta and nerve growth factor mRNA in the adult rat brain: possible relationship to the regulation of nerve growth factor synthesis.}, volume={111}, ISSN={1540-8140}, url={http://dx.doi.org/10.1083/jcb.111.4.1701}, DOI={10.1083/jcb.111.4.1701}, number={4}, journal={The Journal of cell biology}, publisher={Rockefeller University Press}, author={Bandtlow, C E and Meyer, M and Lindholm, D and Spranger, M and Heumann, R and Thoenen, H}, year={1990}, month=oct, pages={1701–1711} }

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