DOI: 10.1083/jcb.109.4.1633. Sequence similarity of the amino-terminal domain of Drosophila beta spectrin to alpha actinin and dystrophin.

10.1083/jcb.109.4.1633

Crossref journal-article

Rockefeller University Press

The Journal of cell biology (291)

Abstract

We used chicken alpha spectrin as a ligand probe to isolate Drosophila beta spectrin cDNA sequences from a lambda gt11 expression library. Analysis of 800 residues of deduced amino acid sequence at the amino-terminal end revealed a strikingly conserved domain of integral of 230 residues that shows a high degree of sequence similarity to the amino-terminal domains of alpha actinin and dystrophin. This conserved domain constitutes a new diagnostic criterion for spectrin-related proteins and allows the known properties of one of these proteins to predict functional properties of the others. The conservation of the amino-terminal domain, and other regions in spectrin, alpha actinin, and dystrophin, demonstrates that a common set of domains were linked in different combinations through evolution to generate the distinctive members of the spectrin superfamily.

Bibliography

Byers, T. J., Husain-Chishti, A., Dubreuil, R. R., Branton, D., & Goldstein, L. S. (1989). Sequence similarity of the amino-terminal domain of Drosophila beta spectrin to alpha actinin and dystrophin. The Journal of Cell Biology, 109(4), 1633â1641.

Authors 5

T J Byers (first)
A Husain-Chishti (additional)
R R Dubreuil (additional)
D Branton (additional)
L S Goldstein (additional)

References 0 Referenced 105

None

Dates

Type	When
Created	21 years, 3 months ago (May 14, 2004, 8:18 p.m.)
Deposited	2 years, 1 month ago (July 21, 2023, 8:48 p.m.)
Indexed	4 months, 2 weeks ago (April 10, 2025, 11:07 a.m.)
Issued	35 years, 10 months ago (Oct. 1, 1989)
Published	35 years, 10 months ago (Oct. 1, 1989)
Published Online	35 years, 10 months ago (Oct. 1, 1989)
Published Print	35 years, 10 months ago (Oct. 1, 1989)

Funders 0

None

BibTeX

@article{Byers_1989, title={Sequence similarity of the amino-terminal domain of Drosophila beta spectrin to alpha actinin and dystrophin.}, volume={109}, ISSN={1540-8140}, url={http://dx.doi.org/10.1083/jcb.109.4.1633}, DOI={10.1083/jcb.109.4.1633}, number={4}, journal={The Journal of cell biology}, publisher={Rockefeller University Press}, author={Byers, T J and Husain-Chishti, A and Dubreuil, R R and Branton, D and Goldstein, L S}, year={1989}, month=oct, pages={1633–1641} }

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