DOI: 10.1083/jcb.107.6.2075. Alphavirus RNA replicase is located on the cytoplasmic surface of endosomes and lysosomes.

Alphavirus RNA replicase is located on the cytoplasmic surface of endosomes and lysosomes.

10.1083/jcb.107.6.2075

Crossref journal-article

Rockefeller University Press

The Journal of cell biology (291)

Abstract

Using morphological and cell biological techniques, we have shown that the RNA replicase of Semliki Forest and Sindbis virus (two closely related alphaviruses) is located in complex ribonucleoprotein structures associated with the cytoplasmic surface of modified secondary lysosomes and endosomes. These nucleoprotein complexes often form a bridge between the membrane of the endocytic vacuole and the rough endoplasmic reticulum where the synthesis of the structural proteins of these viruses occurs. The results suggest that these cytopathic vacuoles constitute sites not only for viral RNA synthesis, but also for translation of structural proteins, and for the assembly of nucleocapsids.

Bibliography

Froshauer, S., Kartenbeck, J., & Helenius, A. (1988). Alphavirus RNA replicase is located on the cytoplasmic surface of endosomes and lysosomes. The Journal of Cell Biology, 107(6), 2075â2086.

Authors 3

S Froshauer (first)
J Kartenbeck (additional)
A Helenius (additional)

References 0 Referenced 327

None

Dates

Type	When
Created	21 years, 3 months ago (May 14, 2004, 8:18 p.m.)
Deposited	2 years, 1 month ago (July 21, 2023, 8:46 p.m.)
Indexed	3 months, 2 weeks ago (May 13, 2025, 7:32 p.m.)
Issued	36 years, 9 months ago (Dec. 1, 1988)
Published	36 years, 9 months ago (Dec. 1, 1988)
Published Online	36 years, 9 months ago (Dec. 1, 1988)
Published Print	36 years, 9 months ago (Dec. 1, 1988)

Funders 0

None

BibTeX

@article{Froshauer_1988, title={Alphavirus RNA replicase is located on the cytoplasmic surface of endosomes and lysosomes.}, volume={107}, ISSN={1540-8140}, url={http://dx.doi.org/10.1083/jcb.107.6.2075}, DOI={10.1083/jcb.107.6.2075}, number={6}, journal={The Journal of cell biology}, publisher={Rockefeller University Press}, author={Froshauer, S and Kartenbeck, J and Helenius, A}, year={1988}, month=dec, pages={2075–2086} }

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