DOI: 10.1074/jbc.m503202200. High Density of Octaarginine Stimulates Macropinocytosis Leading to Efficient Intracellular Trafficking for Gene Expression

High Density of Octaarginine Stimulates Macropinocytosis Leading to Efficient Intracellular Trafficking for Gene Expression

10.1074/jbc.m503202200

Crossref journal-article

Elsevier BV

Journal of Biological Chemistry (78)

Bibliography

Khalil, I. A., Kogure, K., Futaki, S., & Harashima, H. (2006). High Density of Octaarginine Stimulates Macropinocytosis Leading to Efficient Intracellular Trafficking for Gene Expression. Journal of Biological Chemistry, 281(6), 3544â3551.

Authors 4

Ikramy A. Khalil (first)
Kentaro Kogure (additional)
Shiroh Futaki (additional)
Hideyoshi Harashima (additional)

References 42 Referenced 342

10.1016/S0962-8924(00)01771-2 / Trends Cell Biol. by Schwarze (2000)
10.1016/S0165-6147(00)01447-4 / Trends Pharmacol Sci. by Lindgren (2000)
10.1023/B:PHAM.0000019289.61978.f5 / Pharm. Res. by Snyder (2004)
10.1073/pnas.151247498 / Proc. Natl. Acad. Sci. U. S. A. by Torchilin (2001)
10.1016/j.bbamem.2004.06.022 / Biochim. Biophys. Acta by Fretz (2004)
{'key': '10.1074/jbc.M503202200_bib6', 'first-page': '1785', 'volume': '61', 'author': 'Marty', 'year': '2004', 'journal-title': 'Cell Mol. Life Sci.'} / Cell Mol. Life Sci. by Marty (2004)
10.1073/pnas.0435906100 / Proc. Natl. Acad. Sci. U. S. A. by Torchilin (2003)
10.1074/jbc.272.25.16010 / J. Biol. Chem. by Vives (1997)
10.1074/jbc.271.30.18188 / J. Biol. Chem. by Derossi (1996)
10.1016/j.ejpb.2004.02.018 / Eur. J. Pharm. Biopharm. by Trehin (2004)
10.1074/jbc.M209548200 / J. Biol. Chem. by Richard (2003)
10.1016/S1525-0016(03)00135-7 / Mol. Ther. by Lundberg (2003)
10.1074/jbc.M303938200 / J. Biol. Chem. by Drin (2003)
10.1038/nm996 / Nat. Med. by Wadia (2004)
10.1016/j.jconrel.2004.10.018 / J. Control. Release by Kaplan (2005)
10.1016/j.ymthe.2004.08.010 / Mol. Ther. by Nakase (2004)
10.1074/jbc.M303045200 / J. Biol. Chem. by Fittipaldi (2003)
10.1016/S1525-0016(03)00122-9 / Mol. Ther. by Ferrari (2003)
10.1074/jbc.M007540200 / J. Biol. Chem. by Futaki (2001)
10.1074/jbc.M110017200 / J. Biol. Chem. by Suzuki (2002)
10.1016/j.addr.2004.12.001 / Adv. Drug Deliv. Rev. by Brooks (2005)
10.1038/sj.gt.3302128 / Gene Ther. by Khalil (2004)
10.1126/science.285.5433.1569 / Science by Schwarze (1999)
10.1074/jbc.M010625200 / J. Biol. Chem. by Eguchi (2001)
10.1021/bc015508l / Bioconjug. Chem. by Futaki (2001)
10.1016/j.jconrel.2004.04.024 / J. Control. Release by Kogure (2004)
10.1074/jbc.M401604200 / J. Biol. Chem. by Richard (2005)
10.1074/jbc.M301726200 / J. Biol. Chem. by Console (2003)
10.1016/S0003-9861(02)00725-7 / Arch. Biochem. Biophys. by Almofti (2003)
10.1016/0955-0674(95)80015-8 / Curr. Opin. Cell Biol. by Lamaze (1995)
10.1038/nature01451 / Nature by Conner (2003)
10.1016/S0962-8924(00)89101-1 / Trends Cell Biol. by Swanson (1995)
10.1083/jcb.200112067 / J. Cell Biol. by Meier (2002)
10.1038/nrm1017 / Nat. Rev. Mol. Cell Biol. by Parton (2003)
10.2174/138161280506230110111312 / Curr. Pharm. Des. by Singh (1999)
10.1074/jbc.M111257200 / J. Biol. Chem. by Zuhorn (2002)
10.1016/0005-2736(95)80016-9 / Biochim. Biophys. Acta by Farhood (1995)
10.1016/S0005-2736(99)00186-8 / Biochim. Biophys. Acta by Hafez (2000)
10.1016/S0378-5173(02)00337-X / Int. J. Pharm. by Futaki (2002)
10.1016/j.ymthe.2004.01.005 / Mol. Ther. by Akita (2004)
10.1016/S0945-053X(03)00010-6 / Matrix Biol. by Yoneda (2003)
10.1002/jgm.558 / J. Gene Med. by Kopatz (2004)

Dates

Type	When
Created	19 years, 9 months ago (Dec. 2, 2005, 8:13 p.m.)
Deposited	2 years, 3 months ago (May 5, 2023, 2:41 p.m.)
Indexed	1 month, 1 week ago (July 24, 2025, 7:23 a.m.)
Issued	19 years, 7 months ago (Feb. 1, 2006)
Published	19 years, 7 months ago (Feb. 1, 2006)
Published Print	19 years, 7 months ago (Feb. 1, 2006)

Funders 0

None

BibTeX

@article{Khalil_2006, title={High Density of Octaarginine Stimulates Macropinocytosis Leading to Efficient Intracellular Trafficking for Gene Expression}, volume={281}, ISSN={0021-9258}, url={http://dx.doi.org/10.1074/jbc.m503202200}, DOI={10.1074/jbc.m503202200}, number={6}, journal={Journal of Biological Chemistry}, publisher={Elsevier BV}, author={Khalil, Ikramy A. and Kogure, Kentaro and Futaki, Shiroh and Harashima, Hideyoshi}, year={2006}, month=feb, pages={3544–3551} }

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      "DOI": "10.1016/j.bbamem.2004.06.022",
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      "year": "2004",
      "journal-title": "Biochim. Biophys. Acta"
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    {
      "key": "10.1074/jbc.M503202200_bib6",
      "first-page": "1785",
      "volume": "61",
      "author": "Marty",
      "year": "2004",
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      "first-page": "16010",
      "DOI": "10.1074/jbc.272.25.16010",
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      "author": "Vives",
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    },
    {
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      "DOI": "10.1074/jbc.271.30.18188",
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      "author": "Derossi",
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    },
    {
      "key": "10.1074/jbc.M503202200_bib10",
      "doi-asserted-by": "crossref",
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      "DOI": "10.1016/j.ejpb.2004.02.018",
      "volume": "58",
      "author": "Trehin",
      "year": "2004",
      "journal-title": "Eur. J. Pharm. Biopharm."
    },
    {
      "key": "10.1074/jbc.M503202200_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "585",
      "DOI": "10.1074/jbc.M209548200",
      "volume": "278",
      "author": "Richard",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.M503202200_bib12",
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      "DOI": "10.1074/jbc.M303045200",
      "volume": "278",
      "author": "Fittipaldi",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.M503202200_bib18",
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      "first-page": "284",
      "DOI": "10.1016/S1525-0016(03)00122-9",
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      "author": "Ferrari",
      "year": "2003",
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    {
      "key": "10.1074/jbc.M503202200_bib19",
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      "first-page": "5836",
      "DOI": "10.1074/jbc.M007540200",
      "volume": "276",
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      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.M503202200_bib20",
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      "first-page": "2437",
      "DOI": "10.1074/jbc.M110017200",
      "volume": "277",
      "author": "Suzuki",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.M503202200_bib21",
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      "author": "Brooks",
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      "journal-title": "Adv. Drug Deliv. Rev."
    },
    {
      "key": "10.1074/jbc.M503202200_bib22",
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      "first-page": "636",
      "DOI": "10.1038/sj.gt.3302128",
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      "author": "Khalil",
      "year": "2004",
      "journal-title": "Gene Ther."
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    {
      "key": "10.1074/jbc.M503202200_bib23",
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      "first-page": "1569",
      "DOI": "10.1126/science.285.5433.1569",
      "volume": "285",
      "author": "Schwarze",
      "year": "1999",
      "journal-title": "Science"
    },
    {
      "key": "10.1074/jbc.M503202200_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "26204",
      "DOI": "10.1074/jbc.M010625200",
      "volume": "276",
      "author": "Eguchi",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.M503202200_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "1005",
      "DOI": "10.1021/bc015508l",
      "volume": "12",
      "author": "Futaki",
      "year": "2001",
      "journal-title": "Bioconjug. Chem."
    },
    {
      "key": "10.1074/jbc.M503202200_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "317",
      "DOI": "10.1016/j.jconrel.2004.04.024",
      "volume": "98",
      "author": "Kogure",
      "year": "2004",
      "journal-title": "J. Control. Release"
    },
    {
      "key": "10.1074/jbc.M503202200_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "15300",
      "DOI": "10.1074/jbc.M401604200",
      "volume": "280",
      "author": "Richard",
      "year": "2005",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.M503202200_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "35109",
      "DOI": "10.1074/jbc.M301726200",
      "volume": "278",
      "author": "Console",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.M503202200_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "246",
      "DOI": "10.1016/S0003-9861(02)00725-7",
      "volume": "410",
      "author": "Almofti",
      "year": "2003",
      "journal-title": "Arch. Biochem. Biophys."
    },
    {
      "key": "10.1074/jbc.M503202200_bib30",
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      "first-page": "573",
      "DOI": "10.1016/0955-0674(95)80015-8",
      "volume": "7",
      "author": "Lamaze",
      "year": "1995",
      "journal-title": "Curr. Opin. Cell Biol."
    },
    {
      "key": "10.1074/jbc.M503202200_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "37",
      "DOI": "10.1038/nature01451",
      "volume": "422",
      "author": "Conner",
      "year": "2003",
      "journal-title": "Nature"
    },
    {
      "key": "10.1074/jbc.M503202200_bib32",
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      "first-page": "424",
      "DOI": "10.1016/S0962-8924(00)89101-1",
      "volume": "5",
      "author": "Swanson",
      "year": "1995",
      "journal-title": "Trends Cell Biol."
    },
    {
      "key": "10.1074/jbc.M503202200_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "1119",
      "DOI": "10.1083/jcb.200112067",
      "volume": "158",
      "author": "Meier",
      "year": "2002",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1074/jbc.M503202200_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "162",
      "DOI": "10.1038/nrm1017",
      "volume": "4",
      "author": "Parton",
      "year": "2003",
      "journal-title": "Nat. Rev. Mol. Cell Biol."
    },
    {
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      "first-page": "443",
      "DOI": "10.2174/138161280506230110111312",
      "volume": "5",
      "author": "Singh",
      "year": "1999",
      "journal-title": "Curr. Pharm. Des."
    },
    {
      "key": "10.1074/jbc.M503202200_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "18021",
      "DOI": "10.1074/jbc.M111257200",
      "volume": "277",
      "author": "Zuhorn",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
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      "doi-asserted-by": "crossref",
      "first-page": "289",
      "DOI": "10.1016/0005-2736(95)80016-9",
      "volume": "1235",
      "author": "Farhood",
      "year": "1995",
      "journal-title": "Biochim. Biophys. Acta"
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    {
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      "first-page": "107",
      "DOI": "10.1016/S0005-2736(99)00186-8",
      "volume": "1463",
      "author": "Hafez",
      "year": "2000",
      "journal-title": "Biochim. Biophys. Acta"
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      "first-page": "1-7",
      "DOI": "10.1016/S0378-5173(02)00337-X",
      "volume": "245",
      "author": "Futaki",
      "year": "2002",
      "journal-title": "Int. J. Pharm."
    },
    {
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      "first-page": "443",
      "DOI": "10.1016/j.ymthe.2004.01.005",
      "volume": "9",
      "author": "Akita",
      "year": "2004",
      "journal-title": "Mol. Ther."
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      "first-page": "25",
      "DOI": "10.1016/S0945-053X(03)00010-6",
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      "author": "Yoneda",
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