DOI: 10.1074/jbc.m104350200. The Transmembrane Domain of the Alzheimer's β-Secretase (BACE1) Determines Its Late Golgi Localization and Access to β-Amyloid Precursor Protein (APP) Substrate

The Transmembrane Domain of the Alzheimer's β-Secretase (BACE1) Determines Its Late Golgi Localization and Access to β-Amyloid Precursor Protein (APP) Substrate

10.1074/jbc.m104350200

Crossref journal-article

Elsevier BV

Journal of Biological Chemistry (78)

Bibliography

Yan, R., Han, P., Miao, H., Greengard, P., & Xu, H. (2001). The Transmembrane Domain of the Alzheimerâs Î²-Secretase (BACE1) Determines Its Late Golgi Localization and Access to Î²-Amyloid Precursor Protein (APP) Substrate. Journal of Biological Chemistry, 276(39), 36788â36796.

Authors 5

Riqiang Yan (first)
Ping Han (additional)
Huiyi Miao (additional)
Paul Greengard (additional)
Huaxi Xu (additional)

References 40 Referenced 142

10.1038/399a023 / Nature by Selkoe (1999)
{'key': '10.1074/jbc.M104350200_bib2', 'first-page': '289', 'volume': '92', 'author': 'Youkin', 'year': '1998', 'journal-title': 'J. Physiol.'} / J. Physiol. by Youkin (1998)
10.2741/Greenfield / Front. Biosci. by Greenfield (2000)
10.1016/0006-291X(84)91209-9 / Biochem. Biophys. Res. Commun. by Glenner (1984)
10.1016/S0166-2236(96)01030-2 / Trends Neurosci. by Hardy (1997)
10.1126/science.1691865 / Science by Sisodia (1990)
10.1126/science.286.5440.735 / Science by Vassar (1999)
10.1006/mcne.1999.0811 / Mol. Cell. Neurosci. by Hussain (1999)
10.1038/990107 / Nature by Yan (1999)
10.1038/990114 / Nature by Sinha (1999)
10.1073/pnas.97.4.1456 / Proc. Natl. Acad. Sci. U. S. A. by Lin (2000)
10.1074/jbc.M005339200 / J. Biol. Chem. by Bennett (2000)
10.1074/jbc.M006947200 / J. Biol. Chem. by Creemers (2001)
10.1074/jbc.M003202200 / J. Biol. Chem. by Capell (2000)
10.1074/jbc.M011116200 / J. Biol. Chem. by Walter (2001)
10.1074/jbc.M004175200 / J. Biol. Chem. by Huse (2000)
10.1074/jbc.M009899200 / J. Biol. Chem by Benjannet (2001)
10.1074/jbc.M009200200 / J. Biol. Chem. by Shi (2001)
10.1038/nm0997-1021 / Nat. Med. by Cook (1997)
10.1038/nm0997-1016 / Nat. Med. by Hartmann (1997)
10.1074/jbc.272.26.16085 / J. Biol. Chem. by Wild-Bode (1997)
10.1073/pnas.96.2.742 / Proc. Natl. Acad. Sci. U. S. A. by Greenfield (1997)
10.1073/pnas.87.15.6003 / Proc. Natl. Acad. Sci. U. S. A. by Buxbaum (1990)
10.1083/jcb.117.6.1171 / J. Cell Biol. by Wong (1992)
10.1042/bj3010069 / Biochem. J. by Horn (1994)
10.1016/S0021-9258(17)32449-3 / .J. Biol. Chem. by Koo (1994)
10.1083/jcb.122.6.1169 / J. Cell Biol. by Xu (1993)
10.1073/pnas.94.8.3748 / Proc. Natl. Acad. Sci. U. S. A. by Xu (1997)
10.1523/JNEUROSCI.21-08-02561.2001 / J. Neurosci. by Gasparini (2001)
10.1016/0092-8674(89)90177-3 / Cell by Weidemann (1989)
10.1016/S0021-9258(19)39742-X / J. Biol. Chem. by Chen (1990)
10.1093/hmg/7.13.2063 / Hum. Mol. Genet. by Petris (1998)
10.1038/85064 / Nat. Neurosci. by Cai (2001)
10.1038/85059 / Nat. Neurosci. by Luo (2001)
10.1126/science.8362242 / Science by Bretscher (1993)
10.1016/0955-0674(93)90129-E / Curr. Opin. Cell Biol. by Machamer (1993)
Yan, R., Munzner, J. B., Shuck, M. E., and Bienkowski, M. J. (June 22, 2001) J. Biol. Chem.10.1074/jbc.M105583200
10.1074/jbc.275.2.1261 / J. Biol. Chem. by Watson (2000)
10.1074/jbc.274.51.36781 / J. Biol. Chem. by Teuchert (1999)
10.1038/71944 / Nat. Biotechnol. by Gruninger-Leitch (2000)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:59 a.m.)
Deposited	3 years, 8 months ago (Dec. 16, 2021, 11:29 p.m.)
Indexed	2 months, 4 weeks ago (June 5, 2025, 7:04 p.m.)
Issued	24 years ago (Sept. 1, 2001)
Published	24 years ago (Sept. 1, 2001)
Published Print	24 years ago (Sept. 1, 2001)

Funders 0

None

BibTeX

@article{Yan_2001, title={The Transmembrane Domain of the Alzheimer’s β-Secretase (BACE1) Determines Its Late Golgi Localization and Access to β-Amyloid Precursor Protein (APP) Substrate}, volume={276}, ISSN={0021-9258}, url={http://dx.doi.org/10.1074/jbc.m104350200}, DOI={10.1074/jbc.m104350200}, number={39}, journal={Journal of Biological Chemistry}, publisher={Elsevier BV}, author={Yan, Riqiang and Han, Ping and Miao, Huiyi and Greengard, Paul and Xu, Huaxi}, year={2001}, month=sep, pages={36788–36796} }

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      "DOI": "10.1038/990107",
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      "volume": "97",
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      "key": "10.1074/jbc.M104350200_bib24",
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      "first-page": "1171",
      "DOI": "10.1083/jcb.117.6.1171",
      "volume": "117",
      "author": "Wong",
      "year": "1992",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1074/jbc.M104350200_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "69",
      "DOI": "10.1042/bj3010069",
      "volume": "301",
      "author": "Horn",
      "year": "1994",
      "journal-title": "Biochem. J."
    },
    {
      "key": "10.1074/jbc.M104350200_bib26",
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      "first-page": "17386",
      "DOI": "10.1016/S0021-9258(17)32449-3",
      "volume": "269",
      "author": "Koo",
      "year": "1994",
      "journal-title": ".J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.M104350200_bib27",
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      "first-page": "169",
      "DOI": "10.1083/jcb.122.6.1169",
      "volume": "122",
      "author": "Xu",
      "year": "1993",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1074/jbc.M104350200_bib28",
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      "first-page": "3748",
      "DOI": "10.1073/pnas.94.8.3748",
      "volume": "94",
      "author": "Xu",
      "year": "1997",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1074/jbc.M104350200_bib29",
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      "first-page": "2561",
      "DOI": "10.1523/JNEUROSCI.21-08-02561.2001",
      "volume": "21",
      "author": "Gasparini",
      "year": "2001",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1074/jbc.M104350200_bib30",
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      "first-page": "115",
      "DOI": "10.1016/0092-8674(89)90177-3",
      "volume": "57",
      "author": "Weidemann",
      "year": "1989",
      "journal-title": "Cell"
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    {
      "key": "10.1074/jbc.M104350200_bib31",
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      "first-page": "3116",
      "DOI": "10.1016/S0021-9258(19)39742-X",
      "volume": "265",
      "author": "Chen",
      "year": "1990",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.M104350200_bib32",
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      "first-page": "2063",
      "DOI": "10.1093/hmg/7.13.2063",
      "volume": "7",
      "author": "Petris",
      "year": "1998",
      "journal-title": "Hum. Mol. Genet."
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      "key": "10.1074/jbc.M104350200_bib33",
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      "first-page": "233",
      "DOI": "10.1038/85064",
      "volume": "4",
      "author": "Cai",
      "year": "2001",
      "journal-title": "Nat. Neurosci."
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      "first-page": "231",
      "DOI": "10.1038/85059",
      "volume": "4",
      "author": "Luo",
      "year": "2001",
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      "first-page": "1280",
      "DOI": "10.1126/science.8362242",
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  ],
  "URL": "http://dx.doi.org/10.1074/jbc.M104350200",
  "relation": {},
  "ISSN": [
    "0021-9258"
  ],
  "subject": [],
  "container-title-short": "Journal of Biological Chemistry",
  "published": {
    "date-parts": [
      [
        2001,
        9
      ]
    ]
  }
}