DOI: 10.1074/jbc.m100395200. Crystal Structure of the Mitotic Spindle Kinesin Eg5 Reveals a Novel Conformation of the Neck-linker

Crystal Structure of the Mitotic Spindle Kinesin Eg5 Reveals a Novel Conformation of the Neck-linker

10.1074/jbc.m100395200

Crossref journal-article

Elsevier BV

Journal of Biological Chemistry (78)

Bibliography

Turner, J., Anderson, R., Guo, J., Beraud, C., Fletterick, R., & Sakowicz, R. (2001). Crystal Structure of the Mitotic Spindle Kinesin Eg5 Reveals a Novel Conformation of the Neck-linker. Journal of Biological Chemistry, 276(27), 25496â25502.

Authors 6

Jennifer Turner (first)
Robert Anderson (additional)
Jun Guo (additional)
Christophe Beraud (additional)
Robert Fletterick (additional)
Roman Sakowicz (additional)

References 29 Referenced 187

10.1016/S0092-8674(00)00044-1 / Cell by Heald (2000)
10.1083/jcb.144.1.125 / J. Cell Biol. by Sharp (1999)
10.1016/S0960-9822(07)00370-3 / Curr. Biol. by Walczak (1998)
10.1038/9025 / Nat. Cell Biol. by Sharp (1999)
10.1126/science.286.5441.971 / Science by Mayer (1999)
10.1083/jcb.150.5.975 / J. Cell Biol. by Kapoor (2000)
10.1016/0092-8674(90)90350-N / Cell by Enos (1990)
10.1038/347563a0 / Nature by Hagan (1990)
10.1083/jcb.118.1.109 / J. Cell Biol. by Hoyt (1992)
10.1083/jcb.123.3.665 / J. Cell Biol. by Heck (1993)
{'key': '10.1074/jbc.M100395200_bib11', 'first-page': '3395', 'volume': '11', 'author': 'LeGuellec', 'year': '1991', 'journal-title': 'Mol. Cell. Biol.'} / Mol. Cell. Biol. by LeGuellec (1991)
10.1038/359540a0 / Nature by Swain (1992)
10.1016/0092-8674(95)90142-6 / Cell by Blangy (1995)
10.1146/annurev.cellbio.13.1.745 / Annu. Rev. Cell Dev. Biol. by Vale (1997)
10.1021/bi952318n / Biochemistry by Lockhart (1996)
10.1006/jmbi.1997.1319 / J. Mol. Biol. by Crevel (1997)
10.1038/379270a0 / Nature by Kashina (1996)
10.1073/pnas.92.10.4289 / Proc. Natl. Acad. U. S. A. by Swain (1995)
10.1126/science.288.5463.88 / Science by Vale (2000)
{'key': '10.1074/jbc.M100395200_bib20', 'first-page': '307', 'volume': '276', 'author': 'Otwinowski', 'year': '1997'} by Otwinowski (1997)
10.1126/science.235.4787.458 / Science by Brunger (1987)
10.1021/bi972504o / Biochemistry by Gulick (1998)
10.1038/380550a0 / Nature by Kull (1996)
10.1038/380555a0 / Nature by Sablin (1996)
10.1038/35078000 / Nature by Kikkawa (2001)
10.1021/bi9722498 / Biochemistry by Sack (1997)
10.1016/S0960-9822(00)00316-X / Curr. Biol. by Case (2000)
10.1038/45483 / Nature by Rice (1999)
10.1093/emboj/19.20.5308 / EMBO J. by Hirose (2000)

Dates

Type	When
Created	23 years ago (July 26, 2002, 11:16 a.m.)
Deposited	3 years, 7 months ago (Jan. 5, 2022, 1:52 p.m.)
Indexed	1 month, 3 weeks ago (July 1, 2025, 4:05 a.m.)
Issued	24 years, 7 months ago (Jan. 1, 2001)
Published	24 years, 7 months ago (Jan. 1, 2001)
Published Print	24 years, 7 months ago (Jan. 1, 2001)

Funders 0

None

BibTeX

@article{Turner_2001, title={Crystal Structure of the Mitotic Spindle Kinesin Eg5 Reveals a Novel Conformation of the Neck-linker}, volume={276}, ISSN={0021-9258}, url={http://dx.doi.org/10.1074/jbc.m100395200}, DOI={10.1074/jbc.m100395200}, number={27}, journal={Journal of Biological Chemistry}, publisher={Elsevier BV}, author={Turner, Jennifer and Anderson, Robert and Guo, Jun and Beraud, Christophe and Fletterick, Robert and Sakowicz, Roman}, year={2001}, month=jan, pages={25496–25502} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        1
      ]
    ],
    "date-time": "2025-07-01T08:05:23Z",
    "timestamp": 1751357123671
  },
  "reference-count": 29,
  "publisher": "Elsevier BV",
  "issue": "27",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2001,
            1,
            1
          ]
        ],
        "date-time": "2001-01-01T00:00:00Z",
        "timestamp": 978307200000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2020,
            9,
            22
          ]
        ],
        "date-time": "2020-09-22T00:00:00Z",
        "timestamp": 1600732800000
      },
      "content-version": "vor",
      "delay-in-days": 7204,
      "URL": "http://creativecommons.org/licenses/by/4.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2001,
        1
      ]
    ]
  },
  "DOI": "10.1074/jbc.m100395200",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        26
      ]
    ],
    "date-time": "2002-07-26T15:16:07Z",
    "timestamp": 1027696567000
  },
  "page": "25496-25502",
  "source": "Crossref",
  "is-referenced-by-count": 187,
  "title": "Crystal Structure of the Mitotic Spindle Kinesin Eg5 Reveals a Novel Conformation of the Neck-linker",
  "prefix": "10.1016",
  "volume": "276",
  "author": [
    {
      "given": "Jennifer",
      "family": "Turner",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Robert",
      "family": "Anderson",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Jun",
      "family": "Guo",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Christophe",
      "family": "Beraud",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Robert",
      "family": "Fletterick",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Roman",
      "family": "Sakowicz",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1074/jbc.M100395200_bib1",
      "doi-asserted-by": "crossref",
      "first-page": "399",
      "DOI": "10.1016/S0092-8674(00)00044-1",
      "volume": "102",
      "author": "Heald",
      "year": "2000",
      "journal-title": "Cell"
    },
    {
      "key": "10.1074/jbc.M100395200_bib2",
      "doi-asserted-by": "crossref",
      "first-page": "125",
      "DOI": "10.1083/jcb.144.1.125",
      "volume": "144",
      "author": "Sharp",
      "year": "1999",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1074/jbc.M100395200_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "903",
      "DOI": "10.1016/S0960-9822(07)00370-3",
      "volume": "8",
      "author": "Walczak",
      "year": "1998",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1074/jbc.M100395200_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "51",
      "DOI": "10.1038/9025",
      "volume": "1",
      "author": "Sharp",
      "year": "1999",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "10.1074/jbc.M100395200_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "971",
      "DOI": "10.1126/science.286.5441.971",
      "volume": "286",
      "author": "Mayer",
      "year": "1999",
      "journal-title": "Science"
    },
    {
      "key": "10.1074/jbc.M100395200_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "975",
      "DOI": "10.1083/jcb.150.5.975",
      "volume": "150",
      "author": "Kapoor",
      "year": "2000",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1074/jbc.M100395200_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "1019",
      "DOI": "10.1016/0092-8674(90)90350-N",
      "volume": "60",
      "author": "Enos",
      "year": "1990",
      "journal-title": "Cell"
    },
    {
      "key": "10.1074/jbc.M100395200_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "563",
      "DOI": "10.1038/347563a0",
      "volume": "347",
      "author": "Hagan",
      "year": "1990",
      "journal-title": "Nature"
    },
    {
      "key": "10.1074/jbc.M100395200_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "109",
      "DOI": "10.1083/jcb.118.1.109",
      "volume": "118",
      "author": "Hoyt",
      "year": "1992",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1074/jbc.M100395200_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "655",
      "DOI": "10.1083/jcb.123.3.665",
      "volume": "123",
      "author": "Heck",
      "year": "1993",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1074/jbc.M100395200_bib11",
      "first-page": "3395",
      "volume": "11",
      "author": "LeGuellec",
      "year": "1991",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1074/jbc.M100395200_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "540",
      "DOI": "10.1038/359540a0",
      "volume": "359",
      "author": "Swain",
      "year": "1992",
      "journal-title": "Nature"
    },
    {
      "key": "10.1074/jbc.M100395200_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "1159",
      "DOI": "10.1016/0092-8674(95)90142-6",
      "volume": "83",
      "author": "Blangy",
      "year": "1995",
      "journal-title": "Cell"
    },
    {
      "key": "10.1074/jbc.M100395200_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "745",
      "DOI": "10.1146/annurev.cellbio.13.1.745",
      "volume": "13",
      "author": "Vale",
      "year": "1997",
      "journal-title": "Annu. Rev. Cell Dev. Biol."
    },
    {
      "key": "10.1074/jbc.M100395200_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "2365",
      "DOI": "10.1021/bi952318n",
      "volume": "35",
      "author": "Lockhart",
      "year": "1996",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1074/jbc.M100395200_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "160",
      "DOI": "10.1006/jmbi.1997.1319",
      "volume": "273",
      "author": "Crevel",
      "year": "1997",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1074/jbc.M100395200_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "270",
      "DOI": "10.1038/379270a0",
      "volume": "379",
      "author": "Kashina",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "10.1074/jbc.M100395200_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "4289",
      "DOI": "10.1073/pnas.92.10.4289",
      "volume": "92",
      "author": "Swain",
      "year": "1995",
      "journal-title": "Proc. Natl. Acad. U. S. A."
    },
    {
      "key": "10.1074/jbc.M100395200_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "88",
      "DOI": "10.1126/science.288.5463.88",
      "volume": "288",
      "author": "Vale",
      "year": "2000",
      "journal-title": "Science"
    },
    {
      "key": "10.1074/jbc.M100395200_bib20",
      "first-page": "307",
      "volume": "276",
      "author": "Otwinowski",
      "year": "1997"
    },
    {
      "key": "10.1074/jbc.M100395200_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "458",
      "DOI": "10.1126/science.235.4787.458",
      "volume": "235",
      "author": "Brunger",
      "year": "1987",
      "journal-title": "Science"
    },
    {
      "key": "10.1074/jbc.M100395200_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "1769",
      "DOI": "10.1021/bi972504o",
      "volume": "37",
      "author": "Gulick",
      "year": "1998",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1074/jbc.M100395200_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "550",
      "DOI": "10.1038/380550a0",
      "volume": "380",
      "author": "Kull",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "10.1074/jbc.M100395200_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "555",
      "DOI": "10.1038/380555a0",
      "volume": "380",
      "author": "Sablin",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "10.1074/jbc.M100395200_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "439",
      "DOI": "10.1038/35078000",
      "volume": "411",
      "author": "Kikkawa",
      "year": "2001",
      "journal-title": "Nature"
    },
    {
      "key": "10.1074/jbc.M100395200_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "16155",
      "DOI": "10.1021/bi9722498",
      "volume": "36",
      "author": "Sack",
      "year": "1997",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1074/jbc.M100395200_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "157",
      "DOI": "10.1016/S0960-9822(00)00316-X",
      "volume": "10",
      "author": "Case",
      "year": "2000",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1074/jbc.M100395200_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "778",
      "DOI": "10.1038/45483",
      "volume": "402",
      "author": "Rice",
      "year": "1999",
      "journal-title": "Nature"
    },
    {
      "key": "10.1074/jbc.M100395200_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "5308",
      "DOI": "10.1093/emboj/19.20.5308",
      "volume": "19",
      "author": "Hirose",
      "year": "2000",
      "journal-title": "EMBO J."
    }
  ],
  "container-title": "Journal of Biological Chemistry",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0021925820796407?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0021925820796407?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://syndication.highwire.org/content/doi/10.1074/jbc.M100395200",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2022,
        1,
        5
      ]
    ],
    "date-time": "2022-01-05T18:52:50Z",
    "timestamp": 1641408770000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0021925820796407"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2001,
        1
      ]
    ]
  },
  "references-count": 29,
  "journal-issue": {
    "issue": "27",
    "published-print": {
      "date-parts": [
        [
          2001,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "S0021925820796407"
  ],
  "URL": "http://dx.doi.org/10.1074/jbc.M100395200",
  "relation": {},
  "ISSN": [
    "0021-9258"
  ],
  "subject": [],
  "container-title-short": "Journal of Biological Chemistry",
  "published": {
    "date-parts": [
      [
        2001,
        1
      ]
    ]
  }
}