DOI: 10.1074/jbc.c300186200. Structure of a c-Kit Product Complex Reveals the Basis for Kinase Transactivation

Structure of a c-Kit Product Complex Reveals the Basis for Kinase Transactivation

10.1074/jbc.c300186200

Crossref journal-article

Elsevier BV

Journal of Biological Chemistry (78)

Authors 10

Clifford D. Mol (first)
Kheng B. Lim (additional)
Vandana Sridhar (additional)
Hua Zou (additional)
Ellen Y.T. Chien (additional)
Bi-Ching Sang (additional)
Jacek Nowakowski (additional)
Daniel B. Kassel (additional)
Ciarán N. Cronin (additional)
Duncan E. McRee (additional)

References 30 Referenced 203

10.1038/323226a0 / Nature by Yarden (1986)
10.1016/0092-8674(90)90801-K / Cell by Ullrich (1990)
10.1002/j.1460-2075.1987.tb02655.x / EMBO J. by Yarden (1987)
10.1038/320277a0 / Nature by Coussens (1986)
10.1073/pnas.86.13.4917 / Proc. Natl. Acad. Sci. U. S. A. by Claesson-Welsh (1989)
10.1182/blood.V82.4.1110.1110 / Blood by Rosnet (1993)
10.1016/0092-8674(95)90404-2 / Cell by Heldin (1995)
10.1016/S0092-8674(00)81469-5 / Cell by Weiss (1998)
10.1038/35077225 / Nature by Blume-Jensen (2001)
10.1128/MCB.18.4.2089 / Mol. Cell. Biol. by Kozlowski (1998)
10.1038/320415a0 / Nature by Snyder (1986)
10.1016/0955-0674(91)90111-B / Curr. Opin. Cell Biol. by Besmer (1991)
10.1182/blood.V91.4.1101 / Blood by Lyman (1998)
10.1016/S1357-2725(99)00076-X / Int. J. Biochem. Cell Biol. by Ashman (1999)
10.1016/S0027-5107(01)00117-8 / Mutat. Res. by Kitamura (2001)
10.1126/science.279.5350.577 / Science by Hirota (1998)
10.1038/1209 / Nat. Genet. by Hirota (1998)
10.1016/S0002-9440(10)65419-3 / Am. J. Pathol. by Tian (1999)
10.1074/jbc.273.20.11987 / J. Biol. Chem. by Hubbard (1998)
10.1038/ng0696-233 / Nat. Genet. by Naski (1996)
10.1128/MCB.16.8.4081 / Mol. Cell. Biol. by Webster (1996)
10.1073/pnas.94.21.11445 / Proc. Natl. Acad. Sci. U. S. A. by Jeffers (1997)
10.1038/ng0395-321 / Nat. Genet. by Tavormina (1995)
10.1126/science.289.5486.1938 / Science by Schindler (2000)
10.1038/sj.onc.1206120 / Oncogene by Zermati (2003)
10.1016/S0076-6879(97)76066-X / Methods Enzymol. by Otwinowski (1997)
10.1107/S0108767393007597 / Acta Crystallogr. Sect. A by Navaza (1994)
10.1107/S0907444996012255 / Acta Crystallogr. Sect. D Biol. Crystallogr. by Murshudov (1997)
10.1006/jsbi.1999.4094 / J. Struct. Biol. by McRee (1999)
10.1016/S0092-8674(02)00741-9 / Cell by Huse (2002)

Dates

Type	When
Created	22 years ago (Aug. 15, 2003, 4:14 p.m.)
Deposited	3 years, 7 months ago (Jan. 5, 2022, 4:05 p.m.)
Indexed	18 hours, 50 minutes ago (Aug. 29, 2025, 5:41 a.m.)
Issued	22 years ago (Aug. 1, 2003)
Published	22 years ago (Aug. 1, 2003)
Published Print	22 years ago (Aug. 1, 2003)

Funders 0

None

BibTeX

@article{Mol_2003, title={Structure of a c-Kit Product Complex Reveals the Basis for Kinase Transactivation}, volume={278}, ISSN={0021-9258}, url={http://dx.doi.org/10.1074/jbc.c300186200}, DOI={10.1074/jbc.c300186200}, number={34}, journal={Journal of Biological Chemistry}, publisher={Elsevier BV}, author={Mol, Clifford D. and Lim, Kheng B. and Sridhar, Vandana and Zou, Hua and Chien, Ellen Y.T. and Sang, Bi-Ching and Nowakowski, Jacek and Kassel, Daniel B. and Cronin, Ciarán N. and McRee, Duncan E.}, year={2003}, month=aug, pages={31461–31464} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        29
      ]
    ],
    "date-time": "2025-08-29T09:41:31Z",
    "timestamp": 1756460491388
  },
  "reference-count": 30,
  "publisher": "Elsevier BV",
  "issue": "34",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2003,
            8,
            1
          ]
        ],
        "date-time": "2003-08-01T00:00:00Z",
        "timestamp": 1059696000000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2020,
            9,
            29
          ]
        ],
        "date-time": "2020-09-29T00:00:00Z",
        "timestamp": 1601337600000
      },
      "content-version": "vor",
      "delay-in-days": 6269,
      "URL": "http://creativecommons.org/licenses/by/4.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2003,
        8
      ]
    ]
  },
  "DOI": "10.1074/jbc.c300186200",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2003,
        8,
        15
      ]
    ],
    "date-time": "2003-08-15T20:14:13Z",
    "timestamp": 1060978453000
  },
  "page": "31461-31464",
  "source": "Crossref",
  "is-referenced-by-count": 203,
  "title": "Structure of a c-Kit Product Complex Reveals the Basis for Kinase Transactivation",
  "prefix": "10.1016",
  "volume": "278",
  "author": [
    {
      "given": "Clifford D.",
      "family": "Mol",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Kheng B.",
      "family": "Lim",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Vandana",
      "family": "Sridhar",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Hua",
      "family": "Zou",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Ellen Y.T.",
      "family": "Chien",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Bi-Ching",
      "family": "Sang",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Jacek",
      "family": "Nowakowski",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Daniel B.",
      "family": "Kassel",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Ciar\u00e1n N.",
      "family": "Cronin",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Duncan E.",
      "family": "McRee",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1074/jbc.C300186200_bib1",
      "doi-asserted-by": "crossref",
      "first-page": "226",
      "DOI": "10.1038/323226a0",
      "volume": "323",
      "author": "Yarden",
      "year": "1986",
      "journal-title": "Nature"
    },
    {
      "key": "10.1074/jbc.C300186200_bib2",
      "doi-asserted-by": "crossref",
      "first-page": "203",
      "DOI": "10.1016/0092-8674(90)90801-K",
      "volume": "61",
      "author": "Ullrich",
      "year": "1990",
      "journal-title": "Cell"
    },
    {
      "key": "10.1074/jbc.C300186200_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "3341",
      "DOI": "10.1002/j.1460-2075.1987.tb02655.x",
      "volume": "6",
      "author": "Yarden",
      "year": "1987",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1074/jbc.C300186200_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "277",
      "DOI": "10.1038/320277a0",
      "volume": "320",
      "author": "Coussens",
      "year": "1986",
      "journal-title": "Nature"
    },
    {
      "key": "10.1074/jbc.C300186200_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "4917",
      "DOI": "10.1073/pnas.86.13.4917",
      "volume": "86",
      "author": "Claesson-Welsh",
      "year": "1989",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1074/jbc.C300186200_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "1110",
      "DOI": "10.1182/blood.V82.4.1110.1110",
      "volume": "82",
      "author": "Rosnet",
      "year": "1993",
      "journal-title": "Blood"
    },
    {
      "key": "10.1074/jbc.C300186200_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "213",
      "DOI": "10.1016/0092-8674(95)90404-2",
      "volume": "80",
      "author": "Heldin",
      "year": "1995",
      "journal-title": "Cell"
    },
    {
      "key": "10.1074/jbc.C300186200_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "277",
      "DOI": "10.1016/S0092-8674(00)81469-5",
      "volume": "94",
      "author": "Weiss",
      "year": "1998",
      "journal-title": "Cell"
    },
    {
      "key": "10.1074/jbc.C300186200_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "355",
      "DOI": "10.1038/35077225",
      "volume": "411",
      "author": "Blume-Jensen",
      "year": "2001",
      "journal-title": "Nature"
    },
    {
      "key": "10.1074/jbc.C300186200_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "2089",
      "DOI": "10.1128/MCB.18.4.2089",
      "volume": "18",
      "author": "Kozlowski",
      "year": "1998",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1074/jbc.C300186200_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "415",
      "DOI": "10.1038/320415a0",
      "volume": "320",
      "author": "Snyder",
      "year": "1986",
      "journal-title": "Nature"
    },
    {
      "key": "10.1074/jbc.C300186200_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "939",
      "DOI": "10.1016/0955-0674(91)90111-B",
      "volume": "3",
      "author": "Besmer",
      "year": "1991",
      "journal-title": "Curr. Opin. Cell Biol."
    },
    {
      "key": "10.1074/jbc.C300186200_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "1101",
      "DOI": "10.1182/blood.V91.4.1101",
      "volume": "91",
      "author": "Lyman",
      "year": "1998",
      "journal-title": "Blood"
    },
    {
      "key": "10.1074/jbc.C300186200_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "1037",
      "DOI": "10.1016/S1357-2725(99)00076-X",
      "volume": "31",
      "author": "Ashman",
      "year": "1999",
      "journal-title": "Int. J. Biochem. Cell Biol."
    },
    {
      "key": "10.1074/jbc.C300186200_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "165",
      "DOI": "10.1016/S0027-5107(01)00117-8",
      "volume": "477",
      "author": "Kitamura",
      "year": "2001",
      "journal-title": "Mutat. Res."
    },
    {
      "key": "10.1074/jbc.C300186200_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "577",
      "DOI": "10.1126/science.279.5350.577",
      "volume": "279",
      "author": "Hirota",
      "year": "1998",
      "journal-title": "Science"
    },
    {
      "key": "10.1074/jbc.C300186200_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "323",
      "DOI": "10.1038/1209",
      "volume": "19",
      "author": "Hirota",
      "year": "1998",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1074/jbc.C300186200_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "1643",
      "DOI": "10.1016/S0002-9440(10)65419-3",
      "volume": "154",
      "author": "Tian",
      "year": "1999",
      "journal-title": "Am. J. Pathol."
    },
    {
      "key": "10.1074/jbc.C300186200_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "11987",
      "DOI": "10.1074/jbc.273.20.11987",
      "volume": "273",
      "author": "Hubbard",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.C300186200_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "233",
      "DOI": "10.1038/ng0696-233",
      "volume": "13",
      "author": "Naski",
      "year": "1996",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1074/jbc.C300186200_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "4081",
      "DOI": "10.1128/MCB.16.8.4081",
      "volume": "16",
      "author": "Webster",
      "year": "1996",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1074/jbc.C300186200_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "11445",
      "DOI": "10.1073/pnas.94.21.11445",
      "volume": "94",
      "author": "Jeffers",
      "year": "1997",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1074/jbc.C300186200_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "321",
      "DOI": "10.1038/ng0395-321",
      "volume": "9",
      "author": "Tavormina",
      "year": "1995",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1074/jbc.C300186200_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "1938",
      "DOI": "10.1126/science.289.5486.1938",
      "volume": "289",
      "author": "Schindler",
      "year": "2000",
      "journal-title": "Science"
    },
    {
      "key": "10.1074/jbc.C300186200_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "660",
      "DOI": "10.1038/sj.onc.1206120",
      "volume": "22",
      "author": "Zermati",
      "year": "2003",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1074/jbc.C300186200_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "307",
      "DOI": "10.1016/S0076-6879(97)76066-X",
      "volume": "276",
      "author": "Otwinowski",
      "year": "1997",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "10.1074/jbc.C300186200_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "157",
      "DOI": "10.1107/S0108767393007597",
      "volume": "50",
      "author": "Navaza",
      "year": "1994",
      "journal-title": "Acta Crystallogr. Sect. A"
    },
    {
      "key": "10.1074/jbc.C300186200_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "240",
      "DOI": "10.1107/S0907444996012255",
      "volume": "53",
      "author": "Murshudov",
      "year": "1997",
      "journal-title": "Acta Crystallogr. Sect. D Biol. Crystallogr."
    },
    {
      "key": "10.1074/jbc.C300186200_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "156",
      "DOI": "10.1006/jsbi.1999.4094",
      "volume": "125",
      "author": "McRee",
      "year": "1999",
      "journal-title": "J. Struct. Biol."
    },
    {
      "key": "10.1074/jbc.C300186200_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "275",
      "DOI": "10.1016/S0092-8674(02)00741-9",
      "volume": "109",
      "author": "Huse",
      "year": "2002",
      "journal-title": "Cell"
    }
  ],
  "container-title": "Journal of Biological Chemistry",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0021925820839337?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0021925820839337?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://syndication.highwire.org/content/doi/10.1074/jbc.C300186200",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2022,
        1,
        5
      ]
    ],
    "date-time": "2022-01-05T21:05:04Z",
    "timestamp": 1641416704000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0021925820839337"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2003,
        8
      ]
    ]
  },
  "references-count": 30,
  "journal-issue": {
    "issue": "34",
    "published-print": {
      "date-parts": [
        [
          2003,
          8
        ]
      ]
    }
  },
  "alternative-id": [
    "S0021925820839337"
  ],
  "URL": "http://dx.doi.org/10.1074/jbc.C300186200",
  "relation": {},
  "ISSN": [
    "0021-9258"
  ],
  "subject": [],
  "container-title-short": "Journal of Biological Chemistry",
  "published": {
    "date-parts": [
      [
        2003,
        8
      ]
    ]
  }
}