DOI: 10.1074/jbc.c000165200. Evidence that the β-Amyloid Plaques of Alzheimer's Disease Represent the Redox-silencing and Entombment of Aβ by Zinc

Evidence that the β-Amyloid Plaques of Alzheimer's Disease Represent the Redox-silencing and Entombment of Aβ by Zinc

10.1074/jbc.c000165200

Crossref journal-article

Elsevier BV

Journal of Biological Chemistry (78)

Bibliography

Cuajungco, M. P., Goldstein, L. E., Nunomura, A., Smith, M. A., Lim, J. T., Atwood, C. S., Huang, X., Farrag, Y. W., Perry, G., & Bush, A. I. (2000). Evidence that the Î²-Amyloid Plaques of Alzheimerâs Disease Represent the Redox-silencing and Entombment of AÎ² by Zinc. Journal of Biological Chemistry, 275(26), 19439â19442.

Authors 10

Math P. Cuajungco (first)
Lee E. Goldstein (additional)
Akihiko Nunomura (additional)
Mark A. Smith (additional)
James T. Lim (additional)
Craig S. Atwood (additional)
Xudong Huang (additional)
Yasser W. Farrag (additional)
George Perry (additional)
Ashley I. Bush (additional)

References 31 Referenced 323

10.1016/S0006-291X(84)80190-4 / Biochem. Biophys. Res. Commun. by Glenner (1984)
10.1038/325733a0 / Nature by Kang (1987)
{'key': '10.1074/jbc.C000165200_bib3', 'first-page': '309', 'volume': '36', 'author': 'Atwood', 'year': '1999', 'journal-title': 'Metal Ions Biol. Syst.'} / Metal Ions Biol. Syst. by Atwood (1999)
10.1046/j.1471-4159.1998.70052212.x / J. Neurochem. by Smith (1998)
10.1074/jbc.274.52.37111 / J. Biol. Chem. by Huang (1999)
10.1021/bi990438f / Biochemistry by Huang (1999)
10.1097/00005072-198107000-00009 / J. Neuropathol. Exp. Neurol. by Vaughan (1981)
10.1016/S0022-510X(98)00092-6 / J. Neurol. Sci. by Lovell (1998)
10.1097/00005072-199311000-00006 / J. Neuropathol. Exp. Neurol. by Hyman (1993)
10.1002/1531-8249(199912)46:6<860::AID-ANA8>3.0.CO;2-M / Ann. Neurol. by McLean (1999)
10.1074/jbc.271.34.20631 / J. Biol. Chem. by Roher (1996)
10.1016/S0006-8993(99)02096-X / Brain Res. by Suh (2000)
10.1523/JNEUROSCI.19-01-00001.1999 / J. Neurosci. by Lee (1999)
10.1016/S0021-9258(17)32694-7 / J. Biol. Chem. by Bush (1994)
10.1126/science.8073293 / Science by Bush (1994)
10.1074/jbc.272.42.26464 / J. Biol. Chem. by Huang (1997)
10.1074/jbc.274.33.23223 / J. Biol. Chem. by Cherny (1999)
10.1523/JNEUROSCI.19-06-01959.1999 / J. Neurosci. by Nunomura (1999)
10.1016/0003-2697(91)90229-M / Anal. Biochem. by Campbell (1991)
10.1523/JNEUROSCI.17-08-02653.1997 / J. Neurosci. by Smith (1997)
10.1016/S0006-8993(99)01114-2 / Brain Res. by Lovell (1999)
10.1016/0005-2736(94)90039-6 / Biochim. Biophys. Acta by Huang (1994)
Atwood, C. S., Scarpa, R. C., Huang, X., Moir, R. D., Jones, W. D., Fairlie, D. P., Tanzi, R. E., and Bush, A. I. (2000) J. Neurochem., in press
10.1006/exnr.1998.7009 / Exp. Neurol. by Penkowa (1999)
10.1073/pnas.95.7.3478 / Proc. Natl. Acad. Sci. U. S. A. by Maret (1998)
10.1016/S0074-7742(08)60279-2 / Int. Rev. Neurobiol. by Frederickson (1989)
10.1038/1243 / Nat. Genet. by Blacker (1998)
10.1046/j.1471-4159.1997.69010299.x / J. Neurochem. by Du (1997)
10.1021/bi982437d / Biochemistry by Moir (1999)
10.1038/ng0996-55 / Nat. Genet. by Miyata (1996)
10.1016/S0891-5849(99)00102-1 / Free Radic. Biol. Med. by Ramassamy (1999)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:55 a.m.)
Deposited	3 years, 7 months ago (Jan. 3, 2022, 6:13 p.m.)
Indexed	4 days, 8 hours ago (Aug. 23, 2025, 9:17 p.m.)
Issued	25 years, 2 months ago (June 1, 2000)
Published	25 years, 2 months ago (June 1, 2000)
Published Print	25 years, 2 months ago (June 1, 2000)

Funders 0

None

BibTeX

@article{Cuajungco_2000, title={Evidence that the β-Amyloid Plaques of Alzheimer’s Disease Represent the Redox-silencing and Entombment of Aβ by Zinc}, volume={275}, ISSN={0021-9258}, url={http://dx.doi.org/10.1074/jbc.c000165200}, DOI={10.1074/jbc.c000165200}, number={26}, journal={Journal of Biological Chemistry}, publisher={Elsevier BV}, author={Cuajungco, Math P. and Goldstein, Lee E. and Nunomura, Akihiko and Smith, Mark A. and Lim, James T. and Atwood, Craig S. and Huang, Xudong and Farrag, Yasser W. and Perry, George and Bush, Ashley I.}, year={2000}, month=jun, pages={19439–19442} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        24
      ]
    ],
    "date-time": "2025-08-24T01:17:13Z",
    "timestamp": 1755998233353
  },
  "reference-count": 31,
  "publisher": "Elsevier BV",
  "issue": "26",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2000,
            6,
            1
          ]
        ],
        "date-time": "2000-06-01T00:00:00Z",
        "timestamp": 959817600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2020,
            10,
            5
          ]
        ],
        "date-time": "2020-10-05T00:00:00Z",
        "timestamp": 1601856000000
      },
      "content-version": "vor",
      "delay-in-days": 7431,
      "URL": "http://creativecommons.org/licenses/by/4.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2000,
        6
      ]
    ]
  },
  "DOI": "10.1074/jbc.c000165200",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        26
      ]
    ],
    "date-time": "2002-07-26T14:55:13Z",
    "timestamp": 1027695313000
  },
  "page": "19439-19442",
  "source": "Crossref",
  "is-referenced-by-count": 323,
  "title": "Evidence that the \u03b2-Amyloid Plaques of Alzheimer's Disease Represent the Redox-silencing and Entombment of A\u03b2 by Zinc",
  "prefix": "10.1016",
  "volume": "275",
  "author": [
    {
      "given": "Math P.",
      "family": "Cuajungco",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Lee E.",
      "family": "Goldstein",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Akihiko",
      "family": "Nunomura",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Mark A.",
      "family": "Smith",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "James T.",
      "family": "Lim",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Craig S.",
      "family": "Atwood",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Xudong",
      "family": "Huang",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Yasser W.",
      "family": "Farrag",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "George",
      "family": "Perry",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Ashley I.",
      "family": "Bush",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1074/jbc.C000165200_bib1",
      "doi-asserted-by": "crossref",
      "first-page": "885",
      "DOI": "10.1016/S0006-291X(84)80190-4",
      "volume": "120",
      "author": "Glenner",
      "year": "1984",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1074/jbc.C000165200_bib2",
      "doi-asserted-by": "crossref",
      "first-page": "733",
      "DOI": "10.1038/325733a0",
      "volume": "325",
      "author": "Kang",
      "year": "1987",
      "journal-title": "Nature"
    },
    {
      "key": "10.1074/jbc.C000165200_bib3",
      "first-page": "309",
      "volume": "36",
      "author": "Atwood",
      "year": "1999",
      "journal-title": "Metal Ions Biol. Syst."
    },
    {
      "key": "10.1074/jbc.C000165200_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "2212",
      "DOI": "10.1046/j.1471-4159.1998.70052212.x",
      "volume": "70",
      "author": "Smith",
      "year": "1998",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1074/jbc.C000165200_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "37111",
      "DOI": "10.1074/jbc.274.52.37111",
      "volume": "274",
      "author": "Huang",
      "year": "1999",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.C000165200_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "7609",
      "DOI": "10.1021/bi990438f",
      "volume": "38",
      "author": "Huang",
      "year": "1999",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1074/jbc.C000165200_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "472",
      "DOI": "10.1097/00005072-198107000-00009",
      "volume": "40",
      "author": "Vaughan",
      "year": "1981",
      "journal-title": "J. Neuropathol. Exp. Neurol."
    },
    {
      "key": "10.1074/jbc.C000165200_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "47",
      "DOI": "10.1016/S0022-510X(98)00092-6",
      "volume": "158",
      "author": "Lovell",
      "year": "1998",
      "journal-title": "J. Neurol. Sci."
    },
    {
      "key": "10.1074/jbc.C000165200_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "594",
      "DOI": "10.1097/00005072-199311000-00006",
      "volume": "52",
      "author": "Hyman",
      "year": "1993",
      "journal-title": "J. Neuropathol. Exp. Neurol."
    },
    {
      "key": "10.1074/jbc.C000165200_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "860",
      "DOI": "10.1002/1531-8249(199912)46:6<860::AID-ANA8>3.0.CO;2-M",
      "volume": "46",
      "author": "McLean",
      "year": "1999",
      "journal-title": "Ann. Neurol."
    },
    {
      "key": "10.1074/jbc.C000165200_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "20631",
      "DOI": "10.1074/jbc.271.34.20631",
      "volume": "271",
      "author": "Roher",
      "year": "1996",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.C000165200_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "274",
      "DOI": "10.1016/S0006-8993(99)02096-X",
      "volume": "852",
      "author": "Suh",
      "year": "2000",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1074/jbc.C000165200_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1523/JNEUROSCI.19-01-00001.1999",
      "volume": "19",
      "author": "Lee",
      "year": "1999",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1074/jbc.C000165200_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "12152",
      "DOI": "10.1016/S0021-9258(17)32694-7",
      "volume": "269",
      "author": "Bush",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.C000165200_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "1464",
      "DOI": "10.1126/science.8073293",
      "volume": "265",
      "author": "Bush",
      "year": "1994",
      "journal-title": "Science"
    },
    {
      "key": "10.1074/jbc.C000165200_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "26464",
      "DOI": "10.1074/jbc.272.42.26464",
      "volume": "272",
      "author": "Huang",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.C000165200_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "23223",
      "DOI": "10.1074/jbc.274.33.23223",
      "volume": "274",
      "author": "Cherny",
      "year": "1999",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.C000165200_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "1959",
      "DOI": "10.1523/JNEUROSCI.19-06-01959.1999",
      "volume": "19",
      "author": "Nunomura",
      "year": "1999",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1074/jbc.C000165200_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "268",
      "DOI": "10.1016/0003-2697(91)90229-M",
      "volume": "194",
      "author": "Campbell",
      "year": "1991",
      "journal-title": "Anal. Biochem."
    },
    {
      "key": "10.1074/jbc.C000165200_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "2653",
      "DOI": "10.1523/JNEUROSCI.17-08-02653.1997",
      "volume": "17",
      "author": "Smith",
      "year": "1997",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1074/jbc.C000165200_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "88",
      "DOI": "10.1016/S0006-8993(99)01114-2",
      "volume": "823",
      "author": "Lovell",
      "year": "1999",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1074/jbc.C000165200_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "108",
      "DOI": "10.1016/0005-2736(94)90039-6",
      "volume": "1190",
      "author": "Huang",
      "year": "1994",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1074/jbc.C000165200_bib23",
      "unstructured": "Atwood, C. S., Scarpa, R. C., Huang, X., Moir, R. D., Jones, W. D., Fairlie, D. P., Tanzi, R. E., and Bush, A. I. (2000) J. Neurochem., in press"
    },
    {
      "key": "10.1074/jbc.C000165200_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "149",
      "DOI": "10.1006/exnr.1998.7009",
      "volume": "156",
      "author": "Penkowa",
      "year": "1999",
      "journal-title": "Exp. Neurol."
    },
    {
      "key": "10.1074/jbc.C000165200_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "3478",
      "DOI": "10.1073/pnas.95.7.3478",
      "volume": "95",
      "author": "Maret",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1074/jbc.C000165200_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "145",
      "DOI": "10.1016/S0074-7742(08)60279-2",
      "volume": "31",
      "author": "Frederickson",
      "year": "1989",
      "journal-title": "Int. Rev. Neurobiol."
    },
    {
      "key": "10.1074/jbc.C000165200_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "357",
      "DOI": "10.1038/1243",
      "volume": "19",
      "author": "Blacker",
      "year": "1998",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1074/jbc.C000165200_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "299",
      "DOI": "10.1046/j.1471-4159.1997.69010299.x",
      "volume": "69",
      "author": "Du",
      "year": "1997",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1074/jbc.C000165200_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "4595",
      "DOI": "10.1021/bi982437d",
      "volume": "38",
      "author": "Moir",
      "year": "1999",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1074/jbc.C000165200_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "55",
      "DOI": "10.1038/ng0996-55",
      "volume": "14",
      "author": "Miyata",
      "year": "1996",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1074/jbc.C000165200_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "544",
      "DOI": "10.1016/S0891-5849(99)00102-1",
      "volume": "27",
      "author": "Ramassamy",
      "year": "1999",
      "journal-title": "Free Radic. Biol. Med."
    }
  ],
  "container-title": "Journal of Biological Chemistry",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0021925819800042?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0021925819800042?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://syndication.highwire.org/content/doi/10.1074/jbc.C000165200",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2022,
        1,
        3
      ]
    ],
    "date-time": "2022-01-03T23:13:47Z",
    "timestamp": 1641251627000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0021925819800042"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2000,
        6
      ]
    ]
  },
  "references-count": 31,
  "journal-issue": {
    "issue": "26",
    "published-print": {
      "date-parts": [
        [
          2000,
          6
        ]
      ]
    }
  },
  "alternative-id": [
    "S0021925819800042"
  ],
  "URL": "http://dx.doi.org/10.1074/jbc.C000165200",
  "relation": {},
  "ISSN": [
    "0021-9258"
  ],
  "subject": [],
  "container-title-short": "Journal of Biological Chemistry",
  "published": {
    "date-parts": [
      [
        2000,
        6
      ]
    ]
  }
}