DOI: 10.1074/jbc.274.27.19465. Isolation and Biochemical Characterization of the Human Dkk-1 Homologue, a Novel Inhibitor of Mammalian Wnt Signaling

Isolation and Biochemical Characterization of the Human Dkk-1 Homologue, a Novel Inhibitor of Mammalian Wnt Signaling

10.1074/jbc.274.27.19465

Crossref journal-article

Elsevier BV

Journal of Biological Chemistry (78)

Bibliography

Fedi, P., Bafico, A., Soria, A. N., Burgess, W. H., Miki, T., Bottaro, D. P., Kraus, M. H., & Aaronson, S. A. (1999). Isolation and Biochemical Characterization of the Human Dkk-1 Homologue, a Novel Inhibitor of Mammalian Wnt Signaling. Journal of Biological Chemistry, 274(27), 19465â19472.

Authors 8

Paolo Fedi (first)
Anna Bafico (additional)
Almudena Nieto Soria (additional)
Wilson H. Burgess (additional)
Toru Miki (additional)
Donald P. Bottaro (additional)
Matthias H. Kraus (additional)
Stuart A. Aaronson (additional)

References 38 Referenced 224

10.1101/gad.11.24.3286 / Genes Dev. by Cadigan (1997)
10.1016/0092-8674(92)90630-U / Cell by Nusse (1992)
10.1038/382225a0 / Nature by Bhanot (1996)
10.1016/0955-0674(95)80104-9 / Curr. Opin. Cell Biol. by Gumbiner (1995)
10.1101/gad.10.20.2527 / Genes Dev. by Miller (1996)
10.1073/pnas.95.6.3020 / Proc. Natl. Acad. Sci. U. S. A. by Sakanaka (1998)
10.1038/382638a0 / Nature by Behrens (1996)
{'key': '10.1074/jbc.274.27.19465_bib8', 'first-page': '4413', 'volume': '52', 'author': 'Lin', 'year': '1992', 'journal-title': 'Cancer Res.'} / Cancer Res. by Lin (1992)
10.1016/0092-8674(86)90699-9 / Cell by Brown (1986)
{'key': '10.1074/jbc.274.27.19465_bib10', 'first-page': '6278', 'volume': '14', 'author': 'Wong', 'year': '1994', 'journal-title': 'Mol. Cell. Biol.'} / Mol. Cell. Biol. by Wong (1994)
10.1038/sj.onc.1201797 / Oncogene by Bafico (1998)
10.1128/MCB.18.5.2474 / Mol. Cell. Biol. by Young (1998)
10.1126/science.275.5307.1787 / Science by Morin (1997)
10.1126/science.275.5307.1790 / Science by Rubinfeld (1997)
10.1073/pnas.95.15.8847 / Proc. Natl. Acad. Sci. U. S. A. by de La Coste (1998)
10.1073/pnas.94.13.6770 / Proc. Natl. Acad. Sci. U. S. A. by Finch (1997)
10.1126/science.275.5306.1652 / Science by He (1997)
10.1016/S0092-8674(00)81921-2 / Cell by Leyns (1997)
10.1016/S0092-8674(00)81922-4 / Cell by Wang (1997)
10.1038/382595a0 / Nature by Bouwmeester (1996)
10.1038/17820 / Nature by Piccolo (1999)
10.1038/34848 / Nature by Glinka (1998)
{'key': '10.1074/jbc.274.27.19465_bib23', 'first-page': '1813', 'volume': '10', 'author': 'Alimandi', 'year': '1995', 'journal-title': 'Oncogene'} / Oncogene by Alimandi (1995)
10.1073/pnas.88.12.5167 / Proc. Natl. Acad. Sci. U. S. A. by Miki (1991)
10.1016/0076-6879(95)54015-6 / Methods Enzymol. by Miki (1995)
10.1016/0076-6879(91)00170-2 / Methods Enzymol. by Kraus (1991)
10.1073/pnas.90.7.2900 / Proc. Natl. Acad. Sci. U. S. A. by Kraus (1993)
10.1126/science.2475908 / Science by Finch (1989)
{'key': '10.1074/jbc.274.27.19465_bib29', 'first-page': '492', 'volume': '14', 'author': 'Fedi', 'year': '1994', 'journal-title': 'Mol. Cell. Biol.'} / Mol. Cell. Biol. by Fedi (1994)
10.1083/jcb.108.2.229 / J. Cell Biol. by Kozak (1989)
10.1016/0022-2836(82)90515-0 / J. Mol. Biol. by Kyte (1982)
10.1016/S0960-9822(98)70309-4 / Curr. Biol. by Aravind (1998)
10.1038/39092 / Nature by Glinka (1997)
10.1128/MCB.15.5.2625 / Mol. Cell. Biol. by Du (1995)
10.1083/jcb.133.5.1123 / J. Cell Biol. by Torres (1996)
{'key': '10.1074/jbc.274.27.19465_bib36', 'first-page': '2597', 'volume': '9', 'author': 'Bradbury', 'year': '1994', 'journal-title': 'Oncogene'} / Oncogene by Bradbury (1994)
10.1073/pnas.94.21.11196 / Proc. Natl. Acad. Sci. U. S. A. by Lin (1997)
10.1038/18899 / Nature by Hsieh (1999)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:55 a.m.)
Deposited	3 years, 8 months ago (Jan. 3, 2022, 3:24 p.m.)
Indexed	3 months ago (June 3, 2025, 4:29 p.m.)
Issued	26 years, 2 months ago (July 1, 1999)
Published	26 years, 2 months ago (July 1, 1999)
Published Print	26 years, 2 months ago (July 1, 1999)

Funders 0

None

BibTeX

@article{Fedi_1999, title={Isolation and Biochemical Characterization of the Human Dkk-1 Homologue, a Novel Inhibitor of Mammalian Wnt Signaling}, volume={274}, ISSN={0021-9258}, url={http://dx.doi.org/10.1074/jbc.274.27.19465}, DOI={10.1074/jbc.274.27.19465}, number={27}, journal={Journal of Biological Chemistry}, publisher={Elsevier BV}, author={Fedi, Paolo and Bafico, Anna and Soria, Almudena Nieto and Burgess, Wilson H. and Miki, Toru and Bottaro, Donald P. and Kraus, Matthias H. and Aaronson, Stuart A.}, year={1999}, month=jul, pages={19465–19472} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        6,
        3
      ]
    ],
    "date-time": "2025-06-03T20:29:19Z",
    "timestamp": 1748982559840
  },
  "reference-count": 38,
  "publisher": "Elsevier BV",
  "issue": "27",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1999,
            7,
            1
          ]
        ],
        "date-time": "1999-07-01T00:00:00Z",
        "timestamp": 930787200000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2020,
            10,
            1
          ]
        ],
        "date-time": "2020-10-01T00:00:00Z",
        "timestamp": 1601510400000
      },
      "content-version": "vor",
      "delay-in-days": 7763,
      "URL": "http://creativecommons.org/licenses/by/4.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1999,
        7
      ]
    ]
  },
  "DOI": "10.1074/jbc.274.27.19465",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        26
      ]
    ],
    "date-time": "2002-07-26T14:55:13Z",
    "timestamp": 1027695313000
  },
  "page": "19465-19472",
  "source": "Crossref",
  "is-referenced-by-count": 224,
  "title": "Isolation and Biochemical Characterization of the Human Dkk-1 Homologue, a Novel Inhibitor of Mammalian Wnt Signaling",
  "prefix": "10.1016",
  "volume": "274",
  "author": [
    {
      "given": "Paolo",
      "family": "Fedi",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Anna",
      "family": "Bafico",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Almudena Nieto",
      "family": "Soria",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Wilson H.",
      "family": "Burgess",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Toru",
      "family": "Miki",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Donald P.",
      "family": "Bottaro",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Matthias H.",
      "family": "Kraus",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Stuart A.",
      "family": "Aaronson",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1074/jbc.274.27.19465_bib1",
      "doi-asserted-by": "crossref",
      "first-page": "3286",
      "DOI": "10.1101/gad.11.24.3286",
      "volume": "11",
      "author": "Cadigan",
      "year": "1997",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib2",
      "doi-asserted-by": "crossref",
      "first-page": "1073",
      "DOI": "10.1016/0092-8674(92)90630-U",
      "volume": "69",
      "author": "Nusse",
      "year": "1992",
      "journal-title": "Cell"
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "225",
      "DOI": "10.1038/382225a0",
      "volume": "382",
      "author": "Bhanot",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "634",
      "DOI": "10.1016/0955-0674(95)80104-9",
      "volume": "7",
      "author": "Gumbiner",
      "year": "1995",
      "journal-title": "Curr. Opin. Cell Biol."
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "2527",
      "DOI": "10.1101/gad.10.20.2527",
      "volume": "10",
      "author": "Miller",
      "year": "1996",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "3020",
      "DOI": "10.1073/pnas.95.6.3020",
      "volume": "95",
      "author": "Sakanaka",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "638",
      "DOI": "10.1038/382638a0",
      "volume": "382",
      "author": "Behrens",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib8",
      "first-page": "4413",
      "volume": "52",
      "author": "Lin",
      "year": "1992",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "1001",
      "DOI": "10.1016/0092-8674(86)90699-9",
      "volume": "46",
      "author": "Brown",
      "year": "1986",
      "journal-title": "Cell"
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib10",
      "first-page": "6278",
      "volume": "14",
      "author": "Wong",
      "year": "1994",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "2819",
      "DOI": "10.1038/sj.onc.1201797",
      "volume": "16",
      "author": "Bafico",
      "year": "1998",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "2474",
      "DOI": "10.1128/MCB.18.5.2474",
      "volume": "18",
      "author": "Young",
      "year": "1998",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "1787",
      "DOI": "10.1126/science.275.5307.1787",
      "volume": "275",
      "author": "Morin",
      "year": "1997",
      "journal-title": "Science"
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "1790",
      "DOI": "10.1126/science.275.5307.1790",
      "volume": "275",
      "author": "Rubinfeld",
      "year": "1997",
      "journal-title": "Science"
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "8847",
      "DOI": "10.1073/pnas.95.15.8847",
      "volume": "95",
      "author": "de La Coste",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "6770",
      "DOI": "10.1073/pnas.94.13.6770",
      "volume": "94",
      "author": "Finch",
      "year": "1997",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "1652",
      "DOI": "10.1126/science.275.5306.1652",
      "volume": "275",
      "author": "He",
      "year": "1997",
      "journal-title": "Science"
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "747",
      "DOI": "10.1016/S0092-8674(00)81921-2",
      "volume": "88",
      "author": "Leyns",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "757",
      "DOI": "10.1016/S0092-8674(00)81922-4",
      "volume": "88",
      "author": "Wang",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "595",
      "DOI": "10.1038/382595a0",
      "volume": "382",
      "author": "Bouwmeester",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "707",
      "DOI": "10.1038/17820",
      "volume": "397",
      "author": "Piccolo",
      "year": "1999",
      "journal-title": "Nature"
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "357",
      "DOI": "10.1038/34848",
      "volume": "391",
      "author": "Glinka",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib23",
      "first-page": "1813",
      "volume": "10",
      "author": "Alimandi",
      "year": "1995",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "5167",
      "DOI": "10.1073/pnas.88.12.5167",
      "volume": "88",
      "author": "Miki",
      "year": "1991",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "196",
      "DOI": "10.1016/0076-6879(95)54015-6",
      "volume": "254",
      "author": "Miki",
      "year": "1995",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "546",
      "DOI": "10.1016/0076-6879(91)00170-2",
      "volume": "200",
      "author": "Kraus",
      "year": "1991",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "2900",
      "DOI": "10.1073/pnas.90.7.2900",
      "volume": "90",
      "author": "Kraus",
      "year": "1993",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "752",
      "DOI": "10.1126/science.2475908",
      "volume": "245",
      "author": "Finch",
      "year": "1989",
      "journal-title": "Science"
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib29",
      "first-page": "492",
      "volume": "14",
      "author": "Fedi",
      "year": "1994",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "229",
      "DOI": "10.1083/jcb.108.2.229",
      "volume": "108",
      "author": "Kozak",
      "year": "1989",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "105",
      "DOI": "10.1016/0022-2836(82)90515-0",
      "volume": "157",
      "author": "Kyte",
      "year": "1982",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "R477",
      "DOI": "10.1016/S0960-9822(98)70309-4",
      "volume": "8",
      "author": "Aravind",
      "year": "1998",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "517",
      "DOI": "10.1038/39092",
      "volume": "389",
      "author": "Glinka",
      "year": "1997",
      "journal-title": "Nature"
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "2625",
      "DOI": "10.1128/MCB.15.5.2625",
      "volume": "15",
      "author": "Du",
      "year": "1995",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "1123",
      "DOI": "10.1083/jcb.133.5.1123",
      "volume": "133",
      "author": "Torres",
      "year": "1996",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib36",
      "first-page": "2597",
      "volume": "9",
      "author": "Bradbury",
      "year": "1994",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "11196",
      "DOI": "10.1073/pnas.94.21.11196",
      "volume": "94",
      "author": "Lin",
      "year": "1997",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1074/jbc.274.27.19465_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "431",
      "DOI": "10.1038/18899",
      "volume": "398",
      "author": "Hsieh",
      "year": "1999",
      "journal-title": "Nature"
    }
  ],
  "container-title": "Journal of Biological Chemistry",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0021925819741751?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0021925819741751?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://syndication.highwire.org/content/doi/10.1074/jbc.274.27.19465",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2022,
        1,
        3
      ]
    ],
    "date-time": "2022-01-03T20:24:30Z",
    "timestamp": 1641241470000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0021925819741751"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1999,
        7
      ]
    ]
  },
  "references-count": 38,
  "journal-issue": {
    "issue": "27",
    "published-print": {
      "date-parts": [
        [
          1999,
          7
        ]
      ]
    }
  },
  "alternative-id": [
    "S0021925819741751"
  ],
  "URL": "http://dx.doi.org/10.1074/jbc.274.27.19465",
  "relation": {},
  "ISSN": [
    "0021-9258"
  ],
  "subject": [],
  "container-title-short": "Journal of Biological Chemistry",
  "published": {
    "date-parts": [
      [
        1999,
        7
      ]
    ]
  }
}