DOI: 10.1074/jbc.271.40.24907. Phosphatidylinositol 4,5-Bisphosphate (PIP2)-enhanced G Protein-coupled Receptor Kinase (GRK) Activity: LOCATION, STRUCTURE, AND REGULATION OF THE PIP2 BINDING SITE DISTINGUISHES THE GRK SUBFAMILIES

Phosphatidylinositol 4,5-Bisphosphate (PIP2)-enhanced G Protein-coupled Receptor Kinase (GRK) Activity: LOCATION, STRUCTURE, AND REGULATION OF THE PIP2 BINDING SITE DISTINGUISHES THE GRK SUBFAMILIES

10.1074/jbc.271.40.24907

Crossref journal-article

Elsevier BV

Journal of Biological Chemistry (78)

Bibliography

Pitcher, J. A., Fredericks, Z. L., Stone, W. C., Premont, R. T., Stoffel, R. H., Koch, W. J., & Lefkowitz, R. J. (1996). Phosphatidylinositol 4,5-Bisphosphate (PIP2)-enhanced G Protein-coupled Receptor Kinase (GRK) Activity: LOCATION, STRUCTURE, AND REGULATION OF THE PIP2 BINDING SITE DISTINGUISHES THE GRK SUBFAMILIES. Journal of Biological Chemistry, 271(40), 24907â24913.

Authors 7

Julie A. Pitcher (first)
Zoey L. Fredericks (additional)
W. Carl Stone (additional)
Richard T. Premont (additional)
Robert H. Stoffel (additional)
Walter J. Koch (additional)
Robert J. Lefkowitz (additional)

References 35 Referenced 149

{'key': '10.1074/jbc.271.40.24907_bib1', 'first-page': '319', 'volume': '51', 'author': 'Freedman', 'year': '1996', 'journal-title': '1995 Recent Prog. Horm. Res. Proc.'} / 1995 Recent Prog. Horm. Res. Proc. by Freedman (1996)
10.1016/S0021-9258(20)80439-6 / J. Biol. Chem. by Inglese (1993)
10.1096/fasebj.9.2.7781920 / FASEB J. by Premont (1995)
10.1021/bi00614a006 / Biochemistry by Kuhn (1978)
10.1016/S0021-9258(19)50511-7 / J. Biol. Chem. by Chuang (1992)
10.1016/S0021-9258(18)45960-1 / J. Biol. Chem. by Inglese (1992)
10.1038/359147a0 / Nature by Inglese (1992)
10.1016/0092-8674(93)90244-K / Cell by Mayer (1993)
10.1038/363309b0 / Nature by Haslam (1993)
10.1038/369672a0 / Nature by Yoon (1994)
10.1038/369675a0 / Nature by Macias (1994)
10.1016/0092-8674(94)90190-2 / Cell by Ferguson (1994)
10.1038/nsb1194-782 / Nature Struc. Biol. by Timm (1994)
10.1074/jbc.270.20.11707 / J. Biol. Chem. by Pitcher (1995)
10.1016/S0021-9258(18)46852-4 / J. Biol. Chem. by Stoffel (1994)
10.1074/jbc.271.11.6403 / J. Biol. Chem. by Premont (1996)
10.1016/S0021-9258(17)34046-2 / J. Biol. Chem. by Kunapuli (1994)
{'key': '10.1074/jbc.271.40.24907_bib18', 'first-page': '39', 'volume': '3', 'author': 'Kim', 'year': '1993', 'journal-title': 'Receptor'} / Receptor by Kim (1993)
10.1016/S0021-9258(17)37451-3 / J. Biol. Chem. by Premont (1994)
10.1021/bi00428a029 / Biochemistry by Casey (1989)
{'key': '10.1074/jbc.271.40.24907_bib21', 'first-page': '687', 'volume': '152', 'author': 'Cullen', 'year': '1987', 'journal-title': 'Methods Enzymol.'} / Methods Enzymol. by Cullen (1987)
10.1021/bi00708a031 / Biochemistry by Papermaster (1974)
10.1021/bi00374a001 / Biochemistry by Eaton (1986)
10.1021/bi00315a002 / Biochemistry by Benovic (1984)
10.1038/306562a0 / Nature by Cerione (1983)
10.1021/bi00235a002 / Biochemistry by Onorato (1991)
10.1016/S0021-9258(19)36546-9 / J. Biol. Chem. by Benovic (1993)
10.1074/jbc.270.11.5742 / J. Biol. Chem. by DebBurman (1995)
10.1074/jbc.270.36.21346 / J. Biol. Chem. by Onorato (1995)
10.1016/S0021-9258(18)42851-7 / J. Biol. Chem. by Kurland (1992)
10.1016/S0021-9258(18)42086-8 / J. Biol. Chem. by Yu (1992)
10.1016/1074-5521(95)90276-7 / Chem. Biol. by Janmey (1995)
10.1016/S0021-9258(18)52273-0 / J. Biol. Chem. by Brockman (1991)
10.1016/S0021-9258(17)42264-2 / J. Biol. Chem. by Garcia-Higuera (1994)
10.1074/jbc.271.2.985 / J. Biol. Chem. by Murga (1996)

Dates

Type	When
Created	23 years ago (July 26, 2002, 10:51 a.m.)
Deposited	3 years, 7 months ago (Dec. 31, 2021, 8:30 p.m.)
Indexed	4 weeks, 1 day ago (July 27, 2025, 3:32 a.m.)
Issued	28 years, 10 months ago (Oct. 1, 1996)
Published	28 years, 10 months ago (Oct. 1, 1996)
Published Print	28 years, 10 months ago (Oct. 1, 1996)

Funders 0

None

BibTeX

@article{Pitcher_1996, title={Phosphatidylinositol 4,5-Bisphosphate (PIP2)-enhanced G Protein-coupled Receptor Kinase (GRK) Activity: LOCATION, STRUCTURE, AND REGULATION OF THE PIP2 BINDING SITE DISTINGUISHES THE GRK SUBFAMILIES}, volume={271}, ISSN={0021-9258}, url={http://dx.doi.org/10.1074/jbc.271.40.24907}, DOI={10.1074/jbc.271.40.24907}, number={40}, journal={Journal of Biological Chemistry}, publisher={Elsevier BV}, author={Pitcher, Julie A. and Fredericks, Zoey L. and Stone, W. Carl and Premont, Richard T. and Stoffel, Robert H. and Koch, Walter J. and Lefkowitz, Robert J.}, year={1996}, month=oct, pages={24907–24913} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        27
      ]
    ],
    "date-time": "2025-07-27T07:32:04Z",
    "timestamp": 1753601524262
  },
  "reference-count": 35,
  "publisher": "Elsevier BV",
  "issue": "40",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1996,
            10,
            1
          ]
        ],
        "date-time": "1996-10-01T00:00:00Z",
        "timestamp": 844128000000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2020,
            10,
            9
          ]
        ],
        "date-time": "2020-10-09T00:00:00Z",
        "timestamp": 1602201600000
      },
      "content-version": "vor",
      "delay-in-days": 8774,
      "URL": "http://creativecommons.org/licenses/by/4.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1996,
        10
      ]
    ]
  },
  "DOI": "10.1074/jbc.271.40.24907",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        26
      ]
    ],
    "date-time": "2002-07-26T14:51:35Z",
    "timestamp": 1027695095000
  },
  "page": "24907-24913",
  "source": "Crossref",
  "is-referenced-by-count": 149,
  "title": "Phosphatidylinositol 4,5-Bisphosphate (PIP2)-enhanced G Protein-coupled Receptor Kinase (GRK) Activity: LOCATION, STRUCTURE, AND REGULATION OF THE PIP2 BINDING SITE DISTINGUISHES THE GRK SUBFAMILIES",
  "prefix": "10.1016",
  "volume": "271",
  "author": [
    {
      "given": "Julie A.",
      "family": "Pitcher",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Zoey L.",
      "family": "Fredericks",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "W. Carl",
      "family": "Stone",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Richard T.",
      "family": "Premont",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Robert H.",
      "family": "Stoffel",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Walter J.",
      "family": "Koch",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Robert J.",
      "family": "Lefkowitz",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1074/jbc.271.40.24907_bib1",
      "first-page": "319",
      "volume": "51",
      "author": "Freedman",
      "year": "1996",
      "journal-title": "1995 Recent Prog. Horm. Res. Proc."
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib2",
      "doi-asserted-by": "crossref",
      "first-page": "23735",
      "DOI": "10.1016/S0021-9258(20)80439-6",
      "volume": "268",
      "author": "Inglese",
      "year": "1993",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "175",
      "DOI": "10.1096/fasebj.9.2.7781920",
      "volume": "9",
      "author": "Premont",
      "year": "1995",
      "journal-title": "FASEB J."
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "4389",
      "DOI": "10.1021/bi00614a006",
      "volume": "21",
      "author": "Kuhn",
      "year": "1978",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "6886",
      "DOI": "10.1016/S0021-9258(19)50511-7",
      "volume": "267",
      "author": "Chuang",
      "year": "1992",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "1422",
      "DOI": "10.1016/S0021-9258(18)45960-1",
      "volume": "267",
      "author": "Inglese",
      "year": "1992",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "147",
      "DOI": "10.1038/359147a0",
      "volume": "359",
      "author": "Inglese",
      "year": "1992",
      "journal-title": "Nature"
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "629",
      "DOI": "10.1016/0092-8674(93)90244-K",
      "volume": "73",
      "author": "Mayer",
      "year": "1993",
      "journal-title": "Cell"
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "310",
      "DOI": "10.1038/363309b0",
      "volume": "363",
      "author": "Haslam",
      "year": "1993",
      "journal-title": "Nature"
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "672",
      "DOI": "10.1038/369672a0",
      "volume": "369",
      "author": "Yoon",
      "year": "1994",
      "journal-title": "Nature"
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "675",
      "DOI": "10.1038/369675a0",
      "volume": "369",
      "author": "Macias",
      "year": "1994",
      "journal-title": "Nature"
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "199",
      "DOI": "10.1016/0092-8674(94)90190-2",
      "volume": "79",
      "author": "Ferguson",
      "year": "1994",
      "journal-title": "Cell"
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "782",
      "DOI": "10.1038/nsb1194-782",
      "volume": "1",
      "author": "Timm",
      "year": "1994",
      "journal-title": "Nature Struc. Biol."
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "11707",
      "DOI": "10.1074/jbc.270.20.11707",
      "volume": "270",
      "author": "Pitcher",
      "year": "1995",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "27791",
      "DOI": "10.1016/S0021-9258(18)46852-4",
      "volume": "269",
      "author": "Stoffel",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "6403",
      "DOI": "10.1074/jbc.271.11.6403",
      "volume": "271",
      "author": "Premont",
      "year": "1996",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "10209",
      "DOI": "10.1016/S0021-9258(17)34046-2",
      "volume": "269",
      "author": "Kunapuli",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib18",
      "first-page": "39",
      "volume": "3",
      "author": "Kim",
      "year": "1993",
      "journal-title": "Receptor"
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "6832",
      "DOI": "10.1016/S0021-9258(17)37451-3",
      "volume": "269",
      "author": "Premont",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "611",
      "DOI": "10.1021/bi00428a029",
      "volume": "28",
      "author": "Casey",
      "year": "1989",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib21",
      "first-page": "687",
      "volume": "152",
      "author": "Cullen",
      "year": "1987",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "2438",
      "DOI": "10.1021/bi00708a031",
      "volume": "13",
      "author": "Papermaster",
      "year": "1974",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "8343",
      "DOI": "10.1021/bi00374a001",
      "volume": "25",
      "author": "Eaton",
      "year": "1986",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "4510",
      "DOI": "10.1021/bi00315a002",
      "volume": "23",
      "author": "Benovic",
      "year": "1984",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "562",
      "DOI": "10.1038/306562a0",
      "volume": "306",
      "author": "Cerione",
      "year": "1983",
      "journal-title": "Nature"
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "5118",
      "DOI": "10.1021/bi00235a002",
      "volume": "30",
      "author": "Onorato",
      "year": "1991",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "19521",
      "DOI": "10.1016/S0021-9258(19)36546-9",
      "volume": "268",
      "author": "Benovic",
      "year": "1993",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "5742",
      "DOI": "10.1074/jbc.270.11.5742",
      "volume": "270",
      "author": "DebBurman",
      "year": "1995",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "21346",
      "DOI": "10.1074/jbc.270.36.21346",
      "volume": "270",
      "author": "Onorato",
      "year": "1995",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "4416",
      "DOI": "10.1016/S0021-9258(18)42851-7",
      "volume": "267",
      "author": "Kurland",
      "year": "1992",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "14616",
      "DOI": "10.1016/S0021-9258(18)42086-8",
      "volume": "267",
      "author": "Yu",
      "year": "1992",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "61",
      "DOI": "10.1016/1074-5521(95)90276-7",
      "volume": "2",
      "author": "Janmey",
      "year": "1995",
      "journal-title": "Chem. Biol."
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "2508",
      "DOI": "10.1016/S0021-9258(18)52273-0",
      "volume": "266",
      "author": "Brockman",
      "year": "1991",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "1348",
      "DOI": "10.1016/S0021-9258(17)42264-2",
      "volume": "269",
      "author": "Garcia-Higuera",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1074/jbc.271.40.24907_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "985",
      "DOI": "10.1074/jbc.271.2.985",
      "volume": "271",
      "author": "Murga",
      "year": "1996",
      "journal-title": "J. Biol. Chem."
    }
  ],
  "container-title": "Journal of Biological Chemistry",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0021925818400920?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0021925818400920?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://syndication.highwire.org/content/doi/10.1074/jbc.271.40.24907",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2022,
        1,
        1
      ]
    ],
    "date-time": "2022-01-01T01:30:52Z",
    "timestamp": 1641000652000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0021925818400920"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1996,
        10
      ]
    ]
  },
  "references-count": 35,
  "journal-issue": {
    "issue": "40",
    "published-print": {
      "date-parts": [
        [
          1996,
          10
        ]
      ]
    }
  },
  "alternative-id": [
    "S0021925818400920"
  ],
  "URL": "http://dx.doi.org/10.1074/jbc.271.40.24907",
  "relation": {},
  "ISSN": [
    "0021-9258"
  ],
  "subject": [],
  "container-title-short": "Journal of Biological Chemistry",
  "published": {
    "date-parts": [
      [
        1996,
        10
      ]
    ]
  }
}