DOI: 10.1074/jbc.271.26.15810. A Single Amino Acid Difference between Cyclooxygenase-1 (COX-1) and −2 (COX-2) Reverses the Selectivity of COX-2 Specific Inhibitors

A Single Amino Acid Difference between Cyclooxygenase-1 (COX-1) and −2 (COX-2) Reverses the Selectivity of COX-2 Specific Inhibitors

10.1074/jbc.271.26.15810

Crossref journal-article

Elsevier BV

Journal of Biological Chemistry (78)

Bibliography

Gierse, J. K., McDonald, J. J., Hauser, S. D., Rangwala, S. H., Koboldt, C. M., & Seibert, K. (1996). A Single Amino Acid Difference between Cyclooxygenase-1 (COX-1) and â2 (COX-2) Reverses the Selectivity of COX-2 Specific Inhibitors. Journal of Biological Chemistry, 271(26), 15810â15814.

Authors 6

James K. Gierse (first)
Joseph J. McDonald (additional)
Scott D. Hauser (additional)
Shaukat H. Rangwala (additional)
Carol M. Koboldt (additional)
Karen Seibert (additional)

References 25 Referenced 324

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10.1016/S0021-9258(18)98774-0 / J. Biol. Chem. by Kujubu (1991)
10.1073/pnas.88.7.2692 / Proc. Natl. Acad. Sci. U. S. A. by Xie (1991)
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{'key': '10.1074/jbc.271.26.15810_bib12', 'first-page': '6971', 'volume': '87', 'author': 'Seboldt', 'year': '1990', 'journal-title': 'Proc. Natl. Acad. Sci. U. S. A.'} / Proc. Natl. Acad. Sci. U. S. A. by Seboldt (1990)
10.1016/S0021-9258(18)53294-4 / J Biol. Chem. by Meade (1993)
{'key': '10.1074/jbc.271.26.15810_bib14', 'first-page': '245', 'volume': '45', 'author': "O'Neill", 'year': '1994', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. by O'Neill (1994)
{'key': '10.1074/jbc.271.26.15810_bib15', 'series-title': 'The Pharmacological Basis of Therapeutics', 'first-page': '1431', 'author': 'Haynes', 'year': '1990'} / The Pharmacological Basis of Therapeutics by Haynes (1990)
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{'key': '10.1074/jbc.271.26.15810_bib20', 'first-page': '443', 'volume': '182', 'author': 'Takahashi', 'year': '1992', 'journal-title': 'Biochem. Biophys. Res. Commun.'} / Biochem. Biophys. Res. Commun. by Takahashi (1992)
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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:52 a.m.)
Deposited	3 years, 7 months ago (Dec. 31, 2021, 4:17 p.m.)
Indexed	1 month ago (July 27, 2025, 3:20 a.m.)
Issued	29 years, 2 months ago (June 1, 1996)
Published	29 years, 2 months ago (June 1, 1996)
Published Print	29 years, 2 months ago (June 1, 1996)

Funders 0

None

BibTeX

@article{Gierse_1996, title={A Single Amino Acid Difference between Cyclooxygenase-1 (COX-1) and −2 (COX-2) Reverses the Selectivity of COX-2 Specific Inhibitors}, volume={271}, ISSN={0021-9258}, url={http://dx.doi.org/10.1074/jbc.271.26.15810}, DOI={10.1074/jbc.271.26.15810}, number={26}, journal={Journal of Biological Chemistry}, publisher={Elsevier BV}, author={Gierse, James K. and McDonald, Joseph J. and Hauser, Scott D. and Rangwala, Shaukat H. and Koboldt, Carol M. and Seibert, Karen}, year={1996}, month=jun, pages={15810–15814} }

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