DOI: 10.1073/pnas.98.4.2005. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice

Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice

10.1073/pnas.98.4.2005

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Adipocyte complement-related protein (30 kDa) (Acrp30), a secreted protein of unknown function, is exclusively expressed in differentiated adipocytes; its mRNA is decreased in obese humans and mice. Here we describe novel pharmacological properties of the protease-generated globular head domain of Acrp30 (gAcrp30). Acute treatment of mice with gAcrp30 significantly decreased the elevated levels of plasma free fatty acids caused either by administration of a high fat test meal or by i.v. injection of Intralipid. This effect of gAcrp30 was caused, at least in part, by an acute increase in fatty acid oxidation by muscle. As a result, daily administration of a very low dose of gAcrp30 to mice consuming a high-fat/sucrose diet caused profound and sustainable weight reduction without affecting food intake. Thus, gAcrp30 is a novel pharmacological compound that controls energy homeostasis and exerts its effect primarily at the peripheral level.

Bibliography

Fruebis, J., Tsao, T.-S., Javorschi, S., Ebbets-Reed, D., Erickson, M. R. S., Yen, F. T., Bihain, B. E., & Lodish, H. F. (2001). Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proceedings of the National Academy of Sciences, 98(4), 2005â2010.

Authors 8

Joachim Fruebis (first)
Tsu-Shuen Tsao (additional)
Sandrine Javorschi (additional)
Dana Ebbets-Reed (additional)
Mary Ruth S. Erickson (additional)
Frances T. Yen (additional)
Bernard E. Bihain (additional)
Harvey F. Lodish (additional)

References 23 Referenced 1,251

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N Takamatsu, K Ohba, J Kondo, N Kondo, T Shiba Mol Cell Biol 13, 1516–1521 (1993). / Mol Cell Biol by Takamatsu N (1993)
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Dates

Type	When
Created	13 years, 1 month ago (July 26, 2012, 7:12 p.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 5:40 p.m.)
Indexed	1 week ago (Aug. 27, 2025, 11:46 a.m.)
Issued	24 years, 6 months ago (Feb. 6, 2001)
Published	24 years, 6 months ago (Feb. 6, 2001)
Published Online	24 years, 6 months ago (Feb. 6, 2001)
Published Print	24 years, 6 months ago (Feb. 13, 2001)

Funders 0

None

BibTeX

@article{Fruebis_2001, title={Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice}, volume={98}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.98.4.2005}, DOI={10.1073/pnas.98.4.2005}, number={4}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Fruebis, Joachim and Tsao, Tsu-Shuen and Javorschi, Sandrine and Ebbets-Reed, Dana and Erickson, Mary Ruth S. and Yen, Frances T. and Bihain, Bernard E. and Lodish, Harvey F.}, year={2001}, month=feb, pages={2005–2010} }

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