DOI: 10.1073/pnas.98.4.1519. The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex

The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex

10.1073/pnas.98.4.1519

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The E2F transcription factors play a key role in the regulation of cellular proliferation and terminal differentiation. E2F6 is the most recently identified and the least well understood member of the E2F family. It is only distantly related to the other E2Fs and lacks the sequences responsible for both transactivation and binding to the retinoblastoma protein. Consistent with this finding, E2F6 can behave as a dominant negative inhibitor of the other E2F family members. In this study, we continue to investigate the possible role(s) of E2F6 in vivo . We report the isolation of RYBP, a recently identified member of the mammalian polycomb complex, as an E2F6-interacting protein. Mapping studies indicate that RYBP binds within the known “repression domain” of E2F6. Moreover, we demonstrate that endogenous E2F6 and polycomb group proteins, including RYBP, Ring1, MEL-18, mph1, and the oncoprotein Bmi1, associate with one another. These findings suggest that the biological properties of E2F6 are mediated through its ability to recruit the polycomb transcriptional repressor complex.

Bibliography

Trimarchi, J. M., Fairchild, B., Wen, J., & Lees, J. A. (2001). The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex. Proceedings of the National Academy of Sciences, 98(4), 1519â1524.

Authors 4

Jeffrey M. Trimarchi (first)
Brian Fairchild (additional)
Jessica Wen (additional)
Jacqueline A. Lees (additional)

References 48 Referenced 175

Dates

Type	When
Created	13 years, 1 month ago (July 26, 2012, 7:12 p.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 5:36 p.m.)
Indexed	3 weeks, 4 days ago (Aug. 6, 2025, 9:14 a.m.)
Issued	24 years, 7 months ago (Jan. 30, 2001)
Published	24 years, 7 months ago (Jan. 30, 2001)
Published Online	24 years, 7 months ago (Jan. 30, 2001)
Published Print	24 years, 6 months ago (Feb. 13, 2001)

Funders 0

None

BibTeX

@article{Trimarchi_2001, title={The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex}, volume={98}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.98.4.1519}, DOI={10.1073/pnas.98.4.1519}, number={4}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Trimarchi, Jeffrey M. and Fairchild, Brian and Wen, Jessica and Lees, Jacqueline A.}, year={2001}, month=jan, pages={1519–1524} }

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