DOI: 10.1073/pnas.97.9.4979. Conserved plant genes with similarity to mammalian <i>de novo</i> DNA methyltransferases

Conserved plant genes with similarity to mammalian de novo DNA methyltransferases

10.1073/pnas.97.9.4979

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

DNA methylation plays a critical role in controlling states of gene activity in most eukaryotic organisms, and it is essential for proper growth and development. Patterns of methylation are established by de novo methyltransferases and maintained by maintenance methyltransferase activities. The Dnmt3 family of de novo DNA methyltransferases has recently been characterized in animals. Here we describe DNA methyltransferase genes from both Arabidopsis and maize that show a high level of sequence similarity to Dnmt3 , suggesting that they encode plant de novo methyltransferases. Relative to all known eukaryotic methyltransferases, these plant proteins contain a novel arrangement of the motifs required for DNA methyltransferase catalytic activity. The N termini of these methyltransferases contain a series of ubiquitin-associated (UBA) domains. UBA domains are found in several ubiquitin pathway proteins and in DNA repair enzymes such as Rad23, and they may be involved in ubiquitin binding. The presence of UBA domains provides a possible link between DNA methylation and ubiquitin/proteasome pathways.

Bibliography

Cao, X., Springer, N. M., Muszynski, M. G., Phillips, R. L., Kaeppler, S., & Jacobsen, S. E. (2000). Conserved plant genes with similarity to mammalian de novo DNA methyltransferases. Proceedings of the National Academy of Sciences, 97(9), 4979â4984.

Authors 6

Xiaofeng Cao (first)
Nathan M. Springer (additional)
Michael G. Muszynski (additional)
Ronald L. Phillips (additional)
Shawn Kaeppler (additional)
Steven E. Jacobsen (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:31 a.m.)
Deposited	3 years, 2 months ago (June 7, 2022, 1:34 a.m.)
Indexed	1 month ago (Aug. 5, 2025, 9:05 a.m.)
Issued	25 years, 4 months ago (April 25, 2000)
Published	25 years, 4 months ago (April 25, 2000)
Published Online	25 years, 4 months ago (April 25, 2000)
Published Print	25 years, 4 months ago (April 25, 2000)

Funders 0

None

BibTeX

@article{Cao_2000, title={Conserved plant genes with similarity to mammalian de novo DNA methyltransferases}, volume={97}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.97.9.4979}, DOI={10.1073/pnas.97.9.4979}, number={9}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Cao, Xiaofeng and Springer, Nathan M. and Muszynski, Michael G. and Phillips, Ronald L. and Kaeppler, Shawn and Jacobsen, Steven E.}, year={2000}, month=apr, pages={4979–4984} }

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