DOI: 10.1073/pnas.97.7.3655. Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human

Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human

10.1073/pnas.97.7.3655

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The cloned vanilloid receptor VR1 has attracted recent attention as a molecular integrator of painful stimuli on primary sensory neurons. The existence of vanilloid-sensitive neurons in the brain is, however, controversial. In this study, we have used an antibody and a complementary RNA probe to explore the distribution of neurons that express VR1 in rat and in certain areas of human brain. In the rat, we observed VR1-expressing neurons throughout the whole neuroaxis, including all cortical areas (in layers 3 and 5), several members of the limbic system (e.g., hippocampus, central amygdala, and both medial and lateral habenula), striatum, hypothalamus, centromedian and paraventricular thalamic nuclei, substantia nigra, reticular formation, locus coeruleus, cerebellum, and inferior olive. VR1-immunopositive cells also were found in the third and fifth layers of human parietal cortex. Reverse transcription–PCR performed with rat VR1-specific primers verified the expression of VR1 mRNA in cortex, hippocampus, and hypothalamus. In the central nervous system, neonatal capsaicin treatment depleted VR1 mRNA from the spinal nucleus of the trigeminal nerve, but not from other areas such as the inferior olive. The finding that VR1 is expressed not only in primary sensory neurons but also in several brain nuclei is of great importance in that it places VRs in a much broader perspective than pain perception. VRs in the brain (and putative endogenous vanilloids) may be involved in the control of emotions, learning, and satiety, just to name a few exciting possibilities.

Bibliography

Mezey, Ã., TÃ³th, Z. E., Cortright, D. N., Arzubi, M. K., Krause, J. E., Elde, R., Guo, A., Blumberg, P. M., & Szallasi, A. (2000). Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human. Proceedings of the National Academy of Sciences, 97(7), 3655â3660.

Authors 9

Éva Mezey (first)
Zsuzsanna E. Tóth (additional)
Daniel N. Cortright (additional)
Michelle K. Arzubi (additional)
James E. Krause (additional)
Robert Elde (additional)
Athena Guo (additional)
Peter M. Blumberg (additional)
Arpad Szallasi (additional)

References 50 Referenced 544

10.1016/0024-3205(69)90023-X
10.1038/270741a0
10.1002/cne.901900409
J D Wood Capsaicin in the Study of Pain (Academic, San Diego, 1993). / Capsaicin in the Study of Pain by Wood J D (1993)
A Szallasi, P M Blumberg Pharmacol Rev 51, 159–212 (1999). / Pharmacol Rev by Szallasi A (1999)
P Holzer Pharmacol Rev 43, 143–201 (1991). / Pharmacol Rev by Holzer P (1991)
P Geppetti, P Holzer Neurogenic Inflammation (CRC, Boca Raton, FL, 1996). / Neurogenic Inflammation by Geppetti P (1996)
P Holzer Am J Physiol 275, G8–G13 (1998). / Am J Physiol by Holzer P (1998)
10.1113/jphysiol.1970.sp009027
J Szolcsányi, A Jancsó-Gábor Arzneim-Forsch 25, 1877–1881 (1975). / Arzneim-Forsch by Szolcsányi J (1975)
10.1016/0006-8993(90)90498-Z
10.1016/S0024-3205(96)00537-1
10.1038/39807
10.1016/S0896-6273(00)80564-4
10.1097/00001756-199806220-00025
10.1046/j.1460-9568.1999.00503.x
10.1016/0003-2697(87)90021-2
10.1074/jbc.274.10.6330
S Ritter, T T Dinh Capsaicin in the Study of Pain, ed J N Wood (Academic, San Diego), pp. 105–138 (1993). / Capsaicin in the Study of Pain by Ritter S (1993)
10.1016/0006-8993(95)01094-7
10.1016/0006-8993(77)90483-8
10.1097/00001756-199507310-00028
10.1016/0165-3806(95)00056-J
10.1016/0169-328X(94)90158-9
10.1097/00001756-199511270-00016
10.1016/0014-2999(82)90602-1
10.1097/00001756-199210000-00007
10.1016/0361-9230(80)90216-6
10.1007/BF01244779
10.1038/229116a0
G Benedek, F Obal, Z Lelkes, F Obal Acta Physiol Acad Sci Hung 60, 27–35 (1982). / Acta Physiol Acad Sci Hung by Benedek G (1982)
10.1016/0028-3908(88)90162-1
10.1002/cne.903160304
10.1016/0006-8993(78)90146-4
10.1037/0735-7044.107.2.363
10.1016/0006-8993(81)91049-0
10.1016/S0031-6989(83)80090-3
10.1016/0006-8993(76)90907-0
10.1016/0028-3908(81)90006-X
10.1111/j.1471-4159.1992.tb10121.x
10.1016/0024-3205(81)90197-1
10.1007/BF01258524
10.1111/j.1748-1716.1987.tb08086.x
10.1016/S0079-6123(08)63799-1
10.1113/jphysiol.1990.sp018186
10.1016/S0074-7742(08)60373-6
10.1016/0304-3940(94)90780-3
10.1038/301515a0
10.1038/22761
10.1006/bbrc.1999.1105

Dates

Type	When
Created	13 years, 1 month ago (July 25, 2012, 1:37 p.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 5:24 p.m.)
Indexed	33 minutes ago (Aug. 30, 2025, 12:58 p.m.)
Issued	25 years, 5 months ago (March 21, 2000)
Published	25 years, 5 months ago (March 21, 2000)
Published Online	25 years, 5 months ago (March 21, 2000)
Published Print	25 years, 5 months ago (March 28, 2000)

Funders 0

None

BibTeX

@article{Mezey_2000, title={Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human}, volume={97}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.97.7.3655}, DOI={10.1073/pnas.97.7.3655}, number={7}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Mezey, Éva and Tóth, Zsuzsanna E. and Cortright, Daniel N. and Arzubi, Michelle K. and Krause, James E. and Elde, Robert and Guo, Athena and Blumberg, Peter M. and Szallasi, Arpad}, year={2000}, month=mar, pages={3655–3660} }

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