DOI: 10.1073/pnas.97.6.2626. Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis

Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis

10.1073/pnas.97.6.2626

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The activin receptor-like kinase 1 (ALK1) is a type I receptor for transforming growth factor-β (TGF-β) family proteins. Expression of ALK1 in blood vessels and mutations of the ALK1 gene in human type II hereditary hemorrhagic telangiectasia patients suggest that ALK1 may have an important role during vascular development. To define the function of ALK1 during development, we inactivated the ALK1 gene in mice by gene targeting. The ALK1 homozygous embryos die at midgestation, exhibiting severe vascular abnormalities characterized by excessive fusion of capillary plexes into cavernous vessels and hyperdilation of large vessels. These vascular defects are associated with enhanced expression of angiogenic factors and proteases and are characterized by deficient differentiation and recruitment of vascular smooth muscle cells. The blood vessel defects in ALK1-deficient mice are reminiscent of mice lacking TGF-β1, TGF-β type II receptor (TβR-II), or endoglin, suggesting that ALK1 may mediate TGF-β1 signal in endothelial cells. Consistent with this hypothesis, we demonstrate that ALK1 in endothelial cells binds to TGF-β1 and TβR-II. Furthermore, the ALK1 signaling pathway can inhibit TGF-β1-dependent transcriptional activation mediated by the known TGF-β1 type I receptor, ALK5. Taken together, our results suggest that the balance between the ALK1 and ALK5 signaling pathways in endothelial cells plays a crucial role in determining vascular endothelial properties during angiogenesis.

Bibliography

Oh, S. P., Seki, T., Goss, K. A., Imamura, T., Yi, Y., Donahoe, P. K., Li, L., Miyazono, K., ten Dijke, P., Kim, S., & Li, E. (2000). Activin receptor-like kinase 1 modulates transforming growth factor-Î²1 signaling in the regulation of angiogenesis. Proceedings of the National Academy of Sciences, 97(6), 2626â2631.

Authors 11

S. Paul Oh (first)
Tsugio Seki (additional)
Kendrick A. Goss (additional)
Takeshi Imamura (additional)
Youngsuk Yi (additional)
Patricia K. Donahoe (additional)
Li Li (additional)
Kohei Miyazono (additional)
Peter ten Dijke (additional)
Seongjin Kim (additional)
En Li (additional)

References 39 Referenced 698

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:40 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 5:30 p.m.)
Indexed	1 week, 4 days ago (Aug. 23, 2025, 12:58 a.m.)
Issued	25 years, 5 months ago (March 14, 2000)
Published	25 years, 5 months ago (March 14, 2000)
Published Online	25 years, 5 months ago (March 14, 2000)
Published Print	25 years, 5 months ago (March 14, 2000)

Funders 0

None

BibTeX

@article{Oh_2000, title={Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis}, volume={97}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.97.6.2626}, DOI={10.1073/pnas.97.6.2626}, number={6}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Oh, S. Paul and Seki, Tsugio and Goss, Kendrick A. and Imamura, Takeshi and Yi, Youngsuk and Donahoe, Patricia K. and Li, Li and Miyazono, Kohei and ten Dijke, Peter and Kim, Seongjin and Li, En}, year={2000}, month=mar, pages={2626–2631} }

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