DOI: 10.1073/pnas.96.9.5141. Murine natural killer cells contribute to the granulomatous reaction caused by mycobacterial cell walls

Murine natural killer cells contribute to the granulomatous reaction caused by mycobacterial cell walls

10.1073/pnas.96.9.5141

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Mice injected with deproteinized cell walls prepared from the strain H37rv ofMycobacterium tuberculosisdevelop a granuloma-like lesion in which NKT cells are predominant. NKT cells play a primary role in the granulomatous response, because the latter does not occur in Jα281−/−mice, which miss NKT cells. The glycolipidic fraction of the cell walls is responsible for the recruitment of NKT cells; the recruiting activity is associated with fractions containing phosphatidylinositolmannosides. These results define a powerful experimental set up for studying thein vivoinduction of NKT cell responses to microbial components.

Bibliography

Apostolou, I., Takahama, Y., Belmant, C., Kawano, T., Huerre, M., Marchal, G., Cui, J., Taniguchi, M., Nakauchi, H., FourniÃ©, J.-J., Kourilsky, P., & Gachelin, G. (1999). Murine natural killer cells contribute to the granulomatous reaction caused by mycobacterial cell walls. Proceedings of the National Academy of Sciences, 96(9), 5141â5146.

Authors 12

I. Apostolou (first)
Y. Takahama (additional)
C. Belmant (additional)
T. Kawano (additional)
M. Huerre (additional)
G. Marchal (additional)
J. Cui (additional)
M. Taniguchi (additional)
H. Nakauchi (additional)
J.-J. Fournié (additional)
P. Kourilsky (additional)
G. Gachelin (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:39 a.m.)
Deposited	2 years, 4 months ago (April 22, 2023, 8:24 a.m.)
Indexed	4 months, 3 weeks ago (March 31, 2025, 12:26 a.m.)
Issued	26 years, 4 months ago (April 27, 1999)
Published	26 years, 4 months ago (April 27, 1999)
Published Online	26 years, 4 months ago (April 27, 1999)
Published Print	26 years, 4 months ago (April 27, 1999)

Funders 0

None

BibTeX

@article{Apostolou_1999, title={Murine natural killer cells contribute to the granulomatous reaction caused by mycobacterial cell walls}, volume={96}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.96.9.5141}, DOI={10.1073/pnas.96.9.5141}, number={9}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Apostolou, I. and Takahama, Y. and Belmant, C. and Kawano, T. and Huerre, M. and Marchal, G. and Cui, J. and Taniguchi, M. and Nakauchi, H. and Fournié, J.-J. and Kourilsky, P. and Gachelin, G.}, year={1999}, month=apr, pages={5141–5146} }

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