Conservation of sequence and structure flanking the mouse and human β-globin loci: The β-globin genes are embedded within an array of odorant receptor genes
10.1073/pnas.96.9.5129
Crossref journal-article
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences (341)
Abstract

In mouse and human, the β-globin genes reside in a linear array that is associated with a positive regulatory element located 5′ to the genes known as the locus control region (LCR). The sequences of the mouse and human β-globin LCRs are homologous, indicating conservation of an essential function in β-globin gene regulation. We have sequenced regions flanking the β-globin locus in both mouse and human and found that homology associated with the LCR is more extensive than previously known, making up a conserved block of ≈40 kb. In addition, we have identified DNaseI-hypersensitive sites within the newly sequenced regions in both mouse and human, and these structural features also are conserved. Finally, we have found that both mouse and human β-globin loci are embedded within an array of odorant receptor genes that are expressed in olfactory epithelium, and we also identify an olfactory receptor gene located 3′ of the β-globin locus in chicken. The data demonstrate an evolutionarily conserved genomic organization for the β-globin locus and suggest a possible role for the β-globin LCR in control of expression of these odorant receptor genes and/or the presence of mechanisms to separate regulatory signals in different tissues.

Bibliography

Bulger, M., von Doorninck, J. H., Saitoh, N., Telling, A., Farrell, C., Bender, M. A., Felsenfeld, G., Axel, R., & Groudine, M. (1999). Conservation of sequence and structure flanking the mouse and human β-globin loci: The β-globin genes are embedded within an array of odorant receptor genes. Proceedings of the National Academy of Sciences, 96(9), 5129–5134.

Authors 9
  1. Michael Bulger (first)
  2. J. Hikke von Doorninck (additional)
  3. Noriko Saitoh (additional)
  4. Agnes Telling (additional)
  5. Catherine Farrell (additional)
  6. M. A. Bender (additional)
  7. Gary Felsenfeld (additional)
  8. Richard Axel (additional)
  9. Mark Groudine (additional)
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Dates
Type When
Created 23 years ago (July 26, 2002, 10:42 a.m.)
Deposited 3 years, 2 months ago (June 7, 2022, 12:42 a.m.)
Indexed 2 weeks, 2 days ago (Aug. 7, 2025, 4:27 p.m.)
Issued 26 years, 3 months ago (April 27, 1999)
Published 26 years, 3 months ago (April 27, 1999)
Published Online 26 years, 3 months ago (April 27, 1999)
Published Print 26 years, 3 months ago (April 27, 1999)
Funders 0

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@article{Bulger_1999, title={Conservation of sequence and structure flanking the mouse and human β-globin loci: The β-globin genes are embedded within an array of odorant receptor genes}, volume={96}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.96.9.5129}, DOI={10.1073/pnas.96.9.5129}, number={9}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Bulger, Michael and von Doorninck, J. Hikke and Saitoh, Noriko and Telling, Agnes and Farrell, Catherine and Bender, M. A. and Felsenfeld, Gary and Axel, Richard and Groudine, Mark}, year={1999}, month=apr, pages={5129–5134} }