Evolutionary relationships among diverse bacteriophages and prophages: All the world’s a phage
10.1073/pnas.96.5.2192
Crossref journal-article
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences (341)
Abstract

We report DNA and predicted protein sequence similarities, implying homology, among genes of double-stranded DNA (dsDNA) bacteriophages and prophages spanning a broad phylogenetic range of host bacteria. The sequence matches reported here establish genetic connections, not always direct, among the lambdoid phages of Escherichia coli , phage φC31 of Streptomyces , phages of Mycobacterium , a previously unrecognized cryptic prophage, φflu, in the Haemophilus influenzae genome, and two small prophage-like elements, φRv1 and φRv2, in the genome of Mycobacterium tuberculosis . The results imply that these phage genes, and very possibly all of the dsDNA tailed phages, share common ancestry. We propose a model for the genetic structure and dynamics of the global phage population in which all dsDNA phage genomes are mosaics with access, by horizontal exchange, to a large common genetic pool but in which access to the gene pool is not uniform for all phage.

Bibliography

Hendrix, R. W., Smith, M. C. M., Burns, R. N., Ford, M. E., & Hatfull, G. F. (1999). Evolutionary relationships among diverse bacteriophages and prophages: All the world’s a phage. Proceedings of the National Academy of Sciences, 96(5), 2192–2197.

Authors 5
  1. Roger W. Hendrix (first)
  2. Margaret C. M. Smith (additional)
  3. R. Neil Burns (additional)
  4. Michael E. Ford (additional)
  5. Graham F. Hatfull (additional)
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Dates
Type When
Created 23 years, 1 month ago (July 26, 2002, 10:42 a.m.)
Deposited 3 years, 2 months ago (June 7, 2022, 12:26 a.m.)
Indexed 4 days, 23 hours ago (Aug. 24, 2025, 6:52 p.m.)
Issued 26 years, 5 months ago (March 2, 1999)
Published 26 years, 5 months ago (March 2, 1999)
Published Online 26 years, 5 months ago (March 2, 1999)
Published Print 26 years, 5 months ago (March 2, 1999)
Funders 0

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@article{Hendrix_1999, title={Evolutionary relationships among diverse bacteriophages and prophages: All the world’s a phage}, volume={96}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.96.5.2192}, DOI={10.1073/pnas.96.5.2192}, number={5}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Hendrix, Roger W. and Smith, Margaret C. M. and Burns, R. Neil and Ford, Michael E. and Hatfull, Graham F.}, year={1999}, month=mar, pages={2192–2197} }