Identification of a cell protein (FIP-3) as a modulator of NF-κB activity and as a target of an adenovirus inhibitor of tumor necrosis factor α-induced apoptosis
10.1073/pnas.96.3.1042
Crossref journal-article
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences (341)
Abstract

FIP-3 (14.7K interacting protein) was discovered during a search for cell proteins that could interact with an adenovirus protein (Ad E3–14.7K) that had been shown to prevent tumor necrosis factor (TNF)-α-induced cytolysis. FIP-3, which contains leucine zippers and a zinc finger domain, inhibits both basal and induced transcriptional activity of NF-κB and causes a late-appearing apoptosis with unique morphologic manifestations. Ad E3–14.7K can partially reverse apoptotic death induced by FIP-3. FIP-3 also was shown to bind to other cell proteins, RIP and NIK, which previously had been described as essential components of TNF-α-induced NF-κB activation. In addition, FIP-3 inhibited activation of NF-κB induced by TNF-α, the TNFR-1 receptor, RIP, NIK, and IKKβ, as well as basal levels of endogenous NF-κB in 293 cells. Because the activation of NF-κB has been shown to inhibit apoptosis, FIP-3 appears both to activate a cell-death pathway and to inhibit an NF-κB-dependent survival mechanism.

Bibliography

Li, Y., Kang, J., Friedman, J., Tarassishin, L., Ye, J., Kovalenko, A., Wallach, D., & Horwitz, M. S. (1999). Identification of a cell protein (FIP-3) as a modulator of NF-κB activity and as a target of an adenovirus inhibitor of tumor necrosis factor α-induced apoptosis. Proceedings of the National Academy of Sciences, 96(3), 1042–1047.

Authors 8
  1. Yongan Li (first)
  2. Jian Kang (additional)
  3. Joshua Friedman (additional)
  4. Leonid Tarassishin (additional)
  5. Jianjiang Ye (additional)
  6. Andrei Kovalenko (additional)
  7. David Wallach (additional)
  8. Marshall S. Horwitz (additional)
References 49 Referenced 146
  1. W S M Wold, L R Gooding Virology 184, 1–8 (1991). (10.1016/0042-6822(91)90815-S) / Virology by Wold W S M (1991)
  2. W S M Wold, A E Tollefson, T W Hermiston The E3 Transcription Unit of Adenovirus, ed W Doerfler (Springer, Berlin) 199/1, 237–274 (1995). / The E3 Transcription Unit of Adenovirus by Wold W S M (1995)
  3. L R Gooding, I O Sofola, A E Tollefson, P J Duerksen-Hughes, W S M Wold J Immunol 145, 3080–3086 (1990). (10.4049/jimmunol.145.9.3080) / J Immunol by Gooding L R (1990)
  4. L R Gooding, T S Ranheim, A E Tollefson, L Aquino, P J Duerksen-Hughes, T M Horton, W S M Wold J Virol 65, 4114–4123 (1991). (10.1128/jvi.65.8.4114-4123.1991) / J Virol by Gooding L R (1991)
  5. C R Carlin, A E Tollefson, H A Brady, B L Hoffman, W S M Wold Cell 57, 135–144 (1989). (10.1016/0092-8674(89)90179-7) / Cell by Carlin C R (1989)
  6. A E Tollefson, T W Hermiston, D L Lichtenstein, C F Colle, R A Tripp, T Dimitrov, K Toth, C E Wells, P C Doherty, W S Wold Nature (London) 392, 726–730 (1998). (10.1038/33712) / Nature (London) by Tollefson A E (1998)
  7. J Shisler, C Yang, B Walter, C F Ware, L R Gooding J Virol 71, 8299–8306 (1997). (10.1128/jvi.71.11.8299-8306.1997) / J Virol by Shisler J (1997)
  8. A Hill, P Jugovic, I York, G Russ, J Bennink, J Yewdell, H Ploegh, D Johnson Nature (London) 375, 411–415 (1995). (10.1038/375411a0) / Nature (London) by Hill A (1995)
  9. G L Smith Curr Opin Immunol 8, 467–471 (1996). (10.1016/S0952-7915(96)80032-X) / Curr Opin Immunol by Smith G L (1996)
  10. S Kettle, A Alcami, A Khanna, R Ehret, C Jassoy, G L Smith J Gen Virol 78, 677–685 (1997). (10.1099/0022-1317-78-3-677) / J Gen Virol by Kettle S (1997)
  11. L Sedger, G McFadden Immunol Cell Biol 74, 538–545 (1996). (10.1038/icb.1996.87) / Immunol Cell Biol by Sedger L (1996)
  12. G McFadden, M Schreiber, L Sedger J Neuroimmunol 72, 119–126 (1997). (10.1016/S0165-5728(96)00177-4) / J Neuroimmunol by McFadden G (1997)
  13. E Wiertz, A Hill, D Tortorella, H Ploegh Immunol Lett 57, 213–216 (1997). (10.1016/S0165-2478(97)00073-4) / Immunol Lett by Wiertz E (1997)
  14. C A Smith, T Davis, J M Wignall, W S Din, T Farrah, C Upton, G McFadden, R G Goodwin Biochem Biophys Res Commun 176, 335–342 (1991). (10.1016/0006-291X(91)90929-2) / Biochem Biophys Res Commun by Smith C A (1991)
  15. X Du, S M Thiem J Virol 71, 7866–7872 (1997). (10.1128/jvi.71.10.7866-7872.1997) / J Virol by Du X (1997)
  16. P Chen, J Tian, I Kovesdi, J T Bruder J Biol Chem 273, 5815–5820 (1998). (10.1074/jbc.273.10.5815) / J Biol Chem by Chen P (1998)
  17. D Perez, E White J Cell Biol 141, 1255–1266 (1998). (10.1083/jcb.141.5.1255) / J Cell Biol by Perez D (1998)
  18. Y Li, J Kang, M S Horwitz J Virol 71, 1576–1582 (1997). (10.1128/jvi.71.2.1576-1582.1997) / J Virol by Li Y (1997)
  19. L R Gooding, L Aquino, P J Duerksen-Hughes, D Day, T M Horton, S Yei, W S M Wold J Virol 65, 3083–3094 (1991). (10.1128/jvi.65.6.3083-3094.1991) / J Virol by Gooding L R (1991)
  20. S N Farrow, J H White, I Martinou, T Raven, K T Pun, C J Grinham, J C Martinou, R Brown Nature (London) 374, 731–733 (1995). (10.1038/374731a0) / Nature (London) by Farrow S N (1995)
  21. J Han, H D Wallen, G Nunez, E White Mol Cell Biol 18, 6052–6062 (1998). (10.1128/MCB.18.10.6052) / Mol Cell Biol by Han J (1998)
  22. J L Cleveland, J N Ihle Cell 81, 479–482 (1995). (10.1016/0092-8674(95)90068-3) / Cell by Cleveland J L (1995)
  23. B Z Stanger, P Leder, T H Lee, E Kim, B Seed Cell 81, 513–523 (1995). (10.1016/0092-8674(95)90072-1) / Cell by Stanger B Z (1995)
  24. Z Liu, H Hsu, D V Goeddel, M Karin Cell 87, 565–575 (1996). (10.1016/S0092-8674(00)81375-6) / Cell by Liu Z (1996)
  25. H Hsu, J Xiong, D V Goeddel Cell 81, 495–504 (1995). (10.1016/0092-8674(95)90070-5) / Cell by Hsu H (1995)
  26. A M Chinnaiyan, K O’Rourke, M Tewari, V M Dixit Cell 81, 505–512 (1995). (10.1016/0092-8674(95)90071-3) / Cell by Chinnaiyan A M (1995)
  27. M P Boldin, E E Varfolomeev, Z Pancer, I L Mett, J H Camonis, D Wallach J Biol Chem 270, 7795–7798 (1995). (10.1074/jbc.270.14.7795) / J Biol Chem by Boldin M P (1995)
  28. M P Boldin, T M Goncharov, Y V Goltsev, D Wallach Cell 85, 803–815 (1996). (10.1016/S0092-8674(00)81265-9) / Cell by Boldin M P (1996)
  29. M Muzio, A M Chinnaiyan, F C Kischkel, J Ni, C Scaffidi, J D Bretz, M Zhang, R Gentz, M Mann, P H Krammer, et al. Cell 85, 817–827 (1996). (10.1016/S0092-8674(00)81266-0) / Cell by Muzio M (1996)
  30. A A Beg, D Baltimore Science 274, 782–784 (1996). (10.1126/science.274.5288.782) / Science by Beg A A (1996)
  31. D J Van Antwerp, S J Martin, T Kafri, D R Green, I M Verma Science 274, 787–789 (1996). (10.1126/science.274.5288.787) / Science by Van Antwerp D J (1996)
  32. N L Malinin, M P Boldin, A V Kovalenko, D Wallach Nature (London) 385, 540–544 (1997). (10.1038/385540a0) / Nature (London) by Malinin N L (1997)
  33. C H Regnier, H Y Song, X Gao, D V Goeddel, Z Cao, M Rothe Cell 90, 373–383 (1997). (10.1016/S0092-8674(00)80344-X) / Cell by Regnier C H (1997)
  34. H Hsu, J Huang, H-B Shu, V Baichwal, D V Goeddel Immunity 4, 387–396 (1996). (10.1016/S1074-7613(00)80252-6) / Immunity by Hsu H (1996)
  35. M A Kelliher, S Grimm, Y Ishida, F Kuo, B Z Stanger, P Leder Immunity 3, 297–303 (1998). (10.1016/S1074-7613(00)80535-X) / Immunity by Kelliher M A (1998)
  36. Y Li, J Kang, M S Horwitz Mol Cell Biol 18, 1601–1610 (1998). (10.1128/MCB.18.3.1601) / Mol Cell Biol by Li Y (1998)
  37. D Zilli, C Voelkel-Johnson, T Skinner, S M Laster Biochem Biophys Res Commun 188, 177–183 (1992). (10.1016/0006-291X(92)92366-6) / Biochem Biophys Res Commun by Zilli D (1992)
  38. Y Li, M S Horwitz BioTechniques 23, 1026–1029 (1997). (10.2144/97236bm12) / BioTechniques by Li Y (1997)
  39. E Zandi, D M Rothwarf, M Delhase, M Hayakawa, M Karin Cell 91, 243–252 (1997). (10.1016/S0092-8674(00)80406-7) / Cell by Zandi E (1997)
  40. D Xue, H R Horvitz Nature (London) 377, 248–251 (1995). (10.1038/377248a0) / Nature (London) by Xue D (1995)
  41. P W Faber, G T Barnes, J Srinidhi, J Chen, J F Gusella, M E MacDonald Hum Mol Genet 7, 1463–1474 (1998). (10.1093/hmg/7.9.1463) / Hum Mol Genet by Faber P W (1998)
  42. L Monney, I Otter, R Olivier, H L Ozer, A L Haas, S Omura, C Borner J Biol Chem 273, 6121–6131 (1998). (10.1074/jbc.273.11.6121) / J Biol Chem by Monney L (1998)
  43. R Schule, R M Evans Trends Genet 7, 377–381 (1991). (10.1016/0168-9525(91)90215-C) / Trends Genet by Schule R (1991)
  44. S Barnikol-Watanabe, N A Gross, H Gotz, T Henkel, A Karabinos, H Kratzin, H U Barnikol, N Hilschmann Biol Chem Hoppe-Seyler 375, 497–512 (1994). (10.1515/bchm3.1994.375.8.497) / Biol Chem Hoppe-Seyler by Barnikol-Watanabe S (1994)
  45. T Alber Curr Opin Genet Dev 2, 205–210 (1992). (10.1016/S0959-437X(05)80275-8) / Curr Opin Genet Dev by Alber T (1992)
  46. S Yamaoka, G Courtois, C Bessia, S T Whiteside, R Weil, F Agou, H E Kirk, R J Kay, A Israel Cell 93, 1231–1240 (1998). (10.1016/S0092-8674(00)81466-X) / Cell by Yamaoka S (1998)
  47. N Schreiber-Agus, L Chin, K Chen, R Torres, C T Thomson, J C Sacchettini, R A DePinho Oncogene 9, 3167–3177 (1994). / Oncogene by Schreiber-Agus N (1994)
  48. J M Boyd, G J Gallo, B Elangovan, A B Houghton, S Malstrom, B J Avery, R G Ebb, T Subramanian, T Chittenden, R J Lutz, et al. Oncogene 11, 1921–1928 (1995). / Oncogene by Boyd J M (1995)
  49. J M Boyd, S Malstrom, T Subramanian, L K Venkatesh, U Schaeper, B Elangovan, C D’Sa-Eipper, G Chinnadurai Cell 79, 341–351 (1994). (10.1016/0092-8674(94)90202-X) / Cell by Boyd J M (1994)
Dates
Type When
Created 23 years, 1 month ago (July 26, 2002, 10:42 a.m.)
Deposited 2 years, 4 months ago (April 22, 2023, 8:28 a.m.)
Indexed 1 year, 3 months ago (May 6, 2024, 1:17 p.m.)
Issued 26 years, 7 months ago (Feb. 2, 1999)
Published 26 years, 7 months ago (Feb. 2, 1999)
Published Online 26 years, 7 months ago (Feb. 2, 1999)
Published Print 26 years, 7 months ago (Feb. 2, 1999)
Funders 0

None

@article{Li_1999, title={Identification of a cell protein (FIP-3) as a modulator of NF-κB activity and as a target of an adenovirus inhibitor of tumor necrosis factor α-induced apoptosis}, volume={96}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.96.3.1042}, DOI={10.1073/pnas.96.3.1042}, number={3}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Li, Yongan and Kang, Jian and Friedman, Joshua and Tarassishin, Leonid and Ye, Jianjiang and Kovalenko, Andrei and Wallach, David and Horwitz, Marshall S.}, year={1999}, month=feb, pages={1042–1047} }