DOI: 10.1073/pnas.96.25.14342. Transport of torsional stress in DNA [Penn]

10.1073/pnas.96.25.14342

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

It is well known that transcription can induce torsional stress in DNA, affecting the activity of nearby genes or even inducing structural transitions in the DNA duplex. It has long been assumed that the generation of significant torsional stress requires the DNA to be anchored, forming a limited topological domain, because otherwise it would spin almost freely about its axis. Previous estimates of the rotational drag have, however, neglected the role of small natural bends in the helix backbone. We show how these bends can increase the drag several thousandfold relative to prior estimates, allowing significant torsional stress even in linear unanchored DNA. The model helps explain several puzzling experimental results on structural transitions induced by transcription of DNA.

Bibliography

Nelson, P. (1999). Transport of torsional stress in DNA. Proceedings of the National Academy of Sciences, 96(25), 14342â14347.

Authors 1

Philip Nelson (first)

References 45 Referenced 124

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:41 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 4:19 p.m.)
Indexed	1 month, 4 weeks ago (July 8, 2025, 6:26 a.m.)
Issued	25 years, 8 months ago (Dec. 7, 1999)
Published	25 years, 8 months ago (Dec. 7, 1999)
Published Online	25 years, 8 months ago (Dec. 7, 1999)
Published Print	25 years, 8 months ago (Dec. 7, 1999)

Funders 0

None

BibTeX

@article{Nelson_1999, title={Transport of torsional stress in DNA}, volume={96}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.96.25.14342}, DOI={10.1073/pnas.96.25.14342}, number={25}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Nelson, Philip}, year={1999}, month=dec, pages={14342–14347} }

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