DOI: 10.1073/pnas.96.24.13978. Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

10.1073/pnas.96.24.13978

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Apoptotic and necrotic cell death are well characterized and are influenced by intracellular ATP levels. Poly(ADP-ribose) polymerase (PARP), a nuclear enzyme activated by DNA strand breaks, physiologically participates in DNA repair. Overactivation of PARP after cellular insults can lead to cell death caused by depletion of the enzyme’s substrate β-nicotinamide adenine dinucleotide and of ATP. In this study, we have differentially elicited apoptosis or necrosis in mouse fibroblasts. Fibroblasts from PARP-deficient (PARP −/− ) mice are protected from necrotic cell death and ATP depletion but not from apoptotic death. These findings, together with cell death patterns in PARP −/− animals receiving other types of insults, indicate that PARP activation is an active trigger of necrosis, whereas other mechanisms mediate apoptosis.

Bibliography

Ha, H. C., & Snyder, S. H. (1999). Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion. Proceedings of the National Academy of Sciences, 96(24), 13978â13982.

Authors 2

Hyo Chol Ha (first)
Solomon H. Snyder (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:39 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 4:19 p.m.)
Indexed	4 days, 1 hour ago (Aug. 30, 2025, 12:40 p.m.)
Issued	25 years, 9 months ago (Nov. 23, 1999)
Published	25 years, 9 months ago (Nov. 23, 1999)
Published Online	25 years, 9 months ago (Nov. 23, 1999)
Published Print	25 years, 9 months ago (Nov. 23, 1999)

Funders 0

None

BibTeX

@article{Ha_1999, title={Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion}, volume={96}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.96.24.13978}, DOI={10.1073/pnas.96.24.13978}, number={24}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Ha, Hyo Chol and Snyder, Solomon H.}, year={1999}, month=nov, pages={13978–13982} }

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