DOI: 10.1073/pnas.96.21.11820. Direct molecular force measurements of multiple adhesive interactions between cadherin ectodomains

Direct molecular force measurements of multiple adhesive interactions between cadherin ectodomains

10.1073/pnas.96.21.11820

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Direct-force measurements of the interactions between recombinant C-cadherin from Xenopus demonstrated that the ectodomain of cadherin exhibits multiple adhesive contacts that involve successive domains along the extracellular region of the protein. Contacts between the fully interdigitated antiparallel proteins form the strongest adhesive interaction. A second weaker minimum was measured when the interdigitated proteins were separated by a distance equal to the length of one domain of the extracellular (EC) fragment and corresponding to the antiparallel alignment of domains one through four (EC1 through EC4). The successive rupture of these interactions generates an unbinding force profile that may be optimized to impede the abrupt failure of cadherin-mediated junctions under force.

Bibliography

Sivasankar, S., Brieher, W., Lavrik, N., Gumbiner, B., & Leckband, D. (1999). Direct molecular force measurements of multiple adhesive interactions between cadherin ectodomains. Proceedings of the National Academy of Sciences, 96(21), 11820â11824.

Authors 5

S. Sivasankar (first)
W. Brieher (additional)
N. Lavrik (additional)
B. Gumbiner (additional)
D. Leckband (additional)

References 36 Referenced 134

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:38 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 3:30 p.m.)
Indexed	1 month, 4 weeks ago (July 7, 2025, 8:04 a.m.)
Issued	25 years, 10 months ago (Oct. 12, 1999)
Published	25 years, 10 months ago (Oct. 12, 1999)
Published Online	25 years, 10 months ago (Oct. 12, 1999)
Published Print	25 years, 10 months ago (Oct. 12, 1999)

Funders 0

None

BibTeX

@article{Sivasankar_1999, title={Direct molecular force measurements of multiple adhesive interactions between cadherin ectodomains}, volume={96}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.96.21.11820}, DOI={10.1073/pnas.96.21.11820}, number={21}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Sivasankar, S. and Brieher, W. and Lavrik, N. and Gumbiner, B. and Leckband, D.}, year={1999}, month=oct, pages={11820–11824} }

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