DOI: 10.1073/pnas.96.16.9148. Heritable germ and somatic cell lineage competitions in chimeric colonial protochordates

Heritable germ and somatic cell lineage competitions in chimeric colonial protochordates

10.1073/pnas.96.16.9148

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Theories of evolution that state natural selection acts on individuals have been modified to include multiple levels of selection. Here we demonstrate in chimeric protochordates that primitive germ cell (pgc) and somatic cell (psc) lineages have traits that also make them likely units of natural selection. Specifically, by using microsatellites to determine the genetic identity of various somatic and gametic tissues within vascularly fused Botryllus schlosseri chimeras, we show that genetically distinct pgc and psc can compete for access to developing gonads and somatic organs, and that this competition is hierarchical, reproducible, and heritable. Given that a single, highly polymorphic locus (Fu/HC) controls whether two contacting colonies fuse or reject, our findings also support a leading hypothesis for why the highly polymorphic histocompatibility loci common to many metazoa may have arisen or been maintained: to limit supercompetitor lineages to histocompatible kin.

Bibliography

Stoner, D. S., Rinkevich, B., & Weissman, I. L. (1999). Heritable germ and somatic cell lineage competitions in chimeric colonial protochordates. Proceedings of the National Academy of Sciences, 96(16), 9148â9153.

Authors 3

Douglas S. Stoner (first)
Baruch Rinkevich (additional)
Irving L. Weissman (additional)

References 46 Referenced 159

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:38 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 4:50 p.m.)
Indexed	1 day, 20 hours ago (Aug. 29, 2025, 6:29 a.m.)
Issued	26 years ago (Aug. 3, 1999)
Published	26 years ago (Aug. 3, 1999)
Published Online	26 years ago (Aug. 3, 1999)
Published Print	26 years ago (Aug. 3, 1999)

Funders 0

None

BibTeX

@article{Stoner_1999, title={Heritable germ and somatic cell lineage competitions in chimeric colonial protochordates}, volume={96}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.96.16.9148}, DOI={10.1073/pnas.96.16.9148}, number={16}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Stoner, Douglas S. and Rinkevich, Baruch and Weissman, Irving L.}, year={1999}, month=aug, pages={9148–9153} }

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