DOI: 10.1073/pnas.96.15.8511. Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins

Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins

10.1073/pnas.96.15.8511

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Apoptosis signal-regulating kinase 1 (ASK1) is a pivotal component of a signaling pathway induced by many death stimuli, including tumor necrosis factor α, Fas, and the anticancer drugs cisplatin and paclitaxel. Here we report that ASK1 proapoptotic activity is antagonized by association with 14-3-3 proteins. We found that ASK1 specifically bound 14-3-3 proteins via a site involving Ser-967 of ASK1. Interestingly, overexpression of 14-3-3 in HeLa cells blocked ASK1-induced apoptosis whereas disruption of the ASK1/14-3-3 interaction dramatically accelerated ASK1-induced cell death. Targeting of ASK1 by a 14-3-3-mediated survival pathway may provide a novel mechanism for the suppression of apoptosis.

Bibliography

Zhang, L., Chen, J., & Fu, H. (1999). Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins. Proceedings of the National Academy of Sciences, 96(15), 8511â8515.

Authors 3

Lixin Zhang (first)
Jing Chen (additional)
Haian Fu (additional)

References 45 Referenced 310

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:38 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 4:36 p.m.)
Indexed	2 days, 20 hours ago (Sept. 4, 2025, 9:24 a.m.)
Issued	26 years, 1 month ago (July 20, 1999)
Published	26 years, 1 month ago (July 20, 1999)
Published Online	26 years, 1 month ago (July 20, 1999)
Published Print	26 years, 1 month ago (July 20, 1999)

Funders 0

None

BibTeX

@article{Zhang_1999, title={Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins}, volume={96}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.96.15.8511}, DOI={10.1073/pnas.96.15.8511}, number={15}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Zhang, Lixin and Chen, Jing and Fu, Haian}, year={1999}, month=jul, pages={8511–8515} }

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