DOI: 10.1073/pnas.96.11.6048. Long RNA hairpins that contain inosine are present in <i>Caenorhabditis elegans</i> poly(A) <sup>+</sup> RNA

Long RNA hairpins that contain inosine are present in Caenorhabditis elegans poly(A) + RNA

10.1073/pnas.96.11.6048

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Adenosine deaminases that act on RNA (ADARs) are RNA-editing enzymes that convert adenosine to inosine within double-stranded RNA. In the 12 years since the discovery of ADARs only a few natural substrates have been identified. These substrates were found by chance, when genomically encoded adenosines were identified as guanosines in cDNAs. To advance our understanding of the biological roles of ADARs, we developed a method for systematically identifying ADAR substrates. In our first application of the method, we identified five additional substrates in Caenorhabditis elegans . Four of those substrates are mRNAs edited in untranslated regions, and one is a noncoding RNA edited throughout its length. The edited regions are predicted to form long hairpin structures, and one of the RNAs encodes POP-1, a protein involved in cell fate decisions.

Bibliography

Morse, D. P., & Bass, B. L. (1999). Long RNA hairpins that contain inosine are present in Caenorhabditis elegans poly(A) + RNA. Proceedings of the National Academy of Sciences, 96(11), 6048â6053.

Authors 2

Daniel P. Morse (first)
Brenda L. Bass (additional)

References 29 Referenced 110

S Rueter, R Emeson Modification and Editing of RNA, eds H Grosjean, R Benne (Am. Soc. Microbiol., Washington, DC), pp. 343–361 (1998). / Modification and Editing of RNA by Rueter S (1998)
10.1016/S0968-0004(97)01035-9
B L Bass, K Nishikura, W Keller, P H Seeburg, R B Emeson, M A O’Connell, C E Samuel, A Herbert RNA 3, 947–949 (1997). / RNA by Bass B L (1997)
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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:39 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 4:35 p.m.)
Indexed	3 months ago (May 27, 2025, 10:58 a.m.)
Issued	26 years, 3 months ago (May 25, 1999)
Published	26 years, 3 months ago (May 25, 1999)
Published Online	26 years, 3 months ago (May 25, 1999)
Published Print	26 years, 3 months ago (May 25, 1999)

Funders 0

None

BibTeX

@article{Morse_1999, title={Long RNA hairpins that contain inosine are present in Caenorhabditis elegans poly(A) + RNA}, volume={96}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.96.11.6048}, DOI={10.1073/pnas.96.11.6048}, number={11}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Morse, Daniel P. and Bass, Brenda L.}, year={1999}, month=may, pages={6048–6053} }

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