DOI: 10.1073/pnas.95.8.4732. All-or-none potentiation at CA3-CA1 synapses

All-or-none potentiation at CA3-CA1 synapses

10.1073/pnas.95.8.4732

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The molecular mechanisms underlying long-term potentiation in the hippocampus have received much attention because of the likely functional importance of synaptic plasticity for information storage and the development of neuronal connectivity. Surprisingly, it remains unclear whether activity modifies the strength of individual synapses in a digital (all-or-none) or analog (graded) manner. Here we characterize step-like all-or-none transitions from baseline synaptic transmission to potentiated states following protocols for inducing potentiation at putative single CA3-CA1 synaptic connections. Individual synapses appear to have all-or-none potentiation indicative of highly cooperative processes but different thresholds for undergoing potentiation. These results raise the possibility that some forms of synaptic memory may be stored in a digital manner in the brain.

Bibliography

Petersen, C. C. H., Malenka, R. C., Nicoll, R. A., & Hopfield, J. J. (1998). All-or-none potentiation at CA3-CA1 synapses. Proceedings of the National Academy of Sciences, 95(8), 4732â4737.

Authors 4

Carl C. H. Petersen (first)
Robert C. Malenka (additional)
Roger A. Nicoll (additional)
John J. Hopfield (additional)

References 29 Referenced 272

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:35 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 3:46 p.m.)
Indexed	48 minutes ago (Sept. 4, 2025, 6:30 a.m.)
Issued	27 years, 4 months ago (April 14, 1998)
Published	27 years, 4 months ago (April 14, 1998)
Published Online	27 years, 4 months ago (April 14, 1998)
Published Print	27 years, 4 months ago (April 14, 1998)

Funders 0

None

BibTeX

@article{Petersen_1998, title={All-or-none potentiation at CA3-CA1 synapses}, volume={95}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.95.8.4732}, DOI={10.1073/pnas.95.8.4732}, number={8}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Petersen, Carl C. H. and Malenka, Robert C. and Nicoll, Roger A. and Hopfield, John J.}, year={1998}, month=apr, pages={4732–4737} }

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