DOI: 10.1073/pnas.95.8.4447. Extent of genomic rearrangement after genome duplication in yeast

Extent of genomic rearrangement after genome duplication in yeast

10.1073/pnas.95.8.4447

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Whole-genome duplication approximately 108years ago was proposed as an explanation for the many duplicated chromosomal regions inSaccharomyces cerevisiae. Here we have used computer simulations and analytic methods to estimate some parameters describing the evolution of the yeast genome after this duplication event. Computer simulation of a model in which 8% of the original genes were retained in duplicate after genome duplication, and 70–100 reciprocal translocations occurred between chromosomes, produced arrangements of duplicated chromosomal regions very similar to the map of real duplications in yeast. An analytical method produced an independent estimate of 84 map disruptions. These results imply that many smaller duplicated chromosomal regions exist in the yeast genome in addition to the 55 originally reported. We also examined the possibility of determining the original order of chromosomal blocks in the ancestral unduplicated genome, but this cannot be done without information from one or more additional species. If the genome sequence of one other species (such asKluyveromyces lactis) were known it should be possible to identify 150–200 paired regions covering the whole yeast genome and to reconstruct approximately two-thirds of the original order of blocks of genes in yeast. Rates of interchromosome translocation in yeast and mammals appear similar despite their very different rates of homologous recombination per kilobase.

Bibliography

Seoighe, C., & Wolfe, K. H. (1998). Extent of genomic rearrangement after genome duplication in yeast. Proceedings of the National Academy of Sciences, 95(8), 4447â4452.

Authors 2

Cathal Seoighe (first)
Kenneth H. Wolfe (additional)

References 28 Referenced 97

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:40 a.m.)
Deposited	1 year, 7 months ago (Jan. 4, 2024, 12:01 a.m.)
Indexed	1 month, 3 weeks ago (July 7, 2025, 8:04 a.m.)
Issued	27 years, 4 months ago (April 14, 1998)
Published	27 years, 4 months ago (April 14, 1998)
Published Online	27 years, 4 months ago (April 14, 1998)
Published Print	27 years, 4 months ago (April 14, 1998)

Funders 0

None

BibTeX

@article{Seoighe_1998, title={Extent of genomic rearrangement after genome duplication in yeast}, volume={95}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.95.8.4447}, DOI={10.1073/pnas.95.8.4447}, number={8}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Seoighe, Cathal and Wolfe, Kenneth H.}, year={1998}, month=apr, pages={4447–4452} }

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