DOI: 10.1073/pnas.95.7.3949. Virulence of antibiotic-resistant <i>Salmonella typhimurium</i>

Virulence of antibiotic-resistant Salmonella typhimurium

10.1073/pnas.95.7.3949

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

We show that most Salmonella typhimurium mutants resistant to streptomycin, rifampicin, and nalidixic acid are avirulent in mice. Of seven resistant mutants examined, six were avirulent and one was similar to the wild type in competition experiments in mice. The avirulent-resistant mutants rapidly accumulated various types of compensatory mutations that restored virulence without concomitant loss of resistance. Such second-site compensatory mutations were more common then reversion to the sensitive wild type. We infer from these results that a reduction in the use of antibiotics might not result in the disappearance of the resistant bacteria already present in human and environmental reservoirs. Thus, second-site compensatory mutations could increase the fitness of resistant bacteria and allow them to persist and compete successfully with sensitive strains even in an antibiotic-free environment.

Bibliography

BjÃ¶rkman, J., Hughes, D., & Andersson, D. I. (1998). Virulence of antibiotic-resistant Salmonella typhimurium. Proceedings of the National Academy of Sciences, 95(7), 3949â3953.

Authors 3

Johanna Björkman (first)
Diarmaid Hughes (additional)
Dan I. Andersson (additional)

References 19 Referenced 245

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J E Bouma, R E Lenski Nature (London) 335, 351–352 (1988). (10.1038/335351a0) / Nature (London) by Bouma J E (1988)
R E Lenski, S C Simpson, T T Nguyen J Bacteriol 176, 3140–3147 (1994). (10.1128/jb.176.11.3140-3147.1994) / J Bacteriol by Lenski R E (1994)
S J Schrag, V Perrot Nature (London) 381, 120–121 (1996). (10.1038/381120b0) / Nature (London) by Schrag S J (1996)
S Schrag, V Perrot, B R Levin Proc Royal Acad Sci 264, 1287–1291 (1997). (10.1098/rspb.1997.0178) / Proc Royal Acad Sci by Schrag S (1997)
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J Björkman, M Rhen, D I Andersson FEMS Microbiol Lett 139, 121–126 (1996). (10.1016/0378-1097(96)00129-2) / FEMS Microbiol Lett by Björkman J (1996)
R A LaRossa Escherichia coli and Salmonella, Cellular and Molecular Biology, ed F C Neidhardt, pp. 2527–2587 (1996). / Escherichia coli and Salmonella, Cellular and Molecular Biology by LaRossa R A (1996)
I Tubulekas, D Hughes Mol Microbiol 8, 761–770 (1993). (10.1111/j.1365-2958.1993.tb01619.x) / Mol Microbiol by Tubulekas I (1993)
U Bjare, L Gorini J Mol Biol 57, 423–435 (1971). (10.1016/0022-2836(71)90101-X) / J Mol Biol by Bjare U (1971)
D Donner, C G Kurland Mol Gen Genet 115, 49–53 (1972). (10.1007/BF00272217) / Mol Gen Genet by Donner D (1972)
R Hasenbank, C Guthrie, G Stöffler, H G Wittman, L Rosen, D Apirion Mol Gen Genet 127, 1–18 (1973). (10.1007/BF00267778) / Mol Gen Genet by Hasenbank R (1973)
M Olsson, L A Isaksson Mol Gen Genet 169, 259–269 (1979). (10.1007/BF00382272) / Mol Gen Genet by Olsson M (1979)
J Schnier, S Isono, A G Cumberlidge, K Isono Mol Gen Genet 199, 265–270 (1985). (10.1007/BF00330268) / Mol Gen Genet by Schnier J (1985)
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B R Levin, M Lipsitch, V Perrot, S Schrag, R Antia Clin Inf Dis 24, 9–16 (1997). (10.1093/clinids/24.Supplement_1.S9) / Clin Inf Dis by Levin B R (1997)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:42 a.m.)
Deposited	3 years, 2 months ago (June 6, 2022, 10:57 p.m.)
Indexed	2 months ago (July 2, 2025, 1:51 p.m.)
Issued	27 years, 5 months ago (March 31, 1998)
Published	27 years, 5 months ago (March 31, 1998)
Published Online	27 years, 5 months ago (March 31, 1998)
Published Print	27 years, 5 months ago (March 31, 1998)

Funders 0

None

BibTeX

@article{Bj_rkman_1998, title={Virulence of antibiotic-resistant Salmonella typhimurium}, volume={95}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.95.7.3949}, DOI={10.1073/pnas.95.7.3949}, number={7}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Björkman, Johanna and Hughes, Diarmaid and Andersson, Dan I.}, year={1998}, month=mar, pages={3949–3953} }

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