DOI: 10.1073/pnas.95.7.3925. Epithelial attachment alters the outcome of <i>Helicobacter pylori</i> infection

Epithelial attachment alters the outcome of Helicobacter pylori infection

10.1073/pnas.95.7.3925

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Genetically defined in vivo models are needed to assess the importance of target cell attachment in bacterial pathogenesis. Gastric colonization by Helicobacter pylori in human populations is common and persistent, and has various outcomes including peptic ulcers and cancer. The impact of attachment on the course of infection was examined in transgenic mice expressing a human receptor for H. pylori in their gastric epithelium. Persistent infection by a clinical isolate occurred at comparable microbial densities in transgenic and nontransgenic littermates. However, microbial attachment in transgenic mice resulted in production of autoantibodies to Lewis x carbohydrate epitopes shared by bacteria and acid-secreting parietal cells, chronic gastritis, and parietal cell loss. This model should help identify bacterial and host genes that produce attachment-related pathology.

Bibliography

Guruge, J. L., Falk, P. G., Lorenz, R. G., Dans, M., Wirth, H.-P., Blaser, M. J., Berg, D. E., & Gordon, J. I. (1998). Epithelial attachment alters the outcome of Helicobacter pylori infection. Proceedings of the National Academy of Sciences, 95(7), 3925â3930.

Authors 8

Janaki L. Guruge (first)
Per G. Falk (additional)
Robin G. Lorenz (additional)
Maria Dans (additional)
Hans-Peter Wirth (additional)
Martin J. Blaser (additional)
Douglas E. Berg (additional)
Jeffrey I. Gordon (additional)

References 37 Referenced 232

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:31 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 4:49 p.m.)
Indexed	3 weeks, 5 days ago (Aug. 7, 2025, 4:51 a.m.)
Issued	27 years, 5 months ago (March 31, 1998)
Published	27 years, 5 months ago (March 31, 1998)
Published Online	27 years, 5 months ago (March 31, 1998)
Published Print	27 years, 5 months ago (March 31, 1998)

Funders 0

None

BibTeX

@article{Guruge_1998, title={Epithelial attachment alters the outcome of Helicobacter pylori infection}, volume={95}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.95.7.3925}, DOI={10.1073/pnas.95.7.3925}, number={7}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Guruge, Janaki L. and Falk, Per G. and Lorenz, Robin G. and Dans, Maria and Wirth, Hans-Peter and Blaser, Martin J. and Berg, Douglas E. and Gordon, Jeffrey I.}, year={1998}, month=mar, pages={3925–3930} }

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