DOI: 10.1073/pnas.95.7.3851. Interferon α and Tat involvement in the immunosuppression of uninfected T cells and C-C chemokine decline in AIDS

Interferon α and Tat involvement in the immunosuppression of uninfected T cells and C-C chemokine decline in AIDS

10.1073/pnas.95.7.3851

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

HIV type 1 (HIV-1) not only directly kills infected CD4+T cells but also induces immunosuppression of uninfected T cells. Two immunosuppressive proteins, interferon α (IFNα) and extracellular Tat, mediate this process because specific antibodies against these proteins prevent generation of suppressor cells in HIV-1-infected peripheral blood mononuclear cell cultures. Furthermore, the production of C-C chemokines in response to immune cell activation, initially enhanced by IFNα and Tat, ultimately is inhibited by these proteins in parallel with their induction of immunosuppression. The clinical corollary is the immunosuppression of uninfected T cells and the decline in C-C chemokine release found at advanced stages of HIV-1 infection paralleling rising levels of IFNα and extracellular Tat. We, therefore, suggest that IFNα and Tat may be critical targets for anti-AIDS strategies.

Bibliography

Zagury, D., Lachgar, A., Chams, V., Fall, L. S., Bernard, J., Zagury, J.-F., Bizzini, B., Gringeri, A., Santagostino, E., Rappaport, J., Feldman, M., Burny, A., & Gallo, R. C. (1998). Interferon Î± and Tat involvement in the immunosuppression of uninfected T cells and C-C chemokine decline in AIDS. Proceedings of the National Academy of Sciences, 95(7), 3851â3856.

Authors 13

Daniel Zagury (first)
Abderrahim Lachgar (additional)
Vida Chams (additional)
Lat S. Fall (additional)
Jacky Bernard (additional)
Jean-François Zagury (additional)
Bernard Bizzini (additional)
Alessandro Gringeri (additional)
Elena Santagostino (additional)
Jay Rappaport (additional)
Michael Feldman (additional)
Arsène Burny (additional)
Robert C. Gallo (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:35 a.m.)
Deposited	2 years, 4 months ago (April 22, 2023, 8:15 a.m.)
Indexed	3 months, 2 weeks ago (May 17, 2025, 2:44 a.m.)
Issued	27 years, 5 months ago (March 31, 1998)
Published	27 years, 5 months ago (March 31, 1998)
Published Online	27 years, 5 months ago (March 31, 1998)
Published Print	27 years, 5 months ago (March 31, 1998)

Funders 0

None

BibTeX

@article{Zagury_1998, title={Interferon α and Tat involvement in the immunosuppression of uninfected T cells and C-C chemokine decline in AIDS}, volume={95}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.95.7.3851}, DOI={10.1073/pnas.95.7.3851}, number={7}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Zagury, Daniel and Lachgar, Abderrahim and Chams, Vida and Fall, Lat S. and Bernard, Jacky and Zagury, Jean-François and Bizzini, Bernard and Gringeri, Alessandro and Santagostino, Elena and Rappaport, Jay and Feldman, Michael and Burny, Arsène and Gallo, Robert C.}, year={1998}, month=mar, pages={3851–3856} }

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