DOI: 10.1073/pnas.95.6.3245. The absence of a major Ca <sup>2+</sup> signaling pathway in GABAergic neurons of the hippocampus

The absence of a major Ca 2+ signaling pathway in GABAergic neurons of the hippocampus

10.1073/pnas.95.6.3245

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The Ca 2+ /calmodulin-dependent protein phosphatase 2B or calcineurin (CN) participates in several Ca 2+ -dependent signal transduction cascades and, thus, contributes to the short and long term regulation of neuronal excitability. By using a specific antibody to CN, we demonstrate its absence from hippocampal interneurons and illustrate a physiological consequence of such CN deficiency. Consistent with the lack of CN in interneurons as detected by immunocytochemistry, the CN inhibitors FK-506 or okadaic acid significantly prolonged N -methyl- d -aspartate channel openings recorded in the cell-attached mode in hippocampal principal cells but not those recorded in interneurons. Interneurons were also devoid of Ca 2+ /calmodulin-dependent protein kinase IIα, yet many of their nuclei contained the cyclic AMP-responsive element binding protein. On the basis of the CN and Ca 2+ /calmodulin-dependent protein kinase IIα deficiency of interneurons, entirely different biochemical mechanisms are expected to govern Ca 2+ -dependent neuronal plasticity in interneurons versus principal cells.

Bibliography

SÃk, A., HÃ¡jos, N., GulÃ¡csi, A., Mody, I., & Freund, T. F. (1998). The absence of a major Ca 2+ signaling pathway in GABAergic neurons of theâhippocampus. Proceedings of the National Academy of Sciences, 95(6), 3245â3250.

Authors 5

Attila Sík (first)
Norbert Hájos (additional)
Alexandra Gulácsi (additional)
Istvan Mody (additional)
Tamás F. Freund (additional)

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Dates

Type	When
Created	23 years ago (July 26, 2002, 10:35 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 4:19 p.m.)
Indexed	3 weeks ago (Aug. 3, 2025, 12:20 a.m.)
Issued	27 years, 5 months ago (March 17, 1998)
Published	27 years, 5 months ago (March 17, 1998)
Published Online	27 years, 5 months ago (March 17, 1998)
Published Print	27 years, 5 months ago (March 17, 1998)

Funders 0

None

BibTeX

@article{S_k_1998, title={The absence of a major Ca 2+ signaling pathway in GABAergic neurons of the hippocampus}, volume={95}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.95.6.3245}, DOI={10.1073/pnas.95.6.3245}, number={6}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Sík, Attila and Hájos, Norbert and Gulácsi, Alexandra and Mody, Istvan and Freund, Tamás F.}, year={1998}, month=mar, pages={3245–3250} }

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