DOI: 10.1073/pnas.95.5.2296. The yeast nascent polypeptide-associated complex initiates protein targeting to mitochondria <i>in vivo</i>

The yeast nascent polypeptide-associated complex initiates protein targeting to mitochondria in vivo

10.1073/pnas.95.5.2296

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The yeast nascent polypeptide-associated complex (NAC) is encoded by two genes, EGD1 and EGD2 , and is associated with cytoplasmic ribosomes. Yeast mutants lacking NAC (Δ egd2 ) are viable but suffer slight defects in the targeting of nascent polypeptides to several locations including the endoplasmic reticulum and mitochondria. If both NAC and Mft52p are missing from yeast cells, inefficient targeting of mitochondrial precursor proteins leads to defects in both mitochondrial function and morphology. We suggest that NAC provides a ribosomal environment for nascent mitochondrial targeting sequences to achieve secondary structure, thereby enhancing the efficiency of protein targeting.

Bibliography

George, R., Beddoe, T., Landl, K., & Lithgow, T. (1998). The yeast nascent polypeptide-associated complex initiates protein targeting to mitochondria in vivo. Proceedings of the National Academy of Sciences, 95(5), 2296â2301.

Authors 4

Rebecca George (first)
Travis Beddoe (additional)
Karina Landl (additional)
Trevor Lithgow (additional)

References 39 Referenced 125

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:35 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 4:36 p.m.)
Indexed	5 days, 12 hours ago (Aug. 31, 2025, 6:34 a.m.)
Issued	27 years, 6 months ago (March 3, 1998)
Published	27 years, 6 months ago (March 3, 1998)
Published Online	27 years, 6 months ago (March 3, 1998)
Published Print	27 years, 6 months ago (March 3, 1998)

Funders 0

None

BibTeX

@article{George_1998, title={The yeast nascent polypeptide-associated complex initiates protein targeting to mitochondria in vivo}, volume={95}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.95.5.2296}, DOI={10.1073/pnas.95.5.2296}, number={5}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={George, Rebecca and Beddoe, Travis and Landl, Karina and Lithgow, Trevor}, year={1998}, month=mar, pages={2296–2301} }

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