DOI: 10.1073/pnas.95.3.803. Spatially independent activity patterns in functional MRI data during the Stroop color-naming task

Spatially independent activity patterns in functional MRI data during the Stroop color-naming task

10.1073/pnas.95.3.803

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

A method is given for determining the time course and spatial extent of consistently and transiently task-related activations from other physiological and artifactual components that contribute to functional MRI (fMRI) recordings. Independent component analysis (ICA) was used to analyze two fMRI data sets from a subject performing 6-min trials composed of alternating 40-sec Stroop color-naming and control task blocks. Each component consisted of a fixed three-dimensional spatial distribution of brain voxel values (a “map”) and an associated time course of activation. For each trial, the algorithm detected, without a priori knowledge of their spatial or temporal structure, one consistently task-related component activated during each Stroop task block, plus several transiently task-related components activated at the onset of one or two of the Stroop task blocks only. Activation patterns occurring during only part of the fMRI trial are not observed with other techniques, because their time courses cannot easily be known in advance. Other ICA components were related to physiological pulsations, head movements, or machine noise. By using higher-order statistics to specify stricter criteria for spatial independence between component maps, ICA produced improved estimates of the temporal and spatial extent of task-related activation in our data compared with principal component analysis (PCA). ICA appears to be a promising tool for exploratory analysis of fMRI data, particularly when the time courses of activation are not known in advance.

Bibliography

McKeown, M. J., Jung, T.-P., Makeig, S., Brown, G., Kindermann, S. S., Lee, T.-W., & Sejnowski, T. J. (1998). Spatially independent activity patterns in functional MRI data during the Stroop color-namingâtask. Proceedings of the National Academy of Sciences, 95(3), 803â810.

Authors 7

Martin J. McKeown (first)
Tzyy-Ping Jung (additional)
Scott Makeig (additional)
Greg Brown (additional)
Sandra S. Kindermann (additional)
Te-Won Lee (additional)
Terrence J. Sejnowski (additional)

References 27 Referenced 361

K J Friston Brain Mapping, The Methods, eds A W Toga, J C Mazziotta (Academic, San Diego), pp. 363–396 (1996). / Brain Mapping, The Methods by Friston K J (1996)
W H Press, S A Teukolsky, W T Vetterling, B P Flannery Numerical Recipes in C: The Art of Scientific Computing (Cambridge Univ. Press, Cambridge, UK, 1992). / Numerical Recipes in C: The Art of Scientific Computing by Press W H (1992)
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10.1073/pnas.93.25.14878
10.1002/mrm.1910370427
10.1038/jcbfm.1993.4
E Gardner Fundamentals of Neurology (W. B. Saunders, Philadelphia, 1975). / Fundamentals of Neurology by Gardner E (1975)
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10.1006/cbmr.1996.0014
10.1111/j.1600-0404.1992.tb04009.x
10.1080/01688639208402865
10.1016/0028-3932(93)90147-R
McKeown M. J. Makeig S. Brown G. G. Jung T.-P. Kindermann S. S. Bell A. J. & Sejnowski T. J. (1998) Hum. Brain Mapping in press.
10.1093/cercor/6.1.71
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T-W Lee, T J Sejnowski Joint Symp Neural Comput, 4th Institute for Neural Computation, UCSD 7, 132–140 (1997). / Joint Symp Neural Comput, 4th Institute for Neural Computation, UCSD by Lee T-W (1997)
M Girolami, C Fyfe IEEE International Conference on Neural Networks (Houston, TX), pp. 1788–1791 (1997). / IEEE International Conference on Neural Networks by Girolami M (1997)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:40 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 4:26 p.m.)
Indexed	1 month ago (Aug. 2, 2025, 1:13 a.m.)
Issued	27 years, 7 months ago (Feb. 3, 1998)
Published	27 years, 7 months ago (Feb. 3, 1998)
Published Online	27 years, 7 months ago (Feb. 3, 1998)
Published Print	27 years, 7 months ago (Feb. 3, 1998)

Funders 0

None

BibTeX

@article{McKeown_1998, title={Spatially independent activity patterns in functional MRI data during the Stroop color-naming task}, volume={95}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.95.3.803}, DOI={10.1073/pnas.95.3.803}, number={3}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={McKeown, Martin J. and Jung, Tzyy-Ping and Makeig, Scott and Brown, Greg and Kindermann, Sandra S. and Lee, Te-Won and Sejnowski, Terrence J.}, year={1998}, month=feb, pages={803–810} }

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