DOI: 10.1073/pnas.95.3.765. Behind the scenes of functional brain imaging: A historical and physiological perspective

Behind the scenes of functional brain imaging: A historical and physiological perspective

10.1073/pnas.95.3.765

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

At the forefront of cognitive neuroscience research in normal humans are the new techniques of functional brain imaging: positron emission tomography and magnetic resonance imaging. The signal used by positron emission tomography is based on the fact that changes in the cellular activity of the brain of normal, awake humans and laboratory animals are accompanied almost invariably by changes in local blood flow. This robust, empirical relationship has fascinated scientists for well over a hundred years. Because the changes in blood flow are accompanied by lesser changes in oxygen consumption, local changes in brain oxygen content occur at the sites of activation and provide the basis for the signal used by magnetic resonance imaging. The biological basis for these signals is now an area of intense research stimulated by the interest in these tools for cognitive neuroscience research.

Bibliography

Raichle, M. E. (1998). Behind the scenes of functional brain imaging: A historical and physiologicalâperspective. Proceedings of the National Academy of Sciences, 95(3), 765â772.

Authors 1

Marcus E. Raichle (first)

References 86 Referenced 485

M E Raichle Handbook of Physiology: The Nervous System V: Higher Functions of the Brain, ed F Plum (Am. Physiol. Soc., Bethesda, MD), pp. 643–674 (1987). / Handbook of Physiology: The Nervous System V: Higher Functions of the Brain by Raichle M E (1987)
10.1073/pnas.83.4.1140
Fox P. T. Raichle M. E. Mintun M. A. & Dence C. (1988) Science 241 . (10.1126/science.3260686)
10.1073/pnas.87.24.9868
10.1073/pnas.89.13.5951
10.1073/pnas.89.12.5675
10.1002/mrm.1910250220
10.1002/jmri.1880020505
10.1113/jphysiol.1890.sp000321
B K Siesjo Brain Energy Metabolism (Wiley, New York, 1978). / Brain Energy Metabolism by Siesjo B K (1978)
10.1073/pnas.83.4.1140
10.1111/j.1748-1716.1994.tb09718.x
W James Principles of Psychology (Henry Holt, New York), pp. 97–99 (1890). / Principles of Psychology by James W (1890)
10.1515/9783112360606
P Broca Bull Acad Med (Paris) 2S, 1331–1347 (1879). / Bull Acad Med (Paris) by Broca P (1879)
P Broca Bull Soc Anatomique (Paris) 6, 330–357, , 398–407. (1861). / Bull Soc Anatomique (Paris) by Broca P (1861)
A Mosso La Temperature del Cervello (Milan, 1894). / La Temperature del Cervello by Mosso A (1894)
H Berger Zur Lehre von der Blutzirkulation in der Schandelhohle des Menschen (von Gustav, Fischer, Jena, Germany, 1901). / Zur Lehre von der Blutzirkulation in der Schandelhohle des Menschen by Berger H (1901)
L Hill The Physiology and Pathology of the Cerebral Circulation: An Experimental Research (Churchill, London, 1896). / The Physiology and Pathology of the Cerebral Circulation: An Experimental Research by Hill L (1896)
10.1093/cercor/7.3.193
W M Landau, W H Freygang, L P Roland, L Sokoloff, S Kety Trans Am Neurol Assoc 80, 125–129 (1955). / Trans Am Neurol Assoc by Landau W M (1955)
S Kety Methods Med Res 8, 228–236 (1960). / Methods Med Res by Kety S (1960)
10.1111/j.1471-4159.1977.tb10649.x
10.1161/01.RES.44.1.127
10.1212/WNL.13.9.719
G H Ingvar, J Risberg Acta Neurol Scand Suppl 14, 183–186 (1965). / Acta Neurol Scand Suppl by Ingvar G H (1965)
S Kety Acta Neurol Scand Suppl 14, 197, (abstr.). (1965). / Acta Neurol Scand Suppl by Kety S (1965)
10.1038/scientificamerican1078-62
10.1259/0007-1285-46-552-1016
10.1063/1.1729798
10.1088/0031-9155/18/2/003
10.1148/114.1.89
E J Hoffman, M E Phelps, N A Mullani, C S Higgins, M M Ter-Pogossian J Nucl Med 17, 493–502 (1976). / J Nucl Med by Hoffman E J (1976)
M E Raichle, W R W Martin, P Herscovitch, M A Mintun, J Markham J Nucl Med 24, 790–798 (1983). / J Nucl Med by Raichle M E (1983)
10.1097/00004728-198012000-00001
M A Mintun, M E Raichle, W R W Martin, P Herscovitch J Nucl Med 25, 177–187 (1984). / J Nucl Med by Mintun M A (1984)
D I Altman, L L Lich, W J Powers J Nucl Med 32, 1738–1741 (1991). / J Nucl Med by Altman D I (1991)
M I Posner, M E Raichle Images of Mind (Freeman, New York, 1994). / Images of Mind by Posner M I (1994)
10.1016/0001-6918(69)90065-1
10.1093/cercor/4.1.8
10.1103/PhysRev.70.460
10.1103/PhysRev.69.37
10.1038/242190a0
10.1073/pnas.22.4.210
10.1016/0304-4165(82)90333-6
10.1002/mrm.1910380110
10.1073/pnas.80.13.4179
10.1162/jocn.1997.9.5.648
10.1523/JNEUROSCI.02-11-01527.1982
10.1523/JNEUROSCI.04-01-00251.1984
D D Heistad, H A Kontos Handbook of Physiology: The Cardiovascular System, eds J T Sheppard, F M Abboud (Am. Physiol. Soc., Bethesda, MD) 3, 137–182 (1983). / Handbook of Physiology: The Cardiovascular System by Heistad D D (1983)
10.1007/BF00249600
10.1002/ana.410140203
10.1161/01.STR.23.6.855
W Penfield Res Pub Assoc Res Nervous Mental Disorder 18, 605–637 (1937). / Res Pub Assoc Res Nervous Mental Disorder by Penfield W (1937)
10.1001/archneur.1968.00470310015001
D C Howse, F Plum, T E Duffy, L G Salford Trans Am Neurol Assoc 98, 153–155 (1973). / Trans Am Neurol Assoc by Howse D C (1973)
10.1007/978-3-642-65814-3_97
10.1016/0006-8993(66)90075-8
R Cooper, D Papakostopoulos, H J Crow Blood Flow and Metabolism in the Brain, eds A M Harper, W B Jennett, J D Miller, J O Rowan (Churchill Livingstone, New York), pp. 14.8–14.9 (1975). / Blood Flow and Metabolism in the Brain by Cooper R (1975)
10.1523/JNEUROSCI.16-03-00877.1996
10.1097/00004647-199611000-00001
O D Creutzfeldt Brain Work: The Coupling of Function, Metabolism and Blood Flow in the Brain, eds D H Ingvar, N A Lassen (Munksgaard, Copenhagen), pp. 21–46 (1975). / Brain Work: The Coupling of Function, Metabolism and Blood Flow in the Brain by Creutzfeldt O D (1975)
M Chesler, R P Kraig Am J Psychol 253, R666–R670 (1987). / Am J Psychol by Chesler M (1987)
10.1126/science.6298937
10.1016/0306-4522(92)90329-Z
10.1016/0304-3940(93)90215-7
10.1038/jcbfm.1991.107
10.1038/jcbfm.1991.106
10.1515/bchm3.1993.374.1-6.343
10.1002/cne.903220307
10.1073/pnas.88.13.5829
10.1038/jcbfm.1988.89
10.1002/mrm.1910350202
10.1073/pnas.93.15.7612
10.1002/(SICI)1097-0193(1997)5:2<93::AID-HBM3>3.0.CO;2-H
10.1126/science.272.5261.551
10.1002/mrm.1910370612
10.1097/00004647-199701000-00009
10.1093/cercor/6.5.647
J H Greenberg, N W Sohn, P J Hand J Cereb Blood Flow Metab 17, S561, (abstr.). (1997). / J Cereb Blood Flow Metab by Greenberg J H (1997)
W J Powers, I B Hirsch, P E Cryer Am J Physiol 270, H554–H559 (1996). / Am J Physiol by Powers W J (1996)
10.1038/331585a0
10.1162/jocn.1989.1.2.153
10.1523/JNEUROSCI.15-01-00012.1995
10.1093/brain/51.3.310

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:40 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 4:26 p.m.)
Indexed	3 days, 17 hours ago (Aug. 30, 2025, 12:35 p.m.)
Issued	27 years, 7 months ago (Feb. 3, 1998)
Published	27 years, 7 months ago (Feb. 3, 1998)
Published Online	27 years, 7 months ago (Feb. 3, 1998)
Published Print	27 years, 7 months ago (Feb. 3, 1998)

Funders 0

None

BibTeX

@article{Raichle_1998, title={Behind the scenes of functional brain imaging: A historical and physiological perspective}, volume={95}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.95.3.765}, DOI={10.1073/pnas.95.3.765}, number={3}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Raichle, Marcus E.}, year={1998}, month=feb, pages={765–772} }

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