DOI: 10.1073/pnas.95.3.1178. Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

10.1073/pnas.95.3.1178

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The priming of tumor-antigen-specific T cells is critical for the initiation of successful anti-tumor immune responses, yet the fate of such cells during tumor progression is unknown. Naive CD4+T cells specific for an antigen expressed by tumor cells were transferred into tumor-bearing mice. Transient clonal expansion occurred early after transfer, accompanied by phenotypic changes associated with antigen recognition. Nevertheless, these cells had a diminished response to peptide antigenin vitroand were unable to be primedin vivo. The development of antigen-specific T cell anergy is an early event in the tumor-bearing host, and it suggests that tolerance to tumor antigens may impose a significant barrier to therapeutic vaccination.

Bibliography

Staveley-OâCarroll, K., Sotomayor, E., Montgomery, J., Borrello, I., Hwang, L., Fein, S., Pardoll, D., & Levitsky, H. (1998). Induction of antigen-specific T cell anergy: An early event in the course of tumorâprogression. Proceedings of the National Academy of Sciences, 95(3), 1178â1183.

Authors 8

Kevin Staveley-O’Carroll (first)
Eduardo Sotomayor (additional)
Jami Montgomery (additional)
Ivan Borrello (additional)
Leon Hwang (additional)
Steve Fein (additional)
Drew Pardoll (additional)
Hyam Levitsky (additional)

References 36 Referenced 532

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:40 a.m.)
Deposited	2 years, 4 months ago (April 22, 2023, 8:26 a.m.)
Indexed	6 days, 11 hours ago (Aug. 29, 2025, 6 a.m.)
Issued	27 years, 7 months ago (Feb. 3, 1998)
Published	27 years, 7 months ago (Feb. 3, 1998)
Published Online	27 years, 7 months ago (Feb. 3, 1998)
Published Print	27 years, 7 months ago (Feb. 3, 1998)

Funders 0

None

BibTeX

@article{Staveley_O_Carroll_1998, title={Induction of antigen-specific T cell anergy: An early event in the course of tumor progression}, volume={95}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.95.3.1178}, DOI={10.1073/pnas.95.3.1178}, number={3}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Staveley-O’Carroll, Kevin and Sotomayor, Eduardo and Montgomery, Jami and Borrello, Ivan and Hwang, Leon and Fein, Steve and Pardoll, Drew and Levitsky, Hyam}, year={1998}, month=feb, pages={1178–1183} }

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