DOI: 10.1073/pnas.95.26.15849. The <i>Arabidopsis thaliana RPM1</i> disease resistance gene product is a peripheral plasma membrane protein that is degraded coincident with the hypersensitive response

The Arabidopsis thaliana RPM1 disease resistance gene product is a peripheral plasma membrane protein that is degraded coincident with the hypersensitive response

10.1073/pnas.95.26.15849

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Disease resistance in plants is often controlled by a gene-for-gene mechanism in which avirulence ( avr ) gene products encoded by pathogens are specifically recognized, either directly or indirectly, by plant disease resistance ( R ) gene products. Members of the NBS-LRR class of R genes encode proteins containing a putative nucleotide binding site (NBS) and carboxyl-terminal leucine-rich repeats (LRRs). Generally, NBS-LRR proteins do not contain predicted transmembrane segments or signal peptides, suggesting they are soluble cytoplasmic proteins. RPM1 is an NBS-LRR protein from Arabidopsis thaliana that confers resistance to Pseudomonas syringae expressing either avrRpm1 or avrB . RPM1 protein was localized by using an epitope tag. In contrast to previous suggestions, RPM1 is a peripheral membrane protein that likely resides on the cytoplasmic face of the plasma membrane. Furthermore, RPM1 is degraded coincident with the onset of the hypersensitive response, suggesting a negative feedback loop controlling the extent of cell death and overall resistance response at the site of infection.

Bibliography

Boyes, D. C., Nam, J., & Dangl, J. L. (1998). The Arabidopsis thaliana RPM1 disease resistance gene product is a peripheral plasma membrane protein that is degraded coincident with the hypersensitive response. Proceedings of the National Academy of Sciences, 95(26), 15849â15854.

Authors 3

Douglas C. Boyes (first)
Jaesung Nam (additional)
Jeffery L. Dangl (additional)

References 34 Referenced 320

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:40 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 4:07 p.m.)
Indexed	1 week, 6 days ago (Aug. 21, 2025, 12:57 p.m.)
Issued	26 years, 8 months ago (Dec. 22, 1998)
Published	26 years, 8 months ago (Dec. 22, 1998)
Published Online	26 years, 8 months ago (Dec. 22, 1998)
Published Print	26 years, 8 months ago (Dec. 22, 1998)

Funders 0

None

BibTeX

@article{Boyes_1998, title={The Arabidopsis thaliana RPM1 disease resistance gene product is a peripheral plasma membrane protein that is degraded coincident with the hypersensitive response}, volume={95}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.95.26.15849}, DOI={10.1073/pnas.95.26.15849}, number={26}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Boyes, Douglas C. and Nam, Jaesung and Dangl, Jeffery L.}, year={1998}, month=dec, pages={15849–15854} }

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