DOI: 10.1073/pnas.95.25.14863. Cluster analysis and display of genome-wide expression patterns

Cluster analysis and display of genome-wide expression patterns

10.1073/pnas.95.25.14863

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

A system of cluster analysis for genome-wide expression data from DNA microarray hybridization is described that uses standard statistical algorithms to arrange genes according to similarity in pattern of gene expression. The output is displayed graphically, conveying the clustering and the underlying expression data simultaneously in a form intuitive for biologists. We have found in the budding yeast Saccharomyces cerevisiae that clustering gene expression data groups together efficiently genes of known similar function, and we find a similar tendency in human data. Thus patterns seen in genome-wide expression experiments can be interpreted as indications of the status of cellular processes. Also, coexpression of genes of known function with poorly characterized or novel genes may provide a simple means of gaining leads to the functions of many genes for which information is not available currently.

Bibliography

Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D. (1998). Cluster analysis and display of genome-wide expression patterns. Proceedings of the National Academy of Sciences, 95(25), 14863â14868.

Authors 4

Michael B. Eisen (first)
Paul T. Spellman (additional)
Patrick O. Brown (additional)
David Botstein (additional)

References 16 Referenced 12,343

10.1126/science.270.5235.467
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10.1126/science.278.5338.680
Spellman P. T. Sherlock G. Iyer V. R. Zhang M. Anders K. Eisen M. B. Brown P. O. Botstein D. & Futcher B. (1998). Mol. Biol. Cell in press.
10.1126/science.282.5389.699
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Dates

Type	When
Created	23 years ago (July 26, 2002, 10:35 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 5:01 p.m.)
Indexed	19 hours, 7 minutes ago (Aug. 21, 2025, 2:16 p.m.)
Issued	26 years, 8 months ago (Dec. 8, 1998)
Published	26 years, 8 months ago (Dec. 8, 1998)
Published Online	26 years, 8 months ago (Dec. 8, 1998)
Published Print	26 years, 8 months ago (Dec. 8, 1998)

Funders 0

None

BibTeX

@article{Eisen_1998, title={Cluster analysis and display of genome-wide expression patterns}, volume={95}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.95.25.14863}, DOI={10.1073/pnas.95.25.14863}, number={25}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Eisen, Michael B. and Spellman, Paul T. and Brown, Patrick O. and Botstein, David}, year={1998}, month=dec, pages={14863–14868} }

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