DOI: 10.1073/pnas.95.25.14787. Pontin52, an interaction partner of β-catenin, binds to the TATA box binding protein

Pontin52, an interaction partner of β-catenin, binds to the TATA box binding protein

10.1073/pnas.95.25.14787

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

β-catenin, the vertebrate homolog of the Drosophila Armadillo protein, has been shown to have dual cellular functions, as a component of both the cadherin-catenin cell adhesion complex and the Wnt signaling pathway. At Wnt signaling, β-catenin becomes stabilized in the cytoplasm and subsequently available for interaction with transcription factors of the lymphocyte enhancer factor-1/T-cell factor family, resulting in a nuclear localization of β-catenin. Although β-catenin does not bind DNA directly, its carboxyl- and amino-terminal regions exhibit a transactivating activity still not well understood molecularly. Here we report the identification of an interaction partner of β-catenin, a nuclear protein designated Pontin52. Pontin52 binds β-catenin in the region of Armadillo repeats 2–5 and, more importantly, also binds the TATA box binding protein. We provide evidence for an in vivo multiprotein complex composed of Pontin52, β-catenin, and lymphocyte enhancer factor-1/T-cell factor. Our results suggest involvement of Pontin52 in the nuclear function of β-catenin.

Bibliography

Bauer, A., Huber, O., & Kemler, R. (1998). Pontin52, an interaction partner of Î²-catenin, binds to the TATA box binding protein. Proceedings of the National Academy of Sciences, 95(25), 14787â14792.

Authors 3

Andreas Bauer (first)
Otmar Huber (additional)
Rolf Kemler (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:40 a.m.)
Deposited	3 years, 2 months ago (June 6, 2022, 10:47 p.m.)
Indexed	2 months ago (July 2, 2025, 2:31 p.m.)
Issued	26 years, 8 months ago (Dec. 8, 1998)
Published	26 years, 8 months ago (Dec. 8, 1998)
Published Online	26 years, 8 months ago (Dec. 8, 1998)
Published Print	26 years, 8 months ago (Dec. 8, 1998)

Funders 0

None

BibTeX

@article{Bauer_1998, title={Pontin52, an interaction partner of β-catenin, binds to the TATA box binding protein}, volume={95}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.95.25.14787}, DOI={10.1073/pnas.95.25.14787}, number={25}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Bauer, Andreas and Huber, Otmar and Kemler, Rolf}, year={1998}, month=dec, pages={14787–14792} }

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