DOI: 10.1073/pnas.95.21.12364. Isolation and characterization of mammalian homologs of the <i>Drosophila</i> gene <i>glial cells missing</i>

Isolation and characterization of mammalian homologs of the Drosophila gene glial cells missing

10.1073/pnas.95.21.12364

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The glial cells missing ( gcm ) gene in Drosophila encodes a transcription factor that determines the choice between glial and neuronal fates. We report here the isolation of two mammalian gcm homologs, Gcm1 and Gcm2 , and the characterization of their expression patterns during embryonic development. Although Gcm2 is expressed in neural tissues at a low level, the major sites of expression for both of the mammalian genes are nonneural, suggesting that the functions of the mammalian homologs have diverged and diversified. However, when expressed ectopically, Gcm1 can substitute functionally for Drosophila gcm by transforming presumptive neurons into glia. Thus, certain biochemical properties, although not the specificity of the tissue in which the gene is expressed, have been conserved through the evolution of the Gcm gene family.

Bibliography

Kim, J., Jones, B. W., Zock, C., Chen, Z., Wang, H., Goodman, C. S., & Anderson, D. J. (1998). Isolation and characterization of mammalian homologs of the Drosophila gene glial cells missing. Proceedings of the National Academy of Sciences, 95(21), 12364â12369.

Authors 7

Jaesang Kim (first)
Bradley W. Jones (additional)
Christiane Zock (additional)
Zhoufeng Chen (additional)
Hai Wang (additional)
Corey S. Goodman (additional)
David J. Anderson (additional)

References 26 Referenced 168

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:40 a.m.)
Deposited	3 years, 2 months ago (June 6, 2022, 10:54 p.m.)
Indexed	1 month ago (Aug. 3, 2025, 12:37 a.m.)
Issued	26 years, 10 months ago (Oct. 13, 1998)
Published	26 years, 10 months ago (Oct. 13, 1998)
Published Online	26 years, 10 months ago (Oct. 13, 1998)
Published Print	26 years, 10 months ago (Oct. 13, 1998)

Funders 0

None

BibTeX

@article{Kim_1998, title={Isolation and characterization of mammalian homologs of the Drosophila gene glial cells missing}, volume={95}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.95.21.12364}, DOI={10.1073/pnas.95.21.12364}, number={21}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Kim, Jaesang and Jones, Bradley W. and Zock, Christiane and Chen, Zhoufeng and Wang, Hai and Goodman, Corey S. and Anderson, David J.}, year={1998}, month=oct, pages={12364–12369} }

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