DOI: 10.1073/pnas.95.2.681. Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis

Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis

10.1073/pnas.95.2.681

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Nonsteroidal antiinflammatory drugs (NSAIDs) can inhibit colorectal tumorigenesis and are among the few agents known to be useful for the chemoprevention of neoplasia. Here, we show that the tumor suppressive effects of NSAIDs are not likely to be related to a reduction in prostaglandins but rather are due to the elevation of the prostaglandin precursor arachidonic acid (AA). NSAID treatment of colon tumor cells results in a dramatic increase in AA that in turn stimulates the conversion of sphingomyelin to ceramide, a known mediator of apoptosis. These results have significant implications for understanding and improving colon cancer chemoprevention.

Bibliography

Chan, T. A., Morin, P. J., Vogelstein, B., & Kinzler, K. W. (1998). Mechanisms underlying nonsteroidal antiinflammatory drug-mediatedâapoptosis. Proceedings of the National Academy of Sciences, 95(2), 681â686.

Authors 4

Timothy A. Chan (first)
Patrice J. Morin (additional)
Bert Vogelstein (additional)
Kenneth W. Kinzler (additional)

References 43 Referenced 450

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:40 a.m.)
Deposited	2 years, 4 months ago (April 22, 2023, 8:26 a.m.)
Indexed	1 week, 3 days ago (Aug. 26, 2025, 2:24 a.m.)
Issued	27 years, 7 months ago (Jan. 20, 1998)
Published	27 years, 7 months ago (Jan. 20, 1998)
Published Online	27 years, 7 months ago (Jan. 20, 1998)
Published Print	27 years, 7 months ago (Jan. 20, 1998)

Funders 0

None

BibTeX

@article{Chan_1998, title={Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis}, volume={95}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.95.2.681}, DOI={10.1073/pnas.95.2.681}, number={2}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Chan, Timothy A. and Morin, Patrice J. and Vogelstein, Bert and Kinzler, Kenneth W.}, year={1998}, month=jan, pages={681–686} }

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