DOI: 10.1073/pnas.95.19.11246. Very late DNA replication in the human cell cycle

Very late DNA replication in the human cell cycle

10.1073/pnas.95.19.11246

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

G 2 was defined originally as the temporal gap between the termination of DNA replication and the beginning of mitosis. In human cells, the G 2 period was estimated to be 3–4 h. However, the absence of replicative DNA synthesis during this period designated G 2 has never been shown conclusively. In this report, we show that, at some autosomal and X linked loci, programmed DNA replication continues within 90 min of mitosis. Furthermore, the major accumulation of cyclin B1, a cell-cycle marker that is usually ascribed to G 2 , overlaps extensively with very late DNA replication. We conclude that the G 2 period is much shorter than previously thought and may, in some cells, be nonexistent.

Bibliography

Widrow, R. J., Hansen, R. S., Kawame, H., Gartler, S. M., & Laird, C. D. (1998). Very late DNA replication in the human cell cycle. Proceedings of the National Academy of Sciences, 95(19), 11246â11250.

Authors 5

R. J. Widrow (first)
R. Scott Hansen (additional)
Hiroshi Kawame (additional)
Stanley M. Gartler (additional)
Charles D. Laird (additional)

References 28 Referenced 35

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B Alberts, D Bray, J Lewis, M Raff, K Roberts, J D Watson Molecular Biology of the Cell (Garland, New York), pp. 865 (1994). / Molecular Biology of the Cell by Alberts B (1994)
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10.1126/science.6719109

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:40 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 3:57 p.m.)
Indexed	1 month, 2 weeks ago (July 12, 2025, 6:59 p.m.)
Issued	26 years, 11 months ago (Sept. 15, 1998)
Published	26 years, 11 months ago (Sept. 15, 1998)
Published Online	26 years, 11 months ago (Sept. 15, 1998)
Published Print	26 years, 11 months ago (Sept. 15, 1998)

Funders 0

None

BibTeX

@article{Widrow_1998, title={Very late DNA replication in the human cell cycle}, volume={95}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.95.19.11246}, DOI={10.1073/pnas.95.19.11246}, number={19}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Widrow, R. J. and Hansen, R. Scott and Kawame, Hiroshi and Gartler, Stanley M. and Laird, Charles D.}, year={1998}, month=sep, pages={11246–11250} }

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