DOI: 10.1073/pnas.95.18.10413. A novel DNA-binding motif in MarA: The first structure for an AraC family transcriptional activator

A novel DNA-binding motif in MarA: The first structure for an AraC family transcriptional activator

10.1073/pnas.95.18.10413

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

A crystal structure for a member of the AraC prokaryotic transcriptional activator family, MarA, in complex with its cognate DNA-binding site is described. MarA consists of two similar subdomains, each containing a helix–turn–helix DNA-binding motif. The two recognition helices of the motifs are inserted into adjacent major groove segments on the same face of the DNA but are separated by only 27 Å thereby bending the DNA by ≈35°. Extensive interactions between the recognition helices and the DNA major groove provide the sequence specificity.

Bibliography

Rhee, S., Martin, R. G., Rosner, J. L., & Davies, D. R. (1998). A novel DNA-binding motif in MarA: The first structure for an AraC family transcriptional activator. Proceedings of the National Academy of Sciences, 95(18), 10413â10418.

Authors 4

Sangkee Rhee (first)
Robert G. Martin (additional)
Judah L. Rosner (additional)
David R. Davies (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:40 a.m.)
Deposited	3 years, 2 months ago (June 6, 2022, 9:32 p.m.)
Indexed	3 months, 2 weeks ago (May 14, 2025, 1:24 a.m.)
Issued	27 years ago (Sept. 1, 1998)
Published	27 years ago (Sept. 1, 1998)
Published Online	27 years ago (Sept. 1, 1998)
Published Print	27 years ago (Sept. 1, 1998)

Funders 0

None

BibTeX

@article{Rhee_1998, title={A novel DNA-binding motif in MarA: The first structure for an AraC family transcriptional activator}, volume={95}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.95.18.10413}, DOI={10.1073/pnas.95.18.10413}, number={18}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Rhee, Sangkee and Martin, Robert G. and Rosner, Judah L. and Davies, David R.}, year={1998}, month=sep, pages={10413–10418} }

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