DOI: 10.1073/pnas.95.16.9448. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

10.1073/pnas.95.16.9448

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The chemokine stromal cell-derived factor 1, SDF-1, is an important regulator of leukocyte and hematopoietic precursor migration and pre-B cell proliferation. The receptor for SDF-1, CXCR4, also functions as a coreceptor for T-tropic HIV-1 entry. We find that mice deficient for CXCR4 die perinatally and display profound defects in the hematopoietic and nervous systems. CXCR4-deficient mice have severely reduced B-lymphopoiesis, reduced myelopoiesis in fetal liver, and a virtual absence of myelopoiesis in bone marrow. However, T-lymphopoiesis is unaffected. Furthermore, the cerebellum develops abnormally with an irregular external granule cell layer, ectopically located Purkinje cells, and numerous chromophilic cell clumps of abnormally migrated granule cells within the cerebellar anlage. Identical defects are observed in mice lacking SDF-1, suggesting a monogamous relationship between CXCR4 and SDF-1. This receptor-ligand selectivity is unusual among chemokines and their receptors, as is the function in migration of nonhematopoietic cells.

Bibliography

Ma, Q., Jones, D., Borghesani, P. R., Segal, R. A., Nagasawa, T., Kishimoto, T., Bronson, R. T., & Springer, T. A. (1998). Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proceedings of the National Academy of Sciences, 95(16), 9448â9453.

Authors 8

Qing Ma (first)
Dan Jones (additional)
Paul R. Borghesani (additional)
Rosalind A. Segal (additional)
Takashi Nagasawa (additional)
Tadamitsu Kishimoto (additional)
Roderick T. Bronson (additional)
Timothy A. Springer (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:39 a.m.)
Deposited	2 years, 4 months ago (April 22, 2023, 8:25 a.m.)
Indexed	1 month ago (July 26, 2025, 4:49 a.m.)
Issued	27 years ago (Aug. 4, 1998)
Published	27 years ago (Aug. 4, 1998)
Published Online	27 years ago (Aug. 4, 1998)
Published Print	27 years ago (Aug. 4, 1998)

Funders 0

None

BibTeX

@article{Ma_1998, title={Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice}, volume={95}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.95.16.9448}, DOI={10.1073/pnas.95.16.9448}, number={16}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Ma, Qing and Jones, Dan and Borghesani, Paul R. and Segal, Rosalind A. and Nagasawa, Takashi and Kishimoto, Tadamitsu and Bronson, Roderick T. and Springer, Timothy A.}, year={1998}, month=aug, pages={9448–9453} }

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  "container-title-short": "Proc. Natl. Acad. Sci. U.S.A.",
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