Crossref
journal-article
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences (341)
Abstract
The three-dimensional structure of the human Rap30 DNA-binding domain has been solved by multinuclear NMR spectroscopy. The structure of the globular domain is strikingly similar to that of linker histone H5 and its fold places Rap30 into the “winged” helix–turn–helix family of eukaryotic transcription factors. Although the domain interacts weakly with DNA, the binding surface was identified and shown to be consistent with the structure of the HNF-3/ fork head –DNA complex. The architecture of the Rap30 DNA-binding domain has important implications for the function of Rap30 in the assembly of the preinitiation complex. In analogy to the function of linker histones in chromatin formation, the fold of the Rap30 DNA-binding domain suggests that its role in transcription initiation may be that of a condensation factor for preinitiation complex assembly. Functional similarity to linker histones may explain the dependence of Rap30 binding on the bent DNA environment induced by the TATA box-binding protein. Cryptic sequence identity and functional homology between the Rap30 DNA-binding domain and region 4 of Escherichia coli σ 70 may indicate that the σ factors also possess a linker histone-like activity in the formation of a prokaryotic closed complex.
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Dates
| Type | When |
|---|---|
| Created | 23 years ago (July 26, 2002, 10:40 a.m.) |
| Deposited | 3 years, 2 months ago (June 6, 2022, 9:31 p.m.) |
| Indexed | 1 year, 1 month ago (July 1, 2024, 1:12 p.m.) |
| Issued | 27 years ago (Aug. 4, 1998) |
| Published | 27 years ago (Aug. 4, 1998) |
| Published Online | 27 years ago (Aug. 4, 1998) |
| Published Print | 27 years ago (Aug. 4, 1998) |
@article{Groft_1998, title={Structural homology between the Rap30 DNA-binding domain and linker histone H5: Implications for preinitiation complex assembly}, volume={95}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.95.16.9117}, DOI={10.1073/pnas.95.16.9117}, number={16}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Groft, Caroline M. and Uljon, Sacha N. and Wang, Rong and Werner, Milton H.}, year={1998}, month=aug, pages={9117–9122} }