Positional cloning of ZNF 217 and NABC 1 : Genes amplified at 20q13.2 and overexpressed in breast carcinoma
10.1073/pnas.95.15.8703
Crossref journal-article
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences (341)
Abstract

We report here the molecular cloning of an ≈1-Mb region of recurrent amplification at 20q13.2 in breast cancer and other tumors and the delineation of a 260-kb common region of amplification. Analysis of the 1-Mb region produced evidence for five genes, ZNF217 , ZNF218 , and NABC1 , PIC1L ( PIC1-l ike), CYP24 , and a pseudogene CRP ( C yclophillin R elated P seudogene). ZNF217 and NABC1 emerged as strong candidate oncogenes and were characterized in detail. NABC1 is predicted to encode a 585-aa protein of unknown function and is overexpressed in most but not all breast cancer cell lines in which it was amplified. ZNF217 is centrally located in the 260-kb common region of amplification, transcribed in multiple normal tissues, and overexpressed in all cell lines and tumors in which it is amplified and in two in which it is not. ZNF217 is predicted to encode alternately spliced, Kruppel-like transcription factors of 1,062 and 1,108 aa, each having a DNA-binding domain (eight C2H2 zinc fingers) and a proline-rich transcription activation domain.

Bibliography

Collins, C., Rommens, J. M., Kowbel, D., Godfrey, T., Tanner, M., Hwang, S., Polikoff, D., Nonet, G., Cochran, J., Myambo, K., Jay, K. E., Froula, J., Cloutier, T., Kuo, W.-L., Yaswen, P., Dairkee, S., Giovanola, J., Hutchinson, G. B., Isola, J., … Gray, J. W. (1998). Positional cloning of ZNF 217 and NABC 1  : Genes amplified at 20q13.2 and overexpressed in breast carcinoma. Proceedings of the National Academy of Sciences, 95(15), 8703–8708.

Authors 27
  1. Colin Collins (first)
  2. Johanna M. Rommens (additional)
  3. David Kowbel (additional)
  4. Tony Godfrey (additional)
  5. Minna Tanner (additional)
  6. Soo-in Hwang (additional)
  7. Daniel Polikoff (additional)
  8. Genevieve Nonet (additional)
  9. Joanne Cochran (additional)
  10. Ken Myambo (additional)
  11. Karen E. Jay (additional)
  12. Jeff Froula (additional)
  13. Thomas Cloutier (additional)
  14. Wen-Lin Kuo (additional)
  15. Paul Yaswen (additional)
  16. Shanaz Dairkee (additional)
  17. Jennifer Giovanola (additional)
  18. Gordon B. Hutchinson (additional)
  19. Jorma Isola (additional)
  20. Olli-P Kallioniemi (additional)
  21. Mike Palazzolo (additional)
  22. Chris Martin (additional)
  23. Cheryl Ericsson (additional)
  24. Dan Pinkel (additional)
  25. Donna Albertson (additional)
  26. Wu-Bo Li (additional)
  27. Joe W. Gray (additional)
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Dates
Type When
Created 23 years ago (July 26, 2002, 10:32 a.m.)
Deposited 3 years, 2 months ago (June 6, 2022, 9:36 p.m.)
Indexed 1 month, 3 weeks ago (July 1, 2025, 9:48 a.m.)
Issued 27 years, 1 month ago (July 21, 1998)
Published 27 years, 1 month ago (July 21, 1998)
Published Online 27 years, 1 month ago (July 21, 1998)
Published Print 27 years, 1 month ago (July 21, 1998)
Funders 0

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@article{Collins_1998, title={Positional cloning of ZNF 217 and NABC 1  : Genes amplified at 20q13.2 and overexpressed in breast carcinoma}, volume={95}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.95.15.8703}, DOI={10.1073/pnas.95.15.8703}, number={15}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Collins, Colin and Rommens, Johanna M. and Kowbel, David and Godfrey, Tony and Tanner, Minna and Hwang, Soo-in and Polikoff, Daniel and Nonet, Genevieve and Cochran, Joanne and Myambo, Ken and Jay, Karen E. and Froula, Jeff and Cloutier, Thomas and Kuo, Wen-Lin and Yaswen, Paul and Dairkee, Shanaz and Giovanola, Jennifer and Hutchinson, Gordon B. and Isola, Jorma and Kallioniemi, Olli-P and Palazzolo, Mike and Martin, Chris and Ericsson, Cheryl and Pinkel, Dan and Albertson, Donna and Li, Wu-Bo and Gray, Joe W.}, year={1998}, month=jul, pages={8703–8708} }