DOI: 10.1073/pnas.95.15.8538. Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways

Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways

10.1073/pnas.95.15.8538

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

A multiprotein complex isolated from murine cells is identified as a counterpart of the yeast Mediator of transcriptional regulation on the basis of the following: homologs of two subunits of yeast Mediator, Srb7 and Med7, copurify with the complex; peptide sequencing reveals, in addition, homologs of the yeast Mediator subunits Rgr1 and Med6; as with yeast Mediator, the mouse complex binds to the RNA polymerase II C-terminal domain (CTD) and stimulates phosphorylation of the CTD by TFIIH. Peptide sequencing also identifies a component of mouse Mediator as a relative of Ring-3 protein, a mitogen-activated nuclear protein kinase, raising the possibility of Mediator as an end point of signal transduction pathways.

Bibliography

Jiang, Y. W., Veschambre, P., Erdjument-Bromage, H., Tempst, P., Conaway, J. W., Conaway, R. C., & Kornberg, R. D. (1998). Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways. Proceedings of the National Academy of Sciences, 95(15), 8538â8543.

Authors 7

Yi Wei Jiang (first)
Philippe Veschambre (additional)
Hediye Erdjument-Bromage (additional)
Paul Tempst (additional)
Joan W. Conaway (additional)
Ronald C. Conaway (additional)
Roger D. Kornberg (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:32 a.m.)
Deposited	2 years, 4 months ago (April 22, 2023, 8:10 a.m.)
Indexed	3 weeks, 1 day ago (Aug. 5, 2025, 9:07 a.m.)
Issued	27 years, 1 month ago (July 21, 1998)
Published	27 years, 1 month ago (July 21, 1998)
Published Online	27 years, 1 month ago (July 21, 1998)
Published Print	27 years, 1 month ago (July 21, 1998)

Funders 0

None

BibTeX

@article{Jiang_1998, title={Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways}, volume={95}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.95.15.8538}, DOI={10.1073/pnas.95.15.8538}, number={15}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Jiang, Yi Wei and Veschambre, Philippe and Erdjument-Bromage, Hediye and Tempst, Paul and Conaway, Joan W. and Conaway, Ronald C. and Kornberg, Roger D.}, year={1998}, month=jul, pages={8538–8543} }

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