DOI: 10.1073/pnas.95.15.8428. The elusive function of metallothioneins

The elusive function of metallothioneins

10.1073/pnas.95.15.8428

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Biochemistry and genetics are both required to elucidate the function of macromolecules. There is no question that metallothioneins (MTs) have unique biochemical properties, but genetic experiments have not substantiated the importance of MTs under physiological conditions. Even after thousands of studies describing the structure, biochemical characteristics, tissue distribution, induction, and consequences of genetic disruption and deliberate overexpression, the evolutionary forces that led to the initial appearance, gene duplications, and nearly ubiquitous expression of MTs remain enigmatic.

Bibliography

Palmiter, R. D. (1998). The elusive function of metallothioneins. Proceedings of the National Academy of Sciences, 95(15), 8428â8430.

Authors 1

Richard D. Palmiter (first)

References 55 Referenced 557

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D R Winge, C T Dameron Metallothionein III, eds K Y Suzuki, N Imura, M Kimura (Birkhäuser, Basel), pp. 381–397 (1993). / Metallothionein III by Winge D R (1993)
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E J Kelly, C J Quaife, G J Froelick, R D Palmiter J Nutr 126, 1782–1790 (1996). / J Nutr by Kelly E J (1996)
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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:39 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 4:35 p.m.)
Indexed	21 hours, 29 minutes ago (Aug. 29, 2025, 5:58 a.m.)
Issued	27 years, 1 month ago (July 21, 1998)
Published	27 years, 1 month ago (July 21, 1998)
Published Online	27 years, 1 month ago (July 21, 1998)
Published Print	27 years, 1 month ago (July 21, 1998)

Funders 0

None

BibTeX

@article{Palmiter_1998, title={The elusive function of metallothioneins}, volume={95}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.95.15.8428}, DOI={10.1073/pnas.95.15.8428}, number={15}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Palmiter, Richard D.}, year={1998}, month=jul, pages={8428–8430} }

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